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Dietary antioxidants and risk of Parkinson's disease in two population-based cohorts.
Mov Disord. 2017 Nov; 32(11):1631-1636.MD

Abstract

BACKGROUND

A neuroprotective effect of dietary antioxidants on Parkinson's disease (PD) risk has been suggested, but epidemiological evidence is limited.

OBJECTIVES

To examine the associations between intake of dietary antioxidant vitamins and total antioxidant capacity and risk of PD.

METHODS

We prospectively assessed the relationships of dietary antioxidant vitamins C and E, β-carotene, and total antioxidant capacity with PD risk in two population-based cohorts (38,937 women and 45,837 men).

RESULTS

During a mean 14.9-year follow-up period, 1,329 PD cases were identified. Dietary intake of β-carotene was associated with a lower risk of PD (hazard ratio: 0.86; 95% confidence interval: 0.78-0.95; Ptrend < 0.01 for women and hazard ratio: 0.91; 95% confidence interval: 0.84-0.99; Ptrend = 0.05 for men). An inverse association between dietary vitamin E and PD risk was found in women (hazard ratio: 0.87; 95% confidence interval: 0.79-0.96; Ptrend = 0.02). Dietary intake of vitamin C was inversely associated with PD risk in women at borderline significance (hazard ratio: 0.91; 95% confidence interval: 0.83-1.00; Ptrend = 0.04). There was no association between dietary total antioxidant capacity and PD risk in either women (hazard ratio: 0.93; 95% confidence interval: 0.84-1.02; Ptrend = 0.35) or men (hazard ratio: 1.00; 95% confidence interval: 0.93-1.07; Ptrend = 0.97).

CONCLUSION

Intake of dietary vitamin E and β-carotene was associated with a lower risk of PD. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Links

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Authors+Show Affiliations

Yang F
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Wolk A
Institute of Environmental Medicine, Unit of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden.
Håkansson N
Institute of Environmental Medicine, Unit of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden.
Pedersen NL
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Department of Psychology, University of Southern California, Los Angeles, California, USA.
Wirdefeldt K
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

MeSH

AgedAntioxidantsAscorbic AcidDietFemaleFollow-Up StudiesHumansMaleMiddle AgedNeuroprotective AgentsParkinson DiseaseSex FactorsSwedenVitamin Ebeta Carotene

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28881039

Citation

Yang, Fei, et al. "Dietary Antioxidants and Risk of Parkinson's Disease in Two Population-based Cohorts." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 32, no. 11, 2017, pp. 1631-1636.
Yang F, Wolk A, Håkansson N, et al. Dietary antioxidants and risk of Parkinson's disease in two population-based cohorts. Mov Disord. 2017;32(11):1631-1636.
Yang, F., Wolk, A., Håkansson, N., Pedersen, N. L., & Wirdefeldt, K. (2017). Dietary antioxidants and risk of Parkinson's disease in two population-based cohorts. Movement Disorders : Official Journal of the Movement Disorder Society, 32(11), 1631-1636. https://doi.org/10.1002/mds.27120
Yang F, et al. Dietary Antioxidants and Risk of Parkinson's Disease in Two Population-based Cohorts. Mov Disord. 2017;32(11):1631-1636. PubMed PMID: 28881039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary antioxidants and risk of Parkinson's disease in two population-based cohorts. AU - Yang,Fei, AU - Wolk,Alicja, AU - Håkansson,Niclas, AU - Pedersen,Nancy L, AU - Wirdefeldt,Karin, Y1 - 2017/09/07/ PY - 2017/01/23/received PY - 2017/06/29/revised PY - 2017/07/03/accepted PY - 2017/9/8/pubmed PY - 2018/6/26/medline PY - 2017/9/8/entrez KW - Parkinson's disease KW - antioxidants KW - diet KW - risk factors SP - 1631 EP - 1636 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 32 IS - 11 N2 - BACKGROUND: A neuroprotective effect of dietary antioxidants on Parkinson's disease (PD) risk has been suggested, but epidemiological evidence is limited. OBJECTIVES: To examine the associations between intake of dietary antioxidant vitamins and total antioxidant capacity and risk of PD. METHODS: We prospectively assessed the relationships of dietary antioxidant vitamins C and E, β-carotene, and total antioxidant capacity with PD risk in two population-based cohorts (38,937 women and 45,837 men). RESULTS: During a mean 14.9-year follow-up period, 1,329 PD cases were identified. Dietary intake of β-carotene was associated with a lower risk of PD (hazard ratio: 0.86; 95% confidence interval: 0.78-0.95; Ptrend < 0.01 for women and hazard ratio: 0.91; 95% confidence interval: 0.84-0.99; Ptrend = 0.05 for men). An inverse association between dietary vitamin E and PD risk was found in women (hazard ratio: 0.87; 95% confidence interval: 0.79-0.96; Ptrend = 0.02). Dietary intake of vitamin C was inversely associated with PD risk in women at borderline significance (hazard ratio: 0.91; 95% confidence interval: 0.83-1.00; Ptrend = 0.04). There was no association between dietary total antioxidant capacity and PD risk in either women (hazard ratio: 0.93; 95% confidence interval: 0.84-1.02; Ptrend = 0.35) or men (hazard ratio: 1.00; 95% confidence interval: 0.93-1.07; Ptrend = 0.97). CONCLUSION: Intake of dietary vitamin E and β-carotene was associated with a lower risk of PD. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/28881039/Dietary_antioxidants_and_risk_of_Parkinson's_disease_in_two_population_based_cohorts_ L2 - https://doi.org/10.1002/mds.27120 DB - PRIME DP - Unbound Medicine ER -