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Vascular density of superficial esophageal squamous cell carcinoma determined by direct observation of resected specimen using narrow band imaging with magnifying endoscopy.
Dis Esophagus 2017; 30(11):1-5DE

Abstract

Observation of the microvasculature using narrow band imaging (NBI) with magnifying endoscopy is useful for diagnosing superficial squamous cell carcinoma. Increased vascular density is indicative of cancer, but not many studies have reported differences between cancerous and noncancerous areas based on an objective comparison. We observed specimens of endoscopic submucosal dissection (ESD) using NBI magnification, and determined the vascular density of cancerous and noncancerous areas. A total of 25 lesions of esophageal squamous cell carcinoma that were dissected en bloc by ESD between July 2013 and December 2013 were subjected to NBI magnification. We constructed a device that holds an endoscope and precisely controls the movement along the vertical axis in order to observe submerged specimens by NBI magnification. NBI image files of both cancerous (pathologically determined invasion depth, m1/2) and surrounding noncancerous areas were created and subjected to vascular density assessment by two endoscopists who were blinded to clinical information. The invasion depth was m1/2 in 20, m3/sm1 in four and sm2 in one esophageal cancer lesion. Mean vascular density was significantly increased in cancerous areas (37.6 ± 16.3 vessels/mm2) compared with noncancerous areas (17.6 ± 10.0 vessels/mm2) (P < 0.05). The correlation coefficients between vascular density determined by two endoscopists were 0.86 and 0.81 in cancerous and noncancerous areas, respectively. Receiver operating curve (ROC) analysis revealed that the area under the curve (AUC) of vascular density was 0.895 (95% CI, 0.804-0.986). For this ROC curve, sensitivity was 78.3% and specificity was 87.0% when the cutoff value of vascular density was 26 vessels/mm2. NBI magnification confirmed significant increases in vascular density in cancerous areas compared with noncancerous areas in esophageal squamous cell carcinoma. The rates of agreement between vascular density values determined by two independent operators were high.

Authors+Show Affiliations

Departments of Gastroenterology.Departments of Gastroenterology.Departments of Gastroenterology.Departments of Gastroenterology.Departments of Gastroenterology.Departments of Gastroenterology.Departments of Gastroenterology.Departments of Gastroenterology.Departments of Gastroenterology.Departments of Gastroenterology.Departments of Gastroenterology.Pathology, Toranomon Hospital, Minato-ku, Tokyo, Japan.Departments of Gastroenterology.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

28881911

Citation

Kikuchi, D, et al. "Vascular Density of Superficial Esophageal Squamous Cell Carcinoma Determined By Direct Observation of Resected Specimen Using Narrow Band Imaging With Magnifying Endoscopy." Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus, vol. 30, no. 11, 2017, pp. 1-5.
Kikuchi D, Iizuka T, Hoteya S, et al. Vascular density of superficial esophageal squamous cell carcinoma determined by direct observation of resected specimen using narrow band imaging with magnifying endoscopy. Dis Esophagus. 2017;30(11):1-5.
Kikuchi, D., Iizuka, T., Hoteya, S., Nomura, K., Kuribayashi, Y., Toba, T., ... Kaise, M. (2017). Vascular density of superficial esophageal squamous cell carcinoma determined by direct observation of resected specimen using narrow band imaging with magnifying endoscopy. Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus, 30(11), pp. 1-5. doi:10.1093/dote/dox105.
Kikuchi D, et al. Vascular Density of Superficial Esophageal Squamous Cell Carcinoma Determined By Direct Observation of Resected Specimen Using Narrow Band Imaging With Magnifying Endoscopy. Dis Esophagus. 2017 Nov 1;30(11):1-5. PubMed PMID: 28881911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular density of superficial esophageal squamous cell carcinoma determined by direct observation of resected specimen using narrow band imaging with magnifying endoscopy. AU - Kikuchi,D, AU - Iizuka,T, AU - Hoteya,S, AU - Nomura,K, AU - Kuribayashi,Y, AU - Toba,T, AU - Tanaka,M, AU - Yamashita,S, AU - Furuhata,T, AU - Matsui,A, AU - Mitani,T, AU - Inoshita,N, AU - Kaise,M, PY - 2017/03/19/received PY - 2017/07/26/accepted PY - 2017/9/9/entrez PY - 2017/9/9/pubmed PY - 2018/5/25/medline KW - endoscopy KW - esophageal cancers KW - magnifying endoscopy KW - narrow band imaging KW - squamous cell carcinoma SP - 1 EP - 5 JF - Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus JO - Dis. Esophagus VL - 30 IS - 11 N2 - Observation of the microvasculature using narrow band imaging (NBI) with magnifying endoscopy is useful for diagnosing superficial squamous cell carcinoma. Increased vascular density is indicative of cancer, but not many studies have reported differences between cancerous and noncancerous areas based on an objective comparison. We observed specimens of endoscopic submucosal dissection (ESD) using NBI magnification, and determined the vascular density of cancerous and noncancerous areas. A total of 25 lesions of esophageal squamous cell carcinoma that were dissected en bloc by ESD between July 2013 and December 2013 were subjected to NBI magnification. We constructed a device that holds an endoscope and precisely controls the movement along the vertical axis in order to observe submerged specimens by NBI magnification. NBI image files of both cancerous (pathologically determined invasion depth, m1/2) and surrounding noncancerous areas were created and subjected to vascular density assessment by two endoscopists who were blinded to clinical information. The invasion depth was m1/2 in 20, m3/sm1 in four and sm2 in one esophageal cancer lesion. Mean vascular density was significantly increased in cancerous areas (37.6 ± 16.3 vessels/mm2) compared with noncancerous areas (17.6 ± 10.0 vessels/mm2) (P < 0.05). The correlation coefficients between vascular density determined by two endoscopists were 0.86 and 0.81 in cancerous and noncancerous areas, respectively. Receiver operating curve (ROC) analysis revealed that the area under the curve (AUC) of vascular density was 0.895 (95% CI, 0.804-0.986). For this ROC curve, sensitivity was 78.3% and specificity was 87.0% when the cutoff value of vascular density was 26 vessels/mm2. NBI magnification confirmed significant increases in vascular density in cancerous areas compared with noncancerous areas in esophageal squamous cell carcinoma. The rates of agreement between vascular density values determined by two independent operators were high. SN - 1442-2050 UR - https://www.unboundmedicine.com/medline/citation/28881911/Vascular_density_of_superficial_esophageal_squamous_cell_carcinoma_determined_by_direct_observation_of_resected_specimen_using_narrow_band_imaging_with_magnifying_endoscopy_ L2 - https://academic.oup.com/dote/article-lookup/doi/10.1093/dote/dox105 DB - PRIME DP - Unbound Medicine ER -