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Sarcopenia Predicts Prognosis in Patients with Newly Diagnosed Hepatocellular Carcinoma, Independent of Tumor Stage and Liver Function.
Cancer Res Treat 2018; 50(3):843-851CR

Abstract

Purpose

The purpose of this study was to demonstrate the prognostic significance of changes in body composition in patients with newly diagnosed hepatocellular carcinoma (HCC).

Materials and Methods

Patients (n=178) newly diagnosed with HCC participated in the study between 2007 and 2012. Areas of skeletal muscle and abdominal fat were directly measured using a three-dimensional workstation. Cox proportional-hazards modes were used to estimate the effect of baseline variables on overall survival. The inverse probability of treatmentweighting (IPTW) method was used to minimize confounding bias.

Results

Cutoff values for sarcopenia, obtained from receiver-operating characteristic curves, were defined as skeletal muscle index at the third lumbar vertebra of ≤ 45.8 cm/m2 for males and ≤ 43.0 cm/m2 for females. Sarcopenia patients were older, more likely to be female, and had lower body mass index. Univariable analysis showed that the presence of sarcopenia and visceral to subcutaneous fat area ratio (VSR) were significantly associatedwith prognosis. The multivariable analyses revealed that VSR was predictive of overall survival. However, in the multivariable Cox model adjusted by IPTW, sarcopenia, not VSR, were associated with overall survival.

Conclusion

The presence of sarcopenia at HCC diagnosis is independently associated with survival.

Authors+Show Affiliations

Department of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.Department of Radiology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.Department of Applied Statistics, Gachon University, Seongnam, Korea.Department of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.Department of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.Department of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.Department of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.Department of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.Department of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.Department of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28882021

Citation

Ha, Yeonjung, et al. "Sarcopenia Predicts Prognosis in Patients With Newly Diagnosed Hepatocellular Carcinoma, Independent of Tumor Stage and Liver Function." Cancer Research and Treatment : Official Journal of Korean Cancer Association, vol. 50, no. 3, 2018, pp. 843-851.
Ha Y, Kim D, Han S, et al. Sarcopenia Predicts Prognosis in Patients with Newly Diagnosed Hepatocellular Carcinoma, Independent of Tumor Stage and Liver Function. Cancer Res Treat. 2018;50(3):843-851.
Ha, Y., Kim, D., Han, S., Chon, Y. E., Lee, Y. B., Kim, M. N., ... Hwang, S. G. (2018). Sarcopenia Predicts Prognosis in Patients with Newly Diagnosed Hepatocellular Carcinoma, Independent of Tumor Stage and Liver Function. Cancer Research and Treatment : Official Journal of Korean Cancer Association, 50(3), pp. 843-851. doi:10.4143/crt.2017.232.
Ha Y, et al. Sarcopenia Predicts Prognosis in Patients With Newly Diagnosed Hepatocellular Carcinoma, Independent of Tumor Stage and Liver Function. Cancer Res Treat. 2018;50(3):843-851. PubMed PMID: 28882021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sarcopenia Predicts Prognosis in Patients with Newly Diagnosed Hepatocellular Carcinoma, Independent of Tumor Stage and Liver Function. AU - Ha,Yeonjung, AU - Kim,Daejung, AU - Han,Seungbong, AU - Chon,Young Eun, AU - Lee,Yun Bin, AU - Kim,Mi Na, AU - Lee,Joo Ho, AU - Park,Hana, AU - Rim,Kyu Sung, AU - Hwang,Seong Gyu, Y1 - 2017/09/04/ PY - 2017/05/16/received PY - 2017/08/24/accepted PY - 2017/9/9/pubmed PY - 2018/10/26/medline PY - 2017/9/9/entrez KW - Overall survival KW - Prognosis KW - Sarcopenia KW - Visceral fat KW - Hepatocellular carcinoma SP - 843 EP - 851 JF - Cancer research and treatment : official journal of Korean Cancer Association JO - Cancer Res Treat VL - 50 IS - 3 N2 - Purpose: The purpose of this study was to demonstrate the prognostic significance of changes in body composition in patients with newly diagnosed hepatocellular carcinoma (HCC). Materials and Methods: Patients (n=178) newly diagnosed with HCC participated in the study between 2007 and 2012. Areas of skeletal muscle and abdominal fat were directly measured using a three-dimensional workstation. Cox proportional-hazards modes were used to estimate the effect of baseline variables on overall survival. The inverse probability of treatmentweighting (IPTW) method was used to minimize confounding bias. Results: Cutoff values for sarcopenia, obtained from receiver-operating characteristic curves, were defined as skeletal muscle index at the third lumbar vertebra of ≤ 45.8 cm/m2 for males and ≤ 43.0 cm/m2 for females. Sarcopenia patients were older, more likely to be female, and had lower body mass index. Univariable analysis showed that the presence of sarcopenia and visceral to subcutaneous fat area ratio (VSR) were significantly associatedwith prognosis. The multivariable analyses revealed that VSR was predictive of overall survival. However, in the multivariable Cox model adjusted by IPTW, sarcopenia, not VSR, were associated with overall survival. Conclusion: The presence of sarcopenia at HCC diagnosis is independently associated with survival. SN - 2005-9256 UR - https://www.unboundmedicine.com/medline/citation/28882021/Sarcopenia_Predicts_Prognosis_in_Patients_with_Newly_Diagnosed_Hepatocellular_Carcinoma_Independent_of_Tumor_Stage_and_Liver_Function_ L2 - https://dx.doi.org/10.4143/crt.2017.232 DB - PRIME DP - Unbound Medicine ER -