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Effect of etoricoxib on experimental oxidative testicular ischemia-reperfusion damage in rats induced with torsion-detorsion.
Korean J Physiol Pharmacol. 2017 Sep; 21(5):457-464.KJ

Abstract

Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular I/R damage induced with torsion-detorsion (TD). The etoricoxib + torsion-detorsion (ETD) groups of animals were given etoricoxib in 50 and 100 mg/kg of body weight (ETD-50 and ETD-100), while the testes torsion-detorsion (TTD) and sham operation rat group (SOG) animals were given single oral doses of distilled water as a solvent. TTD, ETD-50 and ETD-100 groups were subjected to 720° degrees torsion for four hours, and detorsion for four hours. The SOG group was not subjected to this procedure. Biochemical, gene expression and histopathological analyses were carried out on the testicular tissues. The levels of malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) were significantly higher, and the levels of total glutathione (tGSH) and glutathione reductase (GSHRd) were significantly lower in the TTD group, compared to the ETD-50, ETD-100 and SOG groups. Etoricoxib at a dose of 100 mg/kg better prevented I/R damage than the 50 mg/kg dose. Etoricoxib may be useful in clinical practice in the reduction of I/R damage on testes caused by torsion-detorsion.

Authors+Show Affiliations

Department of Urology, Faculty of Medicine, Ataturk University, Erzurum 25240, Turkey.Department of Urology, Bayburt State Hospital, Bayburt 69010, Turkey.Department of Urology, Bilecik State Hospital, Bilecik 11100, Turkey.Department of Pharmacology, Faculty of Medicine, Erzincan University, Erzincan 24100, Turkey.Department of Pathology, Mengucek Gazi Education and Research Hospital, Erzincan 24100, Turkey.Department of Urology, Faculty of Medicine, Erzincan University, Erzincan 24100, Turkey.Department of Pharmacology, Faculty of Medicine, Erzincan University, Erzincan 24100, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28883750

Citation

Yapanoglu, Turgut, et al. "Effect of Etoricoxib On Experimental Oxidative Testicular Ischemia-reperfusion Damage in Rats Induced With Torsion-detorsion." The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, vol. 21, no. 5, 2017, pp. 457-464.
Yapanoglu T, Ozkaya F, Yilmaz AH, et al. Effect of etoricoxib on experimental oxidative testicular ischemia-reperfusion damage in rats induced with torsion-detorsion. Korean J Physiol Pharmacol. 2017;21(5):457-464.
Yapanoglu, T., Ozkaya, F., Yilmaz, A. H., Mammadov, R., Cimen, F. K., Hirik, E., & Altuner, D. (2017). Effect of etoricoxib on experimental oxidative testicular ischemia-reperfusion damage in rats induced with torsion-detorsion. The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 21(5), 457-464. https://doi.org/10.4196/kjpp.2017.21.5.457
Yapanoglu T, et al. Effect of Etoricoxib On Experimental Oxidative Testicular Ischemia-reperfusion Damage in Rats Induced With Torsion-detorsion. Korean J Physiol Pharmacol. 2017;21(5):457-464. PubMed PMID: 28883750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of etoricoxib on experimental oxidative testicular ischemia-reperfusion damage in rats induced with torsion-detorsion. AU - Yapanoglu,Turgut, AU - Ozkaya,Fatih, AU - Yilmaz,Ali Haydar, AU - Mammadov,Renad, AU - Cimen,Ferda Keskin, AU - Hirik,Erkan, AU - Altuner,Durdu, Y1 - 2017/08/22/ PY - 2016/06/16/received PY - 2016/08/30/revised PY - 2016/09/09/accepted PY - 2017/9/9/entrez PY - 2017/9/9/pubmed PY - 2017/9/9/medline KW - Etoricoxib KW - Gene expression KW - Ischemia-reperfusion KW - Torsion-detorsion SP - 457 EP - 464 JF - The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology JO - Korean J Physiol Pharmacol VL - 21 IS - 5 N2 - Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular I/R damage induced with torsion-detorsion (TD). The etoricoxib + torsion-detorsion (ETD) groups of animals were given etoricoxib in 50 and 100 mg/kg of body weight (ETD-50 and ETD-100), while the testes torsion-detorsion (TTD) and sham operation rat group (SOG) animals were given single oral doses of distilled water as a solvent. TTD, ETD-50 and ETD-100 groups were subjected to 720° degrees torsion for four hours, and detorsion for four hours. The SOG group was not subjected to this procedure. Biochemical, gene expression and histopathological analyses were carried out on the testicular tissues. The levels of malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) were significantly higher, and the levels of total glutathione (tGSH) and glutathione reductase (GSHRd) were significantly lower in the TTD group, compared to the ETD-50, ETD-100 and SOG groups. Etoricoxib at a dose of 100 mg/kg better prevented I/R damage than the 50 mg/kg dose. Etoricoxib may be useful in clinical practice in the reduction of I/R damage on testes caused by torsion-detorsion. SN - 1226-4512 UR - https://www.unboundmedicine.com/medline/citation/28883750/Effect_of_etoricoxib_on_experimental_oxidative_testicular_ischemia_reperfusion_damage_in_rats_induced_with_torsion_detorsion_ L2 - http://www.kjpp.net/journal/viewJournal.html?year=2017&vol=21&page=457 DB - PRIME DP - Unbound Medicine ER -
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