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The ethics of creating genetically modified children using genome editing.
Curr Opin Endocrinol Diabetes Obes. 2017 Dec; 24(6):418-423.CO

Abstract

PURPOSE OF REVIEW

To review the recent ethical, legal, and social issues surrounding human reproduction involving germline genome editing.

RECENT FINDINGS

Genome editing techniques, such as CRISPR/Cas9, have facilitated genetic modification in human embryos. The most likely purpose of germline genome editing is the prevention of serious genetic disease in offspring. However, complex issues still remain, including irremediable risks to fetuses and future generations, the role of women, the availability of alternatives, long-term follow-up, health insurance coverage, misuse for human enhancement, and the potential effects on adoption. Further discussions, a broad consensus, and appropriate regulations are required before human germline genome editing is introduced into the global society.

SUMMARY

Before germline genome editing is used for disease prevention, a broad consensus must be formed by carefully discussing its ethical, legal, and social issues.

Authors+Show Affiliations

Office of Health and Safety, Hokkaido University, Sapporo 060-0808, Japan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28885275

Citation

Ishii, Tetsuya. "The Ethics of Creating Genetically Modified Children Using Genome Editing." Current Opinion in Endocrinology, Diabetes, and Obesity, vol. 24, no. 6, 2017, pp. 418-423.
Ishii T. The ethics of creating genetically modified children using genome editing. Curr Opin Endocrinol Diabetes Obes. 2017;24(6):418-423.
Ishii, T. (2017). The ethics of creating genetically modified children using genome editing. Current Opinion in Endocrinology, Diabetes, and Obesity, 24(6), 418-423. https://doi.org/10.1097/MED.0000000000000369
Ishii T. The Ethics of Creating Genetically Modified Children Using Genome Editing. Curr Opin Endocrinol Diabetes Obes. 2017;24(6):418-423. PubMed PMID: 28885275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The ethics of creating genetically modified children using genome editing. A1 - Ishii,Tetsuya, PY - 2017/9/9/pubmed PY - 2018/4/3/medline PY - 2017/9/9/entrez SP - 418 EP - 423 JF - Current opinion in endocrinology, diabetes, and obesity JO - Curr Opin Endocrinol Diabetes Obes VL - 24 IS - 6 N2 - PURPOSE OF REVIEW: To review the recent ethical, legal, and social issues surrounding human reproduction involving germline genome editing. RECENT FINDINGS: Genome editing techniques, such as CRISPR/Cas9, have facilitated genetic modification in human embryos. The most likely purpose of germline genome editing is the prevention of serious genetic disease in offspring. However, complex issues still remain, including irremediable risks to fetuses and future generations, the role of women, the availability of alternatives, long-term follow-up, health insurance coverage, misuse for human enhancement, and the potential effects on adoption. Further discussions, a broad consensus, and appropriate regulations are required before human germline genome editing is introduced into the global society. SUMMARY: Before germline genome editing is used for disease prevention, a broad consensus must be formed by carefully discussing its ethical, legal, and social issues. SN - 1752-2978 UR - https://www.unboundmedicine.com/medline/citation/28885275/The_ethics_of_creating_genetically_modified_children_using_genome_editing_ L2 - http://dx.doi.org/10.1097/MED.0000000000000369 DB - PRIME DP - Unbound Medicine ER -