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Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and incretin response to a high-carbohydrate meal in healthy men and women.
J Nutr Biochem 2017; 49:53-62JN

Abstract

Postprandial glycemic responses to meals are inhibited by polyphenol-rich plant foods. Combinations of polyphenols may be particularly effective through complementary mechanisms. A randomized, controlled, double-blinded cross-over trial was conducted in healthy volunteers to test the hypothesis that apple and blackcurrant polyphenol-rich drinks would reduce postprandial blood glucose concentrations. Secondary outcomes included insulin and glucose-dependent insulinotropic polypeptide (GIP) secretion. Twenty men (mean age 26 y, SD 8) and 5 postmenopausal women (mean age 57 y, SD 3) consumed a placebo drink (CON) and 2 polyphenol-rich drinks containing fruit extracts: either 1200 mg apple polyphenols (AE), or 600 mg apple polyphenols+600 mg blackcurrant anthocyanins (AE+BE), in random order with a starch and sucrose meal. Incremental areas under the curve (iAUC) for plasma glucose concentrations were lower following AE+BE over 0-30 and 0-120 min compared with CON; mean differences (95% CI) -32 mmol/L·min (-41, -22, P<.0005) and -52 mmol/L min (-94, -9, P<.05), respectively. AE significantly reduced iAUC 0-30 min (mean difference -26 mmol/L min, -35, -18, P<.0005) compared with CON, but the difference over 120 min was not significant. Postprandial insulin, C-peptide and GIP concentrations were significantly reduced relative to CON. A dose response inhibition of glucose transport was demonstrated in Caco-2 cells, including total and GLUT-mediated transport, and SGLT1-mediated glucose transport was strongly inhibited at all doses in Xenopus oocytes, following 10 min incubation with 0.125-4 mg apple polyphenols/ml. In conclusion, ingestion of apple and blackcurrant polyphenols decreased postprandial glycemia, which may be partly related to inhibition of intestinal glucose transport.

Authors+Show Affiliations

Diabetes & Nutritional Sciences Division, Faculty of Life Sciences and Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.Diabetes & Nutritional Sciences Division, Faculty of Life Sciences and Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.Diabetes & Nutritional Sciences Division, Faculty of Life Sciences and Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.Diabetes & Nutritional Sciences Division, Faculty of Life Sciences and Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.Diabetes & Nutritional Sciences Division, Faculty of Life Sciences and Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.Diabetes & Nutritional Sciences Division, Faculty of Life Sciences and Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.Diabetes & Nutritional Sciences Division, Faculty of Life Sciences and Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.Diabetes & Nutritional Sciences Division, Faculty of Life Sciences and Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK. Electronic address: wendy.hall@kcl.ac.uk.

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28886437

Citation

Castro-Acosta, Monica L., et al. "Apple and Blackcurrant Polyphenol-rich Drinks Decrease Postprandial Glucose, Insulin and Incretin Response to a High-carbohydrate Meal in Healthy Men and Women." The Journal of Nutritional Biochemistry, vol. 49, 2017, pp. 53-62.
Castro-Acosta ML, Stone SG, Mok JE, et al. Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and incretin response to a high-carbohydrate meal in healthy men and women. J Nutr Biochem. 2017;49:53-62.
Castro-Acosta, M. L., Stone, S. G., Mok, J. E., Mhajan, R. K., Fu, C. I., Lenihan-Geels, G. N., ... Hall, W. L. (2017). Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and incretin response to a high-carbohydrate meal in healthy men and women. The Journal of Nutritional Biochemistry, 49, pp. 53-62. doi:10.1016/j.jnutbio.2017.07.013.
Castro-Acosta ML, et al. Apple and Blackcurrant Polyphenol-rich Drinks Decrease Postprandial Glucose, Insulin and Incretin Response to a High-carbohydrate Meal in Healthy Men and Women. J Nutr Biochem. 2017;49:53-62. PubMed PMID: 28886437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and incretin response to a high-carbohydrate meal in healthy men and women. AU - Castro-Acosta,Monica L, AU - Stone,Stephanie G, AU - Mok,Jonathan E, AU - Mhajan,Rhia K, AU - Fu,Chi-Ieng, AU - Lenihan-Geels,Georgia N, AU - Corpe,Christopher P, AU - Hall,Wendy L, Y1 - 2017/07/27/ PY - 2017/02/08/received PY - 2017/06/26/revised PY - 2017/07/19/accepted PY - 2017/9/9/pubmed PY - 2018/5/3/medline PY - 2017/9/9/entrez KW - Apple KW - Glucose-dependent insulinotropic polypeptide KW - Insulin KW - Polyphenols KW - Postprandial blood glucose KW - Randomized controlled trial SP - 53 EP - 62 JF - The Journal of nutritional biochemistry JO - J. Nutr. Biochem. VL - 49 N2 - Postprandial glycemic responses to meals are inhibited by polyphenol-rich plant foods. Combinations of polyphenols may be particularly effective through complementary mechanisms. A randomized, controlled, double-blinded cross-over trial was conducted in healthy volunteers to test the hypothesis that apple and blackcurrant polyphenol-rich drinks would reduce postprandial blood glucose concentrations. Secondary outcomes included insulin and glucose-dependent insulinotropic polypeptide (GIP) secretion. Twenty men (mean age 26 y, SD 8) and 5 postmenopausal women (mean age 57 y, SD 3) consumed a placebo drink (CON) and 2 polyphenol-rich drinks containing fruit extracts: either 1200 mg apple polyphenols (AE), or 600 mg apple polyphenols+600 mg blackcurrant anthocyanins (AE+BE), in random order with a starch and sucrose meal. Incremental areas under the curve (iAUC) for plasma glucose concentrations were lower following AE+BE over 0-30 and 0-120 min compared with CON; mean differences (95% CI) -32 mmol/L·min (-41, -22, P<.0005) and -52 mmol/L min (-94, -9, P<.05), respectively. AE significantly reduced iAUC 0-30 min (mean difference -26 mmol/L min, -35, -18, P<.0005) compared with CON, but the difference over 120 min was not significant. Postprandial insulin, C-peptide and GIP concentrations were significantly reduced relative to CON. A dose response inhibition of glucose transport was demonstrated in Caco-2 cells, including total and GLUT-mediated transport, and SGLT1-mediated glucose transport was strongly inhibited at all doses in Xenopus oocytes, following 10 min incubation with 0.125-4 mg apple polyphenols/ml. In conclusion, ingestion of apple and blackcurrant polyphenols decreased postprandial glycemia, which may be partly related to inhibition of intestinal glucose transport. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/28886437/Apple_and_blackcurrant_polyphenol_rich_drinks_decrease_postprandial_glucose_insulin_and_incretin_response_to_a_high_carbohydrate_meal_in_healthy_men_and_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(17)30081-5 DB - PRIME DP - Unbound Medicine ER -