Tags

Type your tag names separated by a space and hit enter

Chronic kidney disease and diabetes associated with long-term outcomes in patients receiving percutaneous coronary intervention.
BMC Cardiovasc Disord. 2017 Sep 11; 17(1):242.BC

Abstract

BACKGROUND

The effect of diabetes mellitus (DM) and chronic kidney disease (CKD) on long-term outcomes in patients receiving percutaneous coronary intervention (PCI) is unclear.

METHODS

A total of 1394 patients who underwent PCI were prospectively enrolled and divided into 4 groups according to the presence or absence of DM or CKD. Baseline characteristics, risk factors, medications, and angiographic findings were compared. Determinants of long-term outcomes in patients undergoing PCI were analyzed.

RESULTS

Patients with DM and CKD had the highest all-cause mortality and cardiovascular mortality (both P < 0.01) but there were no differences existed in myocardial infarction (MI) or repeated PCI among the 4 groups (P = 0.19, P = 0.87, respectively). Patients with DM and CKD had the lowest even-free rate of all-cause mortality, cardiovascular mortality, MI, and repeated PCI (P < 0.001, P < 0.001, P < 0.001, and P = 0.002, respectively). In the Cox proportional hazard model, patients with both DM and CKD had the highest risk of all-cause mortality (HR: 3.25, 95% CI: 1.85-5.59), cardiovascular mortality (HR: 3.58, 95% CI: 1.97-6.49), MI (HR: 2.43, 95% CI: 1.23-4.08), and repeated PCI (HR: 1.79, 95% CI: 1.33-2.41). Patients with CKD alone had the second highest risk of all-cause mortality (HR: 2.04, 95% CI: 1.15-3.63), cardiovascular mortality (HR: 2.13, 95% CI: 1.13-4.01), and repeated PCI (HR: 1.47, 95% CI: 1.09-1.97).

CONCLUSIONS

DM and CKD had additive effect on adverse long-term outcomes in patients receiving PCI; CKD was a more significant adverse predictor than DM.

Authors+Show Affiliations

Division of Cardiology, Department of Medicine, Taichung Tzu Chi Hospital, The Buddhist Tzu Chi Medical foundation, Taichung, Taiwan. Department of Medicine, School of Medicine, Tzu Chi University, Hualien, Taiwan.Division of Pediatric General Medicine, Department of Pediatrics, Chang Gung Memorial Hospital at Linko, No. 5, Fu-Hsin Street, Kweishan, Taoyuan, Taiwan. College of Medicine, Chang Gung University, Taoyuan, Taiwan.Department of Pediatric Emergency Medicine, Changhua Christian Children's Hospital, Changhua, Taiwan. School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.Department of Public Health, Chung Shan Medical University, Taichung, Taiwan.Division of Pediatric General Medicine, Department of Pediatrics, Chang Gung Memorial Hospital at Linko, No. 5, Fu-Hsin Street, Kweishan, Taoyuan, Taiwan. arthur1226@gmail.com. College of Medicine, Chang Gung University, Taoyuan, Taiwan. arthur1226@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28893175

Citation

Lin, Mao-Jen, et al. "Chronic Kidney Disease and Diabetes Associated With Long-term Outcomes in Patients Receiving Percutaneous Coronary Intervention." BMC Cardiovascular Disorders, vol. 17, no. 1, 2017, p. 242.
Lin MJ, Lee J, Chen CY, et al. Chronic kidney disease and diabetes associated with long-term outcomes in patients receiving percutaneous coronary intervention. BMC Cardiovasc Disord. 2017;17(1):242.
Lin, M. J., Lee, J., Chen, C. Y., Huang, C. C., & Wu, H. P. (2017). Chronic kidney disease and diabetes associated with long-term outcomes in patients receiving percutaneous coronary intervention. BMC Cardiovascular Disorders, 17(1), 242. https://doi.org/10.1186/s12872-017-0673-4
Lin MJ, et al. Chronic Kidney Disease and Diabetes Associated With Long-term Outcomes in Patients Receiving Percutaneous Coronary Intervention. BMC Cardiovasc Disord. 2017 Sep 11;17(1):242. PubMed PMID: 28893175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic kidney disease and diabetes associated with long-term outcomes in patients receiving percutaneous coronary intervention. AU - Lin,Mao-Jen, AU - Lee,Jung, AU - Chen,Chun-Yu, AU - Huang,Chia-Chen, AU - Wu,Han-Ping, Y1 - 2017/09/11/ PY - 2017/04/27/received PY - 2017/08/27/accepted PY - 2017/9/13/entrez PY - 2017/9/13/pubmed PY - 2018/6/12/medline KW - Chronic kidney disease KW - Diabetes mellitus KW - PCI SP - 242 EP - 242 JF - BMC cardiovascular disorders JO - BMC Cardiovasc Disord VL - 17 IS - 1 N2 - BACKGROUND: The effect of diabetes mellitus (DM) and chronic kidney disease (CKD) on long-term outcomes in patients receiving percutaneous coronary intervention (PCI) is unclear. METHODS: A total of 1394 patients who underwent PCI were prospectively enrolled and divided into 4 groups according to the presence or absence of DM or CKD. Baseline characteristics, risk factors, medications, and angiographic findings were compared. Determinants of long-term outcomes in patients undergoing PCI were analyzed. RESULTS: Patients with DM and CKD had the highest all-cause mortality and cardiovascular mortality (both P < 0.01) but there were no differences existed in myocardial infarction (MI) or repeated PCI among the 4 groups (P = 0.19, P = 0.87, respectively). Patients with DM and CKD had the lowest even-free rate of all-cause mortality, cardiovascular mortality, MI, and repeated PCI (P < 0.001, P < 0.001, P < 0.001, and P = 0.002, respectively). In the Cox proportional hazard model, patients with both DM and CKD had the highest risk of all-cause mortality (HR: 3.25, 95% CI: 1.85-5.59), cardiovascular mortality (HR: 3.58, 95% CI: 1.97-6.49), MI (HR: 2.43, 95% CI: 1.23-4.08), and repeated PCI (HR: 1.79, 95% CI: 1.33-2.41). Patients with CKD alone had the second highest risk of all-cause mortality (HR: 2.04, 95% CI: 1.15-3.63), cardiovascular mortality (HR: 2.13, 95% CI: 1.13-4.01), and repeated PCI (HR: 1.47, 95% CI: 1.09-1.97). CONCLUSIONS: DM and CKD had additive effect on adverse long-term outcomes in patients receiving PCI; CKD was a more significant adverse predictor than DM. SN - 1471-2261 UR - https://www.unboundmedicine.com/medline/citation/28893175/Chronic_kidney_disease_and_diabetes_associated_with_long_term_outcomes_in_patients_receiving_percutaneous_coronary_intervention_ L2 - https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-017-0673-4 DB - PRIME DP - Unbound Medicine ER -