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Effects of daily vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients: a pilot trial.
Int J Chron Obstruct Pulmon Dis 2017; 12:2583-2592IJ

Abstract

BACKGROUND

Although vitamin D is well known for its function in calcium homeostasis and bone mineralization, several studies have shown positive effects on muscle strength and physical function. In addition, vitamin D has been associated with pulmonary function and the incidence of airway infections. As vitamin D deficiency is highly prevalent in chronic obstructive pulmonary disease (COPD) patients, supplementation might have a beneficial effect in these patients.

OBJECTIVE

To assess the effect of vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients. Secondary outcomes are pulmonary function, handgrip strength, exacerbation rate, and quality of life.

METHODS

We performed a randomized, double-blind, placebo-controlled pilot trial. Participants were randomly allocated to receive 1,200 IU vitamin D3 per day (n=24) or placebo (n=26) during 6 months. Study visits were conducted at baseline, and at 3 and 6 months after randomization. During the visits, blood was collected, respiratory muscle strength was measured (maximum inspiratory and expiratory pressure), physical performance and 6-minute walking tests were performed, and handgrip strength and pulmonary function were assessed. In addition, participants kept a diary card in which they registered respiratory symptoms.

RESULTS

At baseline, the mean (standard deviation [SD]) serum 25-hydroxyvitamin D (25(OH)D) concentration (nmol/L) was 42.3 (15.2) in the vitamin D group and 40.6 (17.0) in the placebo group. Participants with vitamin D supplementation had a larger increase in serum 25(OH)D compared to the placebo group after 6 months (mean difference (SD): +52.8 (29.8) vs +12.3 (25.1), P<0.001). Primary outcomes, respiratory muscle strength and physical performance, did not differ between the groups after 6 months. In addition, no differences were found in the 6-minute walking test results, handgrip strength, pulmonary function, exacerbation rate, or quality of life.

CONCLUSION

Vitamin D supplementation did not affect (respiratory) muscle strength or physical performance in this pilot trial in vitamin D-deficient COPD patients.

Authors+Show Affiliations

Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam.Department of Pulmonary Diseases, Northwest Hospital group, Alkmaar.Department of Pulmonary Diseases, Northwest Hospital group, Alkmaar.Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, the Netherlands.Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam.Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam.Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

28894361

Citation

Rafiq, Rachida, et al. "Effects of Daily Vitamin D Supplementation On Respiratory Muscle Strength and Physical Performance in Vitamin D-deficient COPD Patients: a Pilot Trial." International Journal of Chronic Obstructive Pulmonary Disease, vol. 12, 2017, pp. 2583-2592.
Rafiq R, Prins HJ, Boersma WG, et al. Effects of daily vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients: a pilot trial. Int J Chron Obstruct Pulmon Dis. 2017;12:2583-2592.
Rafiq, R., Prins, H. J., Boersma, W. G., Daniels, J. M., den Heijer, M., Lips, P., & de Jongh, R. T. (2017). Effects of daily vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients: a pilot trial. International Journal of Chronic Obstructive Pulmonary Disease, 12, pp. 2583-2592. doi:10.2147/COPD.S132117.
Rafiq R, et al. Effects of Daily Vitamin D Supplementation On Respiratory Muscle Strength and Physical Performance in Vitamin D-deficient COPD Patients: a Pilot Trial. Int J Chron Obstruct Pulmon Dis. 2017;12:2583-2592. PubMed PMID: 28894361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of daily vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients: a pilot trial. AU - Rafiq,Rachida, AU - Prins,Hendrik J, AU - Boersma,Wim G, AU - Daniels,Johannes Ma, AU - den Heijer,Martin, AU - Lips,Paul, AU - de Jongh,Renate T, Y1 - 2017/08/28/ PY - 2017/9/13/entrez PY - 2017/9/13/pubmed PY - 2018/6/5/medline KW - chronic obstructive pulmonary disease KW - muscle strength KW - physical performance KW - pulmonary function KW - vitamin D SP - 2583 EP - 2592 JF - International journal of chronic obstructive pulmonary disease JO - Int J Chron Obstruct Pulmon Dis VL - 12 N2 - BACKGROUND: Although vitamin D is well known for its function in calcium homeostasis and bone mineralization, several studies have shown positive effects on muscle strength and physical function. In addition, vitamin D has been associated with pulmonary function and the incidence of airway infections. As vitamin D deficiency is highly prevalent in chronic obstructive pulmonary disease (COPD) patients, supplementation might have a beneficial effect in these patients. OBJECTIVE: To assess the effect of vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients. Secondary outcomes are pulmonary function, handgrip strength, exacerbation rate, and quality of life. METHODS: We performed a randomized, double-blind, placebo-controlled pilot trial. Participants were randomly allocated to receive 1,200 IU vitamin D3 per day (n=24) or placebo (n=26) during 6 months. Study visits were conducted at baseline, and at 3 and 6 months after randomization. During the visits, blood was collected, respiratory muscle strength was measured (maximum inspiratory and expiratory pressure), physical performance and 6-minute walking tests were performed, and handgrip strength and pulmonary function were assessed. In addition, participants kept a diary card in which they registered respiratory symptoms. RESULTS: At baseline, the mean (standard deviation [SD]) serum 25-hydroxyvitamin D (25(OH)D) concentration (nmol/L) was 42.3 (15.2) in the vitamin D group and 40.6 (17.0) in the placebo group. Participants with vitamin D supplementation had a larger increase in serum 25(OH)D compared to the placebo group after 6 months (mean difference (SD): +52.8 (29.8) vs +12.3 (25.1), P<0.001). Primary outcomes, respiratory muscle strength and physical performance, did not differ between the groups after 6 months. In addition, no differences were found in the 6-minute walking test results, handgrip strength, pulmonary function, exacerbation rate, or quality of life. CONCLUSION: Vitamin D supplementation did not affect (respiratory) muscle strength or physical performance in this pilot trial in vitamin D-deficient COPD patients. SN - 1178-2005 UR - http://www.unboundmedicine.com/medline/citation/28894361/Effects_of_daily_vitamin_D_supplementation_on_respiratory_muscle_strength_and_physical_performance_in_vitamin_D_deficient_COPD_patients:_a_pilot_trial_ L2 - https://dx.doi.org/10.2147/COPD.S132117 DB - PRIME DP - Unbound Medicine ER -