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A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4.
Comput Math Methods Med. 2017; 2017:5285810.CM

Abstract

The Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans. MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally expressed in endothelial and epithelial cells and has been shown to be present on cultured human nonciliated bronchiolar epithelium cells. In this paper, a class of novel four-dimensional dynamic model describing the infection of MERS-CoV is given, and then global stability of the equilibria of the model is discussed. Our results show that the spread of MERS-CoV can also be controlled by decreasing the expression rate of DPP4.

Authors+Show Affiliations

Department of Applied Mathematics, School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, China.Department of Applied Mathematics, School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, China.Department of Applied Mathematics, School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28894474

Citation

Tang, Siming, et al. "A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4." Computational and Mathematical Methods in Medicine, vol. 2017, 2017, p. 5285810.
Tang S, Ma W, Bai P. A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4. Comput Math Methods Med. 2017;2017:5285810.
Tang, S., Ma, W., & Bai, P. (2017). A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4. Computational and Mathematical Methods in Medicine, 2017, 5285810. https://doi.org/10.1155/2017/5285810
Tang S, Ma W, Bai P. A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4. Comput Math Methods Med. 2017;2017:5285810. PubMed PMID: 28894474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4. AU - Tang,Siming, AU - Ma,Wanbiao, AU - Bai,Peifan, Y1 - 2017/08/15/ PY - 2017/04/19/received PY - 2017/07/03/accepted PY - 2017/9/13/entrez PY - 2017/9/13/pubmed PY - 2017/12/5/medline SP - 5285810 EP - 5285810 JF - Computational and mathematical methods in medicine JO - Comput Math Methods Med VL - 2017 N2 - The Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans. MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally expressed in endothelial and epithelial cells and has been shown to be present on cultured human nonciliated bronchiolar epithelium cells. In this paper, a class of novel four-dimensional dynamic model describing the infection of MERS-CoV is given, and then global stability of the equilibria of the model is discussed. Our results show that the spread of MERS-CoV can also be controlled by decreasing the expression rate of DPP4. SN - 1748-6718 UR - https://www.unboundmedicine.com/medline/citation/28894474/A_Novel_Dynamic_Model_Describing_the_Spread_of_the_MERS_CoV_and_the_Expression_of_Dipeptidyl_Peptidase_4_ L2 - https://doi.org/10.1155/2017/5285810 DB - PRIME DP - Unbound Medicine ER -