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Thyroid Storm: A Japanese Perspective.
Thyroid. 2018 01; 28(1):32-40.T

Abstract

BACKGROUND

Thyroid storm (TS) is life threatening. In the mid-2000s, its incidence was poorly defined, peer-reviewed diagnostic criteria were not available, and management and treatment did not seem to be verified based upon evidence and latest advances in medicine.

METHODS

First, diagnostic criteria were developed based on 99 patients in the literature and seven patients in this study. Then, initial and follow-up surveys were conducted from 2004 through 2008, targeting all hospitals in Japan to obtain and verify information on patients who met diagnostic criteria for TS. Based on these data, the diagnostic criteria were revised, and management and treatment guidelines were created.

RESULTS

The incidence of TS in hospitalized patients in Japan was estimated to be 0.20 per 100,000 per year and 0.22% of all thyrotoxic patients. The mortality rate was 10.7%. Multiple organ failure was the most common cause of death, followed by congestive heart failure, respiratory failure, and arrhythmia. In the final diagnostic criteria for TS, the definition of jaundice as serum bilirubin concentration >3 mg/dL was added. Based upon nationwide surveys and the latest information, guidelines for the management and treatment for TS were extensively revised and algorithms were developed.

CONCLUSIONS

TS remains a life-threatening disorder, with >10% mortality in Japan. New peer-reviewed diagnostic criteria for TS are presented and its clinical features, prognosis, and incidence are clarified based on nationwide surveys. Furthermore, this information helped to establish detailed guidelines for the management and treatment of TS. A prospective prognostic study to validate the guidelines is eagerly anticipated.

Authors+Show Affiliations

The First Department of Medicine, Wakayama Medical University , Wakayama, Japan .

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

28899229

Citation

Akamizu, Takashi. "Thyroid Storm: a Japanese Perspective." Thyroid : Official Journal of the American Thyroid Association, vol. 28, no. 1, 2018, pp. 32-40.
Akamizu T. Thyroid Storm: A Japanese Perspective. Thyroid. 2018;28(1):32-40.
Akamizu, T. (2018). Thyroid Storm: A Japanese Perspective. Thyroid : Official Journal of the American Thyroid Association, 28(1), 32-40. https://doi.org/10.1089/thy.2017.0243
Akamizu T. Thyroid Storm: a Japanese Perspective. Thyroid. 2018;28(1):32-40. PubMed PMID: 28899229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyroid Storm: A Japanese Perspective. A1 - Akamizu,Takashi, Y1 - 2017/10/05/ PY - 2017/9/14/pubmed PY - 2018/12/12/medline PY - 2017/9/14/entrez KW - diagnostic criteria KW - guideline KW - management KW - thyroid crisis KW - treatment SP - 32 EP - 40 JF - Thyroid : official journal of the American Thyroid Association JO - Thyroid VL - 28 IS - 1 N2 - BACKGROUND: Thyroid storm (TS) is life threatening. In the mid-2000s, its incidence was poorly defined, peer-reviewed diagnostic criteria were not available, and management and treatment did not seem to be verified based upon evidence and latest advances in medicine. METHODS: First, diagnostic criteria were developed based on 99 patients in the literature and seven patients in this study. Then, initial and follow-up surveys were conducted from 2004 through 2008, targeting all hospitals in Japan to obtain and verify information on patients who met diagnostic criteria for TS. Based on these data, the diagnostic criteria were revised, and management and treatment guidelines were created. RESULTS: The incidence of TS in hospitalized patients in Japan was estimated to be 0.20 per 100,000 per year and 0.22% of all thyrotoxic patients. The mortality rate was 10.7%. Multiple organ failure was the most common cause of death, followed by congestive heart failure, respiratory failure, and arrhythmia. In the final diagnostic criteria for TS, the definition of jaundice as serum bilirubin concentration >3 mg/dL was added. Based upon nationwide surveys and the latest information, guidelines for the management and treatment for TS were extensively revised and algorithms were developed. CONCLUSIONS: TS remains a life-threatening disorder, with >10% mortality in Japan. New peer-reviewed diagnostic criteria for TS are presented and its clinical features, prognosis, and incidence are clarified based on nationwide surveys. Furthermore, this information helped to establish detailed guidelines for the management and treatment of TS. A prospective prognostic study to validate the guidelines is eagerly anticipated. SN - 1557-9077 UR - https://www.unboundmedicine.com/medline/citation/28899229/Thyroid_Storm:_A_Japanese_Perspective. DB - PRIME DP - Unbound Medicine ER -
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