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Benign metastasizing leiomyoma presenting as multiple cystic pulmonary nodules: a case report.
BMC Womens Health. 2017 Sep 12; 17(1):81.BW

Abstract

BACKGROUND

Benign metastatic leiomyoma (BML) is an extremely rare disease. Although uterine leiomyomas are benign histologically, they can metastasize to distant sites. While the incidence is very low, the lung is the organ most frequently affected by BML. Pulmonary BML usually presents as numerous well-defined nodules of various sizes, while the cavitary or cystic features in the nodules are rarely observed on radiologic images.

CASE PRESENTATION

A 52-year-old woman complained of cough and dyspnea for one month. She had been previously diagnosed with uterine leiomyoma and had undergone total hysterectomy about 14 years prior. High-resolution computed tomography (CT) images showed that there were multiple cystic nodules of various sizes in both lungs. Pathologic examination revealed that the pulmonary nodule had complex branching glandular structures lined by a single layer of simple cuboidal to columnar epithelium that was surrounded by abundant spindle cells. Additional immunohistochemistry data suggested that pulmonary nodule diagnosis was BML-associated uterine leiomyoma.

CONCLUSION

In this report, we introduce an interesting case of pulmonary BML that presented as a combination of various kinds of nodules including simple round nodules, simple cysts, and cysts with a solid portion, which are very rare radiologic features of BML in lung. In addition, when the patient is a woman of reproductive age, physicians should meticulously review the gynecological history and suspect BML when there are various cystic pulmonary lesions.

Authors+Show Affiliations

Department of Internal Medicine, Chonbuk National University Medical School, San 2-20, Geumam-dong, Deokjin-gu, Jeonju, Jeonbuk, 561-180, South Korea. Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, South Korea.Department of Internal Medicine, Chonbuk National University Medical School, San 2-20, Geumam-dong, Deokjin-gu, Jeonju, Jeonbuk, 561-180, South Korea.Department of Internal Medicine, Chonbuk National University Medical School, San 2-20, Geumam-dong, Deokjin-gu, Jeonju, Jeonbuk, 561-180, South Korea.Department of Pathology, Chonbuk National University Medical School, Jeonju, South Korea. Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, South Korea.Department of Internal Medicine, Chonbuk National University Medical School, San 2-20, Geumam-dong, Deokjin-gu, Jeonju, Jeonbuk, 561-180, South Korea. Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, South Korea.Department of Internal Medicine, Chonbuk National University Medical School, San 2-20, Geumam-dong, Deokjin-gu, Jeonju, Jeonbuk, 561-180, South Korea. leeyc@jbnu.ac.kr. Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, South Korea. leeyc@jbnu.ac.kr.Department of Internal Medicine, Chonbuk National University Medical School, San 2-20, Geumam-dong, Deokjin-gu, Jeonju, Jeonbuk, 561-180, South Korea. sori@jbnu.ac.kr. Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, South Korea. sori@jbnu.ac.kr.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28899426

Citation

Choe, Yeong Hun, et al. "Benign Metastasizing Leiomyoma Presenting as Multiple Cystic Pulmonary Nodules: a Case Report." BMC Women's Health, vol. 17, no. 1, 2017, p. 81.
Choe YH, Jeon SY, Lee YC, et al. Benign metastasizing leiomyoma presenting as multiple cystic pulmonary nodules: a case report. BMC Womens Health. 2017;17(1):81.
Choe, Y. H., Jeon, S. Y., Lee, Y. C., Chung, M. J., Park, S. Y., Lee, Y. C., & Kim, S. R. (2017). Benign metastasizing leiomyoma presenting as multiple cystic pulmonary nodules: a case report. BMC Women's Health, 17(1), 81. https://doi.org/10.1186/s12905-017-0435-6
Choe YH, et al. Benign Metastasizing Leiomyoma Presenting as Multiple Cystic Pulmonary Nodules: a Case Report. BMC Womens Health. 2017 Sep 12;17(1):81. PubMed PMID: 28899426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benign metastasizing leiomyoma presenting as multiple cystic pulmonary nodules: a case report. AU - Choe,Yeong Hun, AU - Jeon,So Yeon, AU - Lee,Yoon Chae, AU - Chung,Myung Ja, AU - Park,Seung Yong, AU - Lee,Yong Chul, AU - Kim,So Ri, Y1 - 2017/09/12/ PY - 2015/09/23/received PY - 2017/08/29/accepted PY - 2017/9/14/entrez PY - 2017/9/14/pubmed PY - 2018/5/22/medline KW - Benign metastatic leiomyoma KW - Lung KW - Multiple cysts SP - 81 EP - 81 JF - BMC women's health JO - BMC Womens Health VL - 17 IS - 1 N2 - BACKGROUND: Benign metastatic leiomyoma (BML) is an extremely rare disease. Although uterine leiomyomas are benign histologically, they can metastasize to distant sites. While the incidence is very low, the lung is the organ most frequently affected by BML. Pulmonary BML usually presents as numerous well-defined nodules of various sizes, while the cavitary or cystic features in the nodules are rarely observed on radiologic images. CASE PRESENTATION: A 52-year-old woman complained of cough and dyspnea for one month. She had been previously diagnosed with uterine leiomyoma and had undergone total hysterectomy about 14 years prior. High-resolution computed tomography (CT) images showed that there were multiple cystic nodules of various sizes in both lungs. Pathologic examination revealed that the pulmonary nodule had complex branching glandular structures lined by a single layer of simple cuboidal to columnar epithelium that was surrounded by abundant spindle cells. Additional immunohistochemistry data suggested that pulmonary nodule diagnosis was BML-associated uterine leiomyoma. CONCLUSION: In this report, we introduce an interesting case of pulmonary BML that presented as a combination of various kinds of nodules including simple round nodules, simple cysts, and cysts with a solid portion, which are very rare radiologic features of BML in lung. In addition, when the patient is a woman of reproductive age, physicians should meticulously review the gynecological history and suspect BML when there are various cystic pulmonary lesions. SN - 1472-6874 UR - https://www.unboundmedicine.com/medline/citation/28899426/Benign_metastasizing_leiomyoma_presenting_as_multiple_cystic_pulmonary_nodules:_a_case_report_ L2 - https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-017-0435-6 DB - PRIME DP - Unbound Medicine ER -