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Serum 25-hydroxyvitamin D concentrations and lung cancer risk in never-smoking postmenopausal women.
Cancer Causes Control. 2017 Oct; 28(10):1053-1063.CC

Abstract

PURPOSE

Vitamin D has been implicated in lowering lung cancer risk, but serological data on the association among never-smoking women are limited. We report results examining the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with lung cancer risk among female never smokers. We also examined whether the association was modified by vitamin D supplementation and serum vitamin A concentrations.

METHODS

In the Women's Health Initiative, including the calcium/vitamin D (CaD) Trial, we selected 298 incident cases [191 non-small cell lung cancer (NSCLC) including 170 adenocarcinoma] and 298 matched controls of never smokers. Baseline serum 25(OH)D was assayed by a chemiluminescent method. Logistic regression was used to estimate odds ratios (ORs) for quartiles and predefined clinical cutoffs of serum 25(OH)D concentrations.

RESULTS

Comparing quartiles 4 versus 1 of serum 25(OH)D concentrations, ORs were 1.06 [95% confidence interval (CI) 0.61-1.84] for all lung cancer, 0.94 (95% CI 0.52-1.69) for NSCLC, and 0.91 (95% CI 0.49-1.68) for adenocarcinoma. Comparing serum 25(OH)D ≥ 75 (high) versus <30 nmol/L (deficient), ORs were 0.76 (95% CI 0.31-1.84) for all lung cancer, 0.71 (95% CI 0.27-1.86) for NSCLC, and 0.81 (95% CI 0.31-2.14) for adenocarcinoma. There is suggestive evidence that CaD supplementation (1 g calcium + 400 IU D3/day) and a high level of circulating vitamin A may modify the associations of 25(OH)D with lung cancer overall and subtypes (p interaction <0.10).

CONCLUSIONS

In this group of never-smoking postmenopausal women, the results did not support the hypothesis of an association between serum 25(OH)D and lung cancer risk.

Authors+Show Affiliations

Department of Epidemiology, University of Florida, 2004 Mowry Road, 4th Floor, RM4213, P. O. Box 100231, Gainesville, FL, 32610, USA. tingyuan.cheng@ufl.edu.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.Feinstein Institute for Medical Research, Manhasset, NY, USA. Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.Department of Nutrition Science, Purdue University, West Lafayette, IN, USA.City of Hope National Medical Center, Duarte, CA, USA.Department of Epidemiology and Environment Health, University at Buffalo, The State University of New York, Buffalo, NY, USA.Division of Biostatistics, Department of Public Health Sciences, University of California-Davis, Davis, CA, USA.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28900765

Citation

Cheng, Ting-Yuan David, et al. "Serum 25-hydroxyvitamin D Concentrations and Lung Cancer Risk in Never-smoking Postmenopausal Women." Cancer Causes & Control : CCC, vol. 28, no. 10, 2017, pp. 1053-1063.
Cheng TD, Song X, Beresford SAA, et al. Serum 25-hydroxyvitamin D concentrations and lung cancer risk in never-smoking postmenopausal women. Cancer Causes Control. 2017;28(10):1053-1063.
Cheng, T. D., Song, X., Beresford, S. A. A., Ho, G. Y. F., Johnson, K. C., Datta, M., Chlebowski, R. T., Wactawski-Wende, J., Qi, L., & Neuhouser, M. L. (2017). Serum 25-hydroxyvitamin D concentrations and lung cancer risk in never-smoking postmenopausal women. Cancer Causes & Control : CCC, 28(10), 1053-1063. https://doi.org/10.1007/s10552-017-0956-1
Cheng TD, et al. Serum 25-hydroxyvitamin D Concentrations and Lung Cancer Risk in Never-smoking Postmenopausal Women. Cancer Causes Control. 2017;28(10):1053-1063. PubMed PMID: 28900765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D concentrations and lung cancer risk in never-smoking postmenopausal women. AU - Cheng,Ting-Yuan David, AU - Song,Xiaoling, AU - Beresford,Shirley A A, AU - Ho,Gloria Y F, AU - Johnson,Karen C, AU - Datta,Mridul, AU - Chlebowski,Rowan T, AU - Wactawski-Wende,Jean, AU - Qi,Lihong, AU - Neuhouser,Marian L, Y1 - 2017/09/12/ PY - 2016/08/18/received PY - 2017/09/07/accepted PY - 2017/9/14/pubmed PY - 2018/5/18/medline PY - 2017/9/14/entrez KW - 25-Hydroxyvitamin D KW - Histology KW - Lung cancer KW - Never smokers KW - Postmenopausal women SP - 1053 EP - 1063 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 28 IS - 10 N2 - PURPOSE: Vitamin D has been implicated in lowering lung cancer risk, but serological data on the association among never-smoking women are limited. We report results examining the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with lung cancer risk among female never smokers. We also examined whether the association was modified by vitamin D supplementation and serum vitamin A concentrations. METHODS: In the Women's Health Initiative, including the calcium/vitamin D (CaD) Trial, we selected 298 incident cases [191 non-small cell lung cancer (NSCLC) including 170 adenocarcinoma] and 298 matched controls of never smokers. Baseline serum 25(OH)D was assayed by a chemiluminescent method. Logistic regression was used to estimate odds ratios (ORs) for quartiles and predefined clinical cutoffs of serum 25(OH)D concentrations. RESULTS: Comparing quartiles 4 versus 1 of serum 25(OH)D concentrations, ORs were 1.06 [95% confidence interval (CI) 0.61-1.84] for all lung cancer, 0.94 (95% CI 0.52-1.69) for NSCLC, and 0.91 (95% CI 0.49-1.68) for adenocarcinoma. Comparing serum 25(OH)D ≥ 75 (high) versus <30 nmol/L (deficient), ORs were 0.76 (95% CI 0.31-1.84) for all lung cancer, 0.71 (95% CI 0.27-1.86) for NSCLC, and 0.81 (95% CI 0.31-2.14) for adenocarcinoma. There is suggestive evidence that CaD supplementation (1 g calcium + 400 IU D3/day) and a high level of circulating vitamin A may modify the associations of 25(OH)D with lung cancer overall and subtypes (p interaction <0.10). CONCLUSIONS: In this group of never-smoking postmenopausal women, the results did not support the hypothesis of an association between serum 25(OH)D and lung cancer risk. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/28900765/Serum_25_hydroxyvitamin_D_concentrations_and_lung_cancer_risk_in_never_smoking_postmenopausal_women_ L2 - https://doi.org/10.1007/s10552-017-0956-1 DB - PRIME DP - Unbound Medicine ER -