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Dietary Fiber Intake and Risk of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study of Men.
Epidemiology. 2018 03; 29(2):254-260.E

Abstract

BACKGROUND

The limited literature suggests that dietary fiber intake from whole grains, fruits, and vegetables is negatively associated with chronic obstructive pulmonary disease (COPD) via fiber's anti-inflammatory properties. Therefore, we investigated the association between total fiber and fiber sources and risk of COPD in the population-based prospective Cohort of Swedish Men (45,058 men, ages 45-79 years) with no history of COPD at baseline.

METHODS

Dietary fiber intake was assessed with a self-administered questionnaire in 1997 and was energy adjusted using the residual method. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (95% CIs) adjusted for potential confounders.

RESULTS

During a mean follow-up of 13.1 years (1998-2012), 1,982 incident cases of COPD were ascertained via linkage to the Swedish health registers. A strong inverse association between total fiber intake (≥36.8 vs. <23.7 g/day) and COPD was observed in current smokers (hazard ratio [HR] = 0.54; 95% confidence interval [CI] = 0.43, 0.67) and ex-smokers (HR = 0.62; 95% CI = 0.50, 0.78) but not in never smokers (HR = 0.93; 95% CI = 0.60, 1.45; P interaction = 0.04). For cereal fiber, HRs for highest versus lowest quintile were 0.62 (95% CI = 0.51, 0.77; P trend < 0.001) in current smokers and 0.66 (95% CI = 0.52, 0.82; P trend < 0.001) in ex-smokers; for fruit fiber, the HR was 0.65 (95% CI = 0.52, 0.81; P trend < 0.001) in current smokers and 0.77 (95% CI = 0.61, 0.98; P trend = 0.17) in ex-smokers; and for vegetable fiber, it was 0.71 (95% CI = 0.57, 0.88; P trend = 0.003) in current smokers and 0.92 (95% CI = 0.71, 1.19; P trend = 0.48) in ex-smokers.

CONCLUSIONS

Our findings indicate that high fiber intake was inversely associated with COPD incidence in men who are current or ex-smokers.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28901975

Citation

Kaluza, Joanna, et al. "Dietary Fiber Intake and Risk of Chronic Obstructive Pulmonary Disease: a Prospective Cohort Study of Men." Epidemiology (Cambridge, Mass.), vol. 29, no. 2, 2018, pp. 254-260.
Kaluza J, Harris H, Wallin A, et al. Dietary Fiber Intake and Risk of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study of Men. Epidemiology. 2018;29(2):254-260.
Kaluza, J., Harris, H., Wallin, A., Linden, A., & Wolk, A. (2018). Dietary Fiber Intake and Risk of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study of Men. Epidemiology (Cambridge, Mass.), 29(2), 254-260. https://doi.org/10.1097/EDE.0000000000000750
Kaluza J, et al. Dietary Fiber Intake and Risk of Chronic Obstructive Pulmonary Disease: a Prospective Cohort Study of Men. Epidemiology. 2018;29(2):254-260. PubMed PMID: 28901975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Fiber Intake and Risk of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study of Men. AU - Kaluza,Joanna, AU - Harris,Holly, AU - Wallin,Alice, AU - Linden,Anders, AU - Wolk,Alicja, PY - 2017/9/14/pubmed PY - 2019/1/12/medline PY - 2017/9/14/entrez SP - 254 EP - 260 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 29 IS - 2 N2 - BACKGROUND: The limited literature suggests that dietary fiber intake from whole grains, fruits, and vegetables is negatively associated with chronic obstructive pulmonary disease (COPD) via fiber's anti-inflammatory properties. Therefore, we investigated the association between total fiber and fiber sources and risk of COPD in the population-based prospective Cohort of Swedish Men (45,058 men, ages 45-79 years) with no history of COPD at baseline. METHODS: Dietary fiber intake was assessed with a self-administered questionnaire in 1997 and was energy adjusted using the residual method. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (95% CIs) adjusted for potential confounders. RESULTS: During a mean follow-up of 13.1 years (1998-2012), 1,982 incident cases of COPD were ascertained via linkage to the Swedish health registers. A strong inverse association between total fiber intake (≥36.8 vs. <23.7 g/day) and COPD was observed in current smokers (hazard ratio [HR] = 0.54; 95% confidence interval [CI] = 0.43, 0.67) and ex-smokers (HR = 0.62; 95% CI = 0.50, 0.78) but not in never smokers (HR = 0.93; 95% CI = 0.60, 1.45; P interaction = 0.04). For cereal fiber, HRs for highest versus lowest quintile were 0.62 (95% CI = 0.51, 0.77; P trend < 0.001) in current smokers and 0.66 (95% CI = 0.52, 0.82; P trend < 0.001) in ex-smokers; for fruit fiber, the HR was 0.65 (95% CI = 0.52, 0.81; P trend < 0.001) in current smokers and 0.77 (95% CI = 0.61, 0.98; P trend = 0.17) in ex-smokers; and for vegetable fiber, it was 0.71 (95% CI = 0.57, 0.88; P trend = 0.003) in current smokers and 0.92 (95% CI = 0.71, 1.19; P trend = 0.48) in ex-smokers. CONCLUSIONS: Our findings indicate that high fiber intake was inversely associated with COPD incidence in men who are current or ex-smokers. SN - 1531-5487 UR - https://www.unboundmedicine.com/medline/citation/28901975/Dietary_Fiber_Intake_and_Risk_of_Chronic_Obstructive_Pulmonary_Disease:_A_Prospective_Cohort_Study_of_Men_ L2 - http://dx.doi.org/10.1097/EDE.0000000000000750 DB - PRIME DP - Unbound Medicine ER -