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Biomineralized Conductive PEDOT: PSS-Coated PLA/PHBV/HA Nanofibrous Membranes.
ASAIO J. 2018 May/Jun; 64(3):415-423.AJ

Abstract

Conductive materials are potential candidates for developing bone tissue engineering scaffolds as they are nontoxic and can enhance bone tissue regeneration. Their bioactivity can be enhanced by depositing biomineralization in simulated body fluid (SBF). In the current study, a composite electrospun membrane made up of poly(lactic) acid, poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and hydroxyapatite was fabricated using an electrospinning method. The fabricated membranes were dip-coated with a conductive polymer solution, poly(3,4-ethylenedioxythiophene) poly(4-styrenesulfonate), to induce conductivity. Characterization of the membranes based on characteristics such as morphology, chemical bonding, and wettability was conducted using scanning electron microscopy, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, attenuated total reflectance Fourier transform infrared spectroscopy, and contact angle measurement. From the results, biomineralization of both coated and noncoated composite membranes was observed on the surface of nanofibers after 21 days in SBF. The membranes provide a superhydrophilic surface as shown by the contact angle. In conclusion, this biomimetic electrospun composite membrane could be used to further support cell growth for bone tissue engineering application.

Authors+Show Affiliations

From the Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, Johor, Malaysia.From the Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, Johor, Malaysia.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28901994

Citation

Hassan, Mohd Izzat, et al. "Biomineralized Conductive PEDOT: PSS-Coated PLA/PHBV/HA Nanofibrous Membranes." ASAIO Journal (American Society for Artificial Internal Organs : 1992), vol. 64, no. 3, 2018, pp. 415-423.
Hassan MI, Masnawi NN, Sultana N. Biomineralized Conductive PEDOT: PSS-Coated PLA/PHBV/HA Nanofibrous Membranes. ASAIO J. 2018;64(3):415-423.
Hassan, M. I., Masnawi, N. N., & Sultana, N. (2018). Biomineralized Conductive PEDOT: PSS-Coated PLA/PHBV/HA Nanofibrous Membranes. ASAIO Journal (American Society for Artificial Internal Organs : 1992), 64(3), 415-423. https://doi.org/10.1097/MAT.0000000000000655
Hassan MI, Masnawi NN, Sultana N. Biomineralized Conductive PEDOT: PSS-Coated PLA/PHBV/HA Nanofibrous Membranes. ASAIO J. 2018;64(3):415-423. PubMed PMID: 28901994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomineralized Conductive PEDOT: PSS-Coated PLA/PHBV/HA Nanofibrous Membranes. AU - Hassan,Mohd Izzat, AU - Masnawi,Noor Nabilah, AU - Sultana,Naznin, PY - 2017/9/14/pubmed PY - 2019/4/20/medline PY - 2017/9/14/entrez SP - 415 EP - 423 JF - ASAIO journal (American Society for Artificial Internal Organs : 1992) JO - ASAIO J. VL - 64 IS - 3 N2 - Conductive materials are potential candidates for developing bone tissue engineering scaffolds as they are nontoxic and can enhance bone tissue regeneration. Their bioactivity can be enhanced by depositing biomineralization in simulated body fluid (SBF). In the current study, a composite electrospun membrane made up of poly(lactic) acid, poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and hydroxyapatite was fabricated using an electrospinning method. The fabricated membranes were dip-coated with a conductive polymer solution, poly(3,4-ethylenedioxythiophene) poly(4-styrenesulfonate), to induce conductivity. Characterization of the membranes based on characteristics such as morphology, chemical bonding, and wettability was conducted using scanning electron microscopy, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, attenuated total reflectance Fourier transform infrared spectroscopy, and contact angle measurement. From the results, biomineralization of both coated and noncoated composite membranes was observed on the surface of nanofibers after 21 days in SBF. The membranes provide a superhydrophilic surface as shown by the contact angle. In conclusion, this biomimetic electrospun composite membrane could be used to further support cell growth for bone tissue engineering application. SN - 1538-943X UR - https://www.unboundmedicine.com/medline/citation/28901994/Biomineralized_Conductive_PEDOT:_PSS_Coated_PLA/PHBV/HA_Nanofibrous_Membranes_ L2 - http://dx.doi.org/10.1097/MAT.0000000000000655 DB - PRIME DP - Unbound Medicine ER -