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Chronic kidney disease and metabolic syndrome as risk factors for cardiovascular disease in a primary care program.
J Bras Nefrol. 2017 Jul-Sep; 39(3):246-252.JB

Abstract

INTRODUCTION

Cardiovascular disease (CVD) is especially prevalent in patients with chronic kidney disease (CKD).

OBJECTIVE

To evaluate the role of CKD and metabolic syndrome (MS), which is a cluster of risk factors for CVD, as predictors of CVD.

METHODS

Observational, cross-sectional study with a random sample aged 45 or more years extracted from the population assisted by the primary care program in Niterói city in the state of Rio de Janeiro, Brazil. CKD was diagnosed by the K/DOQI guidelines and MS, by the harmonized criteria. CVD was said to be present if the participant had one or more of the following findings: echocardiographic abnormalities, and history of myocardial infarction, stroke or heart failure. A logistic regression model was developed to analyze risk factors for CVD using CKD as the variable of primary interest.

RESULTS

Fifty hundred and eighty-one participants (38.2% male) with a mean age of 59.4 ± 10.2 years were analyzed. The prevalence rate of CKD was 27.9%. In participants without CKD, MS was associated with a slight but statistically significant increase in the risk for CVD (OR = 1.52, p = 0.037); in those with CKD but without MS the risk for CVD was also statistically significant and at a greater magnitude (OR = 2.42, p = 0.003); when both were present the risk for CVD was substantially higher (OR = 5.13, p < 0.001).

CONCLUSION

In this study involving a population assisted by a primary care program, CKD was confirmed as an independent risk factor for CVD. The presence of MS concurrent with CKD substantially amplified the risk for CVD.

Authors+Show Affiliations

Universidade Federal Fluminense.Universidade Federal Fluminense.Universidade Federal Fluminense.Universidade Federal Fluminense.Universidade Federal Fluminense.Universidade Federal Fluminense.Universidade Federal Fluminense.

Pub Type(s)

Journal Article
Observational Study

Language

eng por

PubMed ID

28902230

Citation

Greffin, Suzana, et al. "Chronic Kidney Disease and Metabolic Syndrome as Risk Factors for Cardiovascular Disease in a Primary Care Program." Jornal Brasileiro De Nefrologia : 'orgao Oficial De Sociedades Brasileira E Latino-Americana De Nefrologia, vol. 39, no. 3, 2017, pp. 246-252.
Greffin S, André MB, Matos JPS, et al. Chronic kidney disease and metabolic syndrome as risk factors for cardiovascular disease in a primary care program. J Bras Nefrol. 2017;39(3):246-252.
Greffin, S., André, M. B., Matos, J. P. S., Kang, H. C., Jorge, A. J. L., Rosa, M. L. G., & Lugon, J. R. (2017). Chronic kidney disease and metabolic syndrome as risk factors for cardiovascular disease in a primary care program. Jornal Brasileiro De Nefrologia : 'orgao Oficial De Sociedades Brasileira E Latino-Americana De Nefrologia, 39(3), 246-252. https://doi.org/10.5935/0101-2800.20170040
Greffin S, et al. Chronic Kidney Disease and Metabolic Syndrome as Risk Factors for Cardiovascular Disease in a Primary Care Program. J Bras Nefrol. 2017 Jul-Sep;39(3):246-252. PubMed PMID: 28902230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic kidney disease and metabolic syndrome as risk factors for cardiovascular disease in a primary care program. AU - Greffin,Suzana, AU - André,Mauro Barros, AU - Matos,Jorge Paulo Strogoff de, AU - Kang,Hye Chung, AU - Jorge,Antonio José Lagoeiro, AU - Rosa,Maria Luiza Garcia, AU - Lugon,Jocemir Ronaldo, Y1 - 2017/08/28/ PY - 2016/09/30/received PY - 2016/11/04/accepted PY - 2017/9/14/pubmed PY - 2018/7/20/medline PY - 2017/9/14/entrez SP - 246 EP - 252 JF - Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia JO - J Bras Nefrol VL - 39 IS - 3 N2 - INTRODUCTION: Cardiovascular disease (CVD) is especially prevalent in patients with chronic kidney disease (CKD). OBJECTIVE: To evaluate the role of CKD and metabolic syndrome (MS), which is a cluster of risk factors for CVD, as predictors of CVD. METHODS: Observational, cross-sectional study with a random sample aged 45 or more years extracted from the population assisted by the primary care program in Niterói city in the state of Rio de Janeiro, Brazil. CKD was diagnosed by the K/DOQI guidelines and MS, by the harmonized criteria. CVD was said to be present if the participant had one or more of the following findings: echocardiographic abnormalities, and history of myocardial infarction, stroke or heart failure. A logistic regression model was developed to analyze risk factors for CVD using CKD as the variable of primary interest. RESULTS: Fifty hundred and eighty-one participants (38.2% male) with a mean age of 59.4 ± 10.2 years were analyzed. The prevalence rate of CKD was 27.9%. In participants without CKD, MS was associated with a slight but statistically significant increase in the risk for CVD (OR = 1.52, p = 0.037); in those with CKD but without MS the risk for CVD was also statistically significant and at a greater magnitude (OR = 2.42, p = 0.003); when both were present the risk for CVD was substantially higher (OR = 5.13, p < 0.001). CONCLUSION: In this study involving a population assisted by a primary care program, CKD was confirmed as an independent risk factor for CVD. The presence of MS concurrent with CKD substantially amplified the risk for CVD. SN - 2175-8239 UR - https://www.unboundmedicine.com/medline/citation/28902230/Chronic_kidney_disease_and_metabolic_syndrome_as_risk_factors_for_cardiovascular_disease_in_a_primary_care_program_ L2 - https://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0101-28002017001303101&amp;lng=en&amp;nrm=iso&amp;tlng=en DB - PRIME DP - Unbound Medicine ER -