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A case of reversible anti-NMDA-receptor encephalitis: neuropsychological and neuroradiological features.
Neurol Sci. 2017 Dec; 38(12):2231-2236.NS

Abstract

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune encephalitis mainly affecting young women. We report a case of a mild paraneoplastic anti-NMDAR encephalitis in a 31-year-old female with an ovarian immature teratoma. The patient exhibited a severe short-term episodic memory impairment and psychiatric symptoms. A detailed diagnostic work-up including complete clinical and laboratory examinations, neuropsychological assessments, and neuroradiological investigations has been done at the onset and during follow-up. The amnestic syndrome and MRI medial-temporal abnormalities reversed after medical and surgical treatment. The present report indicates that the disease can be rapidly reversible if promptly diagnosed and treated. While the disease has already been described elsewhere, the course of neurospychological deficits in adults is not as much known. Usually, when the diagnosis of anti-NMDAR encephalitis is made, the severity of the disease makes the assessment of the neuropsycological profile particulary challenging. The present report is of interest because it describes the complete neuropsychological profile of a mild form of anti-NMDAR encephalitis.

Authors+Show Affiliations

Department of Medicine and Surgery, Section of Neurology, University of Parma, Via Gramsci 14, 43126, Parma (PR), Italy.Alzheimer Center, Briolini Hospital, Gazzaniga, Bergamo, Italy.Department of Emergency care, General and Specialist Medical Area, AOU, Parma, Italy.Department of Emergency care, General and Specialist Medical Area, AOU, Parma, Italy.Department of Emergency, Neurology Unit, Piacenza, Italy.Department of Medicine and Surgery, Section of Neurology, University of Parma, Via Gramsci 14, 43126, Parma (PR), Italy.Gruppo sostegno Alzheimer, Fidenza, Parma, Italy.Department of Medicine and Surgery, Section of Neurology, University of Parma, Via Gramsci 14, 43126, Parma (PR), Italy. paolo.caffarra@unipr.it.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28905135

Citation

Mutti, Carlotta, et al. "A Case of Reversible anti-NMDA-receptor Encephalitis: Neuropsychological and Neuroradiological Features." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 38, no. 12, 2017, pp. 2231-2236.
Mutti C, Barocco F, Zinno L, et al. A case of reversible anti-NMDA-receptor encephalitis: neuropsychological and neuroradiological features. Neurol Sci. 2017;38(12):2231-2236.
Mutti, C., Barocco, F., Zinno, L., Negrotti, A., Spallazzi, M., Pavesi, G., Gardini, S., & Caffarra, P. (2017). A case of reversible anti-NMDA-receptor encephalitis: neuropsychological and neuroradiological features. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 38(12), 2231-2236. https://doi.org/10.1007/s10072-017-3105-4
Mutti C, et al. A Case of Reversible anti-NMDA-receptor Encephalitis: Neuropsychological and Neuroradiological Features. Neurol Sci. 2017;38(12):2231-2236. PubMed PMID: 28905135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of reversible anti-NMDA-receptor encephalitis: neuropsychological and neuroradiological features. AU - Mutti,Carlotta, AU - Barocco,Federica, AU - Zinno,Lucia, AU - Negrotti,Anna, AU - Spallazzi,Marco, AU - Pavesi,Giovanni, AU - Gardini,Simona, AU - Caffarra,Paolo, Y1 - 2017/09/13/ PY - 2017/05/04/received PY - 2017/08/30/accepted PY - 2017/9/15/pubmed PY - 2018/8/8/medline PY - 2017/9/15/entrez KW - Amnestic syndrome KW - Anti-NMDA-receptor KW - Encephalitis KW - Hippocampus KW - Ovarian teratoma SP - 2231 EP - 2236 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 38 IS - 12 N2 - Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune encephalitis mainly affecting young women. We report a case of a mild paraneoplastic anti-NMDAR encephalitis in a 31-year-old female with an ovarian immature teratoma. The patient exhibited a severe short-term episodic memory impairment and psychiatric symptoms. A detailed diagnostic work-up including complete clinical and laboratory examinations, neuropsychological assessments, and neuroradiological investigations has been done at the onset and during follow-up. The amnestic syndrome and MRI medial-temporal abnormalities reversed after medical and surgical treatment. The present report indicates that the disease can be rapidly reversible if promptly diagnosed and treated. While the disease has already been described elsewhere, the course of neurospychological deficits in adults is not as much known. Usually, when the diagnosis of anti-NMDAR encephalitis is made, the severity of the disease makes the assessment of the neuropsycological profile particulary challenging. The present report is of interest because it describes the complete neuropsychological profile of a mild form of anti-NMDAR encephalitis. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/28905135/A_case_of_reversible_anti_NMDA_receptor_encephalitis:_neuropsychological_and_neuroradiological_features_ L2 - https://link.springer.com/10.1007/s10072-017-3105-4 DB - PRIME DP - Unbound Medicine ER -