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Pilot Study to Assess the Efficacy of Ivermectin and Fenbendazole for Treating Captive-Born Olive Baboons (Papio anubis) Coinfected with Strongyloides fülleborni and Trichuris trichiura.
J Am Assoc Lab Anim Sci. 2017 Jan 01; 56(1):52-56.JA

Abstract

In this study, we evaluated the efficacy of combined treatment with ivermectin and fenbendazole (IVM-FBZ) for treating captive olive baboons (Papio anubis) infected with Strongyloides fülleborni and Trichuris trichiura, 2 common nematode parasites of these NHP. Infected baboons were treated for a total of 9 wk with ivermectin (400 μg/kg IM twice weekly) and fenbendazole (50 mg/kg PO once daily for 3 d; 3 rounds of treatment, 21 d apart). Five baboons naturally infected with both S. fülleborni and T. trichiura (n = 4) or S. fülleborni alone (n = 1) received the combination therapy; an additional baboon infected with both parasites served as a nontreated control. The efficacy of IVM-FBZ was measured as the reduction in fecal egg counts of S. fülleborni and T. trichiura as determined by quantitative fecal flotation examination after treatment of baboons with IVM-FBZ. All baboons treated with IVM-FBZ stopped shedding S. fülleborni and T. trichiura eggs by 8 d after treatment and remained negative for at least 161 d. The nontreated control baboon shed S. fülleborni and T. trichiura eggs throughout the study period. Our results indicate that the IVM-FBZ regimen was efficacious for treating olive baboons infected with S. fülleborni and T. trichiura.

Authors+Show Affiliations

Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma, USA. mason.reichard@okstate.edu.Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma, USA.Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma, USA.Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma, USA.Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28905715

Citation

Reichard, Mason V., et al. "Pilot Study to Assess the Efficacy of Ivermectin and Fenbendazole for Treating Captive-Born Olive Baboons (Papio Anubis) Coinfected With Strongyloides Fülleborni and Trichuris Trichiura." Journal of the American Association for Laboratory Animal Science : JAALAS, vol. 56, no. 1, 2017, pp. 52-56.
Reichard MV, Thomas JE, Chavez-Suarez M, et al. Pilot Study to Assess the Efficacy of Ivermectin and Fenbendazole for Treating Captive-Born Olive Baboons (Papio anubis) Coinfected with Strongyloides fülleborni and Trichuris trichiura. J Am Assoc Lab Anim Sci. 2017;56(1):52-56.
Reichard, M. V., Thomas, J. E., Chavez-Suarez, M., Cullin, C. O., White, G. L., Wydysh, E. C., & Wolf, R. F. (2017). Pilot Study to Assess the Efficacy of Ivermectin and Fenbendazole for Treating Captive-Born Olive Baboons (Papio anubis) Coinfected with Strongyloides fülleborni and Trichuris trichiura. Journal of the American Association for Laboratory Animal Science : JAALAS, 56(1), 52-56.
Reichard MV, et al. Pilot Study to Assess the Efficacy of Ivermectin and Fenbendazole for Treating Captive-Born Olive Baboons (Papio Anubis) Coinfected With Strongyloides Fülleborni and Trichuris Trichiura. J Am Assoc Lab Anim Sci. 2017 Jan 1;56(1):52-56. PubMed PMID: 28905715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pilot Study to Assess the Efficacy of Ivermectin and Fenbendazole for Treating Captive-Born Olive Baboons (Papio anubis) Coinfected with Strongyloides fülleborni and Trichuris trichiura. AU - Reichard,Mason V, AU - Thomas,Jennifer E, AU - Chavez-Suarez,Maria, AU - Cullin,Cassandra O, AU - White,Gary L, AU - Wydysh,Emily C, AU - Wolf,Roman F, PY - 2017/9/15/entrez PY - 2017/9/15/pubmed PY - 2018/3/20/medline SP - 52 EP - 56 JF - Journal of the American Association for Laboratory Animal Science : JAALAS JO - J Am Assoc Lab Anim Sci VL - 56 IS - 1 N2 - In this study, we evaluated the efficacy of combined treatment with ivermectin and fenbendazole (IVM-FBZ) for treating captive olive baboons (Papio anubis) infected with Strongyloides fülleborni and Trichuris trichiura, 2 common nematode parasites of these NHP. Infected baboons were treated for a total of 9 wk with ivermectin (400 μg/kg IM twice weekly) and fenbendazole (50 mg/kg PO once daily for 3 d; 3 rounds of treatment, 21 d apart). Five baboons naturally infected with both S. fülleborni and T. trichiura (n = 4) or S. fülleborni alone (n = 1) received the combination therapy; an additional baboon infected with both parasites served as a nontreated control. The efficacy of IVM-FBZ was measured as the reduction in fecal egg counts of S. fülleborni and T. trichiura as determined by quantitative fecal flotation examination after treatment of baboons with IVM-FBZ. All baboons treated with IVM-FBZ stopped shedding S. fülleborni and T. trichiura eggs by 8 d after treatment and remained negative for at least 161 d. The nontreated control baboon shed S. fülleborni and T. trichiura eggs throughout the study period. Our results indicate that the IVM-FBZ regimen was efficacious for treating olive baboons infected with S. fülleborni and T. trichiura. SN - 1559-6109 UR - https://www.unboundmedicine.com/medline/citation/28905715/Pilot_Study_to_Assess_the_Efficacy_of_Ivermectin_and_Fenbendazole_for_Treating_Captive_Born_Olive_Baboons__Papio_anubis__Coinfected_with_Strongyloides_fülleborni_and_Trichuris_trichiura_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1559-6109&volume=56&issue=1&spage=52&aulast=Reichard DB - PRIME DP - Unbound Medicine ER -