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Latest Insights on Food Protein-Induced Enterocolitis Syndrome: An Emerging Medical Condition.

Abstract

Food protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food hypersensitivity characterized by profuse vomiting that is frequently associated with pallor or/and lethargy and appears within 1 to 3 hours after ingestion of the offending food. A less frequent chronic form of FPIES is characterized by protracted vomiting, diarrhea, or both accompanied by poor growth. Although FPIES is considered a rare allergic disorder, increasing reports in recent years point to a real increase in incidence, or at least an increased awareness of this condition by pediatricians. The foods most frequently implicated are cow's milk, soy formula, grains, and fish, depending on the geographic area. Diagnosis is based on clinical manifestations and requires a high index of suspicion, since we still lack a diagnostic laboratory tool. Early recognition of FPIES and removal of the offending food are mandatory. International consensus guidelines on diagnosis and management have been published. Prognosis is usually good, with most children tolerating foods before 6 years of age.

Authors+Show Affiliations

Pediatric Allergy Department, Children's Hospital Teresa Herrera, La Coruña, Spain.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28906253

Citation

Vila Sexto, L. "Latest Insights On Food Protein-Induced Enterocolitis Syndrome: an Emerging Medical Condition." Journal of Investigational Allergology & Clinical Immunology, vol. 28, no. 1, 2018, pp. 13-23.
Vila Sexto L. Latest Insights on Food Protein-Induced Enterocolitis Syndrome: An Emerging Medical Condition. J Investig Allergol Clin Immunol. 2018;28(1):13-23.
Vila Sexto, L. (2018). Latest Insights on Food Protein-Induced Enterocolitis Syndrome: An Emerging Medical Condition. Journal of Investigational Allergology & Clinical Immunology, 28(1), pp. 13-23. doi:10.18176/jiaci.0192.
Vila Sexto L. Latest Insights On Food Protein-Induced Enterocolitis Syndrome: an Emerging Medical Condition. J Investig Allergol Clin Immunol. 2018;28(1):13-23. PubMed PMID: 28906253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Latest Insights on Food Protein-Induced Enterocolitis Syndrome: An Emerging Medical Condition. A1 - Vila Sexto,L, Y1 - 2017/08/29/ PY - 2017/9/15/pubmed PY - 2019/9/5/medline PY - 2017/9/15/entrez KW - Cow’s milk KW - FPIES KW - Fish KW - Food allergy KW - Food-induced enterocolitis KW - Ondansetron KW - Oral food challenge SP - 13 EP - 23 JF - Journal of investigational allergology & clinical immunology JO - J Investig Allergol Clin Immunol VL - 28 IS - 1 N2 - Food protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food hypersensitivity characterized by profuse vomiting that is frequently associated with pallor or/and lethargy and appears within 1 to 3 hours after ingestion of the offending food. A less frequent chronic form of FPIES is characterized by protracted vomiting, diarrhea, or both accompanied by poor growth. Although FPIES is considered a rare allergic disorder, increasing reports in recent years point to a real increase in incidence, or at least an increased awareness of this condition by pediatricians. The foods most frequently implicated are cow's milk, soy formula, grains, and fish, depending on the geographic area. Diagnosis is based on clinical manifestations and requires a high index of suspicion, since we still lack a diagnostic laboratory tool. Early recognition of FPIES and removal of the offending food are mandatory. International consensus guidelines on diagnosis and management have been published. Prognosis is usually good, with most children tolerating foods before 6 years of age. SN - 1018-9068 UR - https://www.unboundmedicine.com/medline/citation/28906253/Latest_Insights_on_Food_Protein_Induced_Enterocolitis_Syndrome:_An_Emerging_Medical_Condition_ L2 - http://www.jiaci.org/summary/vol28-issue1-num1566 DB - PRIME DP - Unbound Medicine ER -