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Oxidative Damage and Genetic Toxicity Induced by DBP in Earthworms (Eisenia fetida).
Arch Environ Contam Toxicol. 2018 May; 74(4):527-538.AE

Abstract

Di-n-butyl phthalate (DBP) is one of the most ubiquitous plasticizers used worldwide. However, it has negatives effects on the soil, water, atmosphere, and other environmental media and can cause serious pollution. According to the artificial soil test and previous studies, this study was conducted to evaluate the toxicity of earthworms induced by DBP at different concentrations (0, 0.1, 1.0, 10, and 50 mg kg-1) on the 7th, 14th, 21st, and 28th days of exposure. The variations in the antioxidant activities of enzymes, such as catalase (CAT), peroxidase (POD), superoxide dismutase (SOD), and glutathione-S-transferase (GST), in the amounts of malondialdehyde (MDA) and reactive oxygen species (ROS) and in the amount of DNA damage were measured to evaluate the toxic impact of DBP in earthworms. Upon exposure to DBP, the SOD, CAT, POD, and GST activities were significantly increased, with the exception of the 0.1 mg kg-1 treatment dose. High concentrations of DBP (10 and 50 mg kg-1) induced superfluous ROS to be produced and caused the MDA content to increase significantly. Therefore, we proposed that DBP led to DNA damage in earthworm coelomocytes in a dose-dependent manner, which means that DBP is a source of oxidative damage and genetic toxicity in earthworms.

Authors+Show Affiliations

College of Resources and Environment, Key Laboratory of Agricultural Environment, Shandong Agricultural University, Tai'an, 271018, China. College of Water Sciences, Beijing Normal University, Beijing, 100875, China. Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.College of Resources and Environment, Key Laboratory of Agricultural Environment, Shandong Agricultural University, Tai'an, 271018, China. jwang@sdau.edu.cn.College of Resources and Environment, Key Laboratory of Agricultural Environment, Shandong Agricultural University, Tai'an, 271018, China.College of Resources and Environment, Key Laboratory of Agricultural Environment, Shandong Agricultural University, Tai'an, 271018, China.College of Resources and Environment, Key Laboratory of Agricultural Environment, Shandong Agricultural University, Tai'an, 271018, China.Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.College of Resources and Environment, Key Laboratory of Agricultural Environment, Shandong Agricultural University, Tai'an, 271018, China.College of Resources and Environment, Key Laboratory of Agricultural Environment, Shandong Agricultural University, Tai'an, 271018, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28913550

Citation

Wang, Guanying, et al. "Oxidative Damage and Genetic Toxicity Induced By DBP in Earthworms (Eisenia Fetida)." Archives of Environmental Contamination and Toxicology, vol. 74, no. 4, 2018, pp. 527-538.
Wang G, Wang J, Zhu L, et al. Oxidative Damage and Genetic Toxicity Induced by DBP in Earthworms (Eisenia fetida). Arch Environ Contam Toxicol. 2018;74(4):527-538.
Wang, G., Wang, J., Zhu, L., Wang, J., Li, H., Zhang, Y., Liu, W., & Gao, J. (2018). Oxidative Damage and Genetic Toxicity Induced by DBP in Earthworms (Eisenia fetida). Archives of Environmental Contamination and Toxicology, 74(4), 527-538. https://doi.org/10.1007/s00244-017-0451-4
Wang G, et al. Oxidative Damage and Genetic Toxicity Induced By DBP in Earthworms (Eisenia Fetida). Arch Environ Contam Toxicol. 2018;74(4):527-538. PubMed PMID: 28913550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative Damage and Genetic Toxicity Induced by DBP in Earthworms (Eisenia fetida). AU - Wang,Guanying, AU - Wang,Jun, AU - Zhu,Lusheng, AU - Wang,Jinhua, AU - Li,Hengzhou, AU - Zhang,Yizhang, AU - Liu,Wenjun, AU - Gao,Jianpeng, Y1 - 2017/09/14/ PY - 2017/03/04/received PY - 2017/09/06/accepted PY - 2017/9/16/pubmed PY - 2018/6/5/medline PY - 2017/9/16/entrez SP - 527 EP - 538 JF - Archives of environmental contamination and toxicology JO - Arch Environ Contam Toxicol VL - 74 IS - 4 N2 - Di-n-butyl phthalate (DBP) is one of the most ubiquitous plasticizers used worldwide. However, it has negatives effects on the soil, water, atmosphere, and other environmental media and can cause serious pollution. According to the artificial soil test and previous studies, this study was conducted to evaluate the toxicity of earthworms induced by DBP at different concentrations (0, 0.1, 1.0, 10, and 50 mg kg-1) on the 7th, 14th, 21st, and 28th days of exposure. The variations in the antioxidant activities of enzymes, such as catalase (CAT), peroxidase (POD), superoxide dismutase (SOD), and glutathione-S-transferase (GST), in the amounts of malondialdehyde (MDA) and reactive oxygen species (ROS) and in the amount of DNA damage were measured to evaluate the toxic impact of DBP in earthworms. Upon exposure to DBP, the SOD, CAT, POD, and GST activities were significantly increased, with the exception of the 0.1 mg kg-1 treatment dose. High concentrations of DBP (10 and 50 mg kg-1) induced superfluous ROS to be produced and caused the MDA content to increase significantly. Therefore, we proposed that DBP led to DNA damage in earthworm coelomocytes in a dose-dependent manner, which means that DBP is a source of oxidative damage and genetic toxicity in earthworms. SN - 1432-0703 UR - https://www.unboundmedicine.com/medline/citation/28913550/Oxidative_Damage_and_Genetic_Toxicity_Induced_by_DBP_in_Earthworms__Eisenia_fetida__ L2 - https://dx.doi.org/10.1007/s00244-017-0451-4 DB - PRIME DP - Unbound Medicine ER -