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[Effect of hyperforin on learning and memory abilities and Aβ₁₋₄₂, βAPP and BACE1 protein expressions in hippocampus of Alzheimer's disease model mice].
Zhongguo Zhong Yao Za Zhi. 2016 Aug; 41(15):2877-2882.ZZ

Abstract

To investigate the effect of the hyperforin (HF) on learning and memory function and Aβ₁₋₄₂, βAPP and BACE1 protein expressions in hippocampus of five-month-old APP/PS1 double transgenic mice, and discuss the underlying mechanism of HF. The five-month-old APP/PS1 double transgenic mice were randomly divided into the model group, rosiglitazone group (12 mg•kg⁻¹•d⁻¹) and HF high dose, middle dose and low dose groups (600, 300 and 150 mg•kg⁻¹•d⁻¹) in each group; in addition, 15C57BL/6J mice with the same months and background were selected as normal group. Drugs were diluted in the same volume before using, and then administrated by ig for 7 months, 1 time a day; the mice in normal group and model group received the same volume of distilled water. The learning and memory ability was tested by Morris water maze; Aβ₁₋₄₂, βAPP and BACE1proteinexpressionlevelswere tested by immunohistochemistry and Western blot. The Morris water maze results showed that as compared with the normal group, the learning and memory ability was significantly impaired in mice of model group (P<0.01); as compared with the model group, the learning and memory ability was improved in mice of rosiglitazone group and HF high, middle and low dose groups(P<0.01 or P<0.05). Immunohistochemistry and western blot results showed thatas compared with the normal group, the Aβ₁₋₄₂, βAPP and BACE1 protein expression levels in hippocampus were significantly increased in mice of model group (P<0.01);as compared with the model group, Aβ₁₋₄₂, βAPP and BACE1 protein expression levels in hippocampus were decreased in mice of rosiglitazone group and HF high, middle and low dose groups (P<0.01 or P<0.05). HF may improve the learning and memory ability of AD model mice via inhibition of βAPP and BACE1 protein expressions, thus reduced the generation of Aβ₁₋₄₂ proteins and amyloid plaque deposits in the brain.

Authors+Show Affiliations

Department of Pharmacy, Huaihe Hospital of Henan University, Kaifeng 475000, China.College of Pharmacy, Henan University, Kaifeng 475000, China.The First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

28914032

Citation

Geng, Yan-Na, et al. "[Effect of Hyperforin On Learning and Memory Abilities and Aβ₁₋₄₂, βAPP and BACE1 Protein Expressions in Hippocampus of Alzheimer's Disease Model Mice]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 41, no. 15, 2016, pp. 2877-2882.
Geng YN, Wu YJ, Zhang WX. [Effect of hyperforin on learning and memory abilities and Aβ₁₋₄₂, βAPP and BACE1 protein expressions in hippocampus of Alzheimer's disease model mice]. Zhongguo Zhong Yao Za Zhi. 2016;41(15):2877-2882.
Geng, Y. N., Wu, Y. J., & Zhang, W. X. (2016). [Effect of hyperforin on learning and memory abilities and Aβ₁₋₄₂, βAPP and BACE1 protein expressions in hippocampus of Alzheimer's disease model mice]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 41(15), 2877-2882. https://doi.org/10.4268/cjcmm20161522
Geng YN, Wu YJ, Zhang WX. [Effect of Hyperforin On Learning and Memory Abilities and Aβ₁₋₄₂, βAPP and BACE1 Protein Expressions in Hippocampus of Alzheimer's Disease Model Mice]. Zhongguo Zhong Yao Za Zhi. 2016;41(15):2877-2882. PubMed PMID: 28914032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of hyperforin on learning and memory abilities and Aβ₁₋₄₂, βAPP and BACE1 protein expressions in hippocampus of Alzheimer's disease model mice]. AU - Geng,Yan-Na, AU - Wu,Yi-Jun, AU - Zhang,Wen-Xin, PY - 2016/04/28/received PY - 2017/9/16/entrez PY - 2017/9/16/pubmed PY - 2018/5/23/medline KW - APP/PS1 double transgenic KW - Aβ₁₋₄₂ KW - BACE1 KW - Morris water maze KW - hyperforin SP - 2877 EP - 2882 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 41 IS - 15 N2 - To investigate the effect of the hyperforin (HF) on learning and memory function and Aβ₁₋₄₂, βAPP and BACE1 protein expressions in hippocampus of five-month-old APP/PS1 double transgenic mice, and discuss the underlying mechanism of HF. The five-month-old APP/PS1 double transgenic mice were randomly divided into the model group, rosiglitazone group (12 mg•kg⁻¹•d⁻¹) and HF high dose, middle dose and low dose groups (600, 300 and 150 mg•kg⁻¹•d⁻¹) in each group; in addition, 15C57BL/6J mice with the same months and background were selected as normal group. Drugs were diluted in the same volume before using, and then administrated by ig for 7 months, 1 time a day; the mice in normal group and model group received the same volume of distilled water. The learning and memory ability was tested by Morris water maze; Aβ₁₋₄₂, βAPP and BACE1proteinexpressionlevelswere tested by immunohistochemistry and Western blot. The Morris water maze results showed that as compared with the normal group, the learning and memory ability was significantly impaired in mice of model group (P<0.01); as compared with the model group, the learning and memory ability was improved in mice of rosiglitazone group and HF high, middle and low dose groups(P<0.01 or P<0.05). Immunohistochemistry and western blot results showed thatas compared with the normal group, the Aβ₁₋₄₂, βAPP and BACE1 protein expression levels in hippocampus were significantly increased in mice of model group (P<0.01);as compared with the model group, Aβ₁₋₄₂, βAPP and BACE1 protein expression levels in hippocampus were decreased in mice of rosiglitazone group and HF high, middle and low dose groups (P<0.01 or P<0.05). HF may improve the learning and memory ability of AD model mice via inhibition of βAPP and BACE1 protein expressions, thus reduced the generation of Aβ₁₋₄₂ proteins and amyloid plaque deposits in the brain. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/28914032/[Effect_of_hyperforin_on_learning_and_memory_abilities_and_Aβ₁₋₄₂_βAPP_and_BACE1_protein_expressions_in_hippocampus_of_Alzheimer's_disease_model_mice]_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -