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Phosphoinositide 5-phosphatase activities control cell motility in glioblastoma: Two phosphoinositides PI(4,5)P2 and PI(3,4)P2 are involved.
Adv Biol Regul 2018; 67:40-48AB

Abstract

Inositol polyphosphate 5-phosphatases or phosphoinositide 5-phosphatases (PI 5-phosphatases) are enzymes that can act on soluble inositol phosphates and/or phosphoinositides (PIs). Several PI 5-phosphatases have been linked to human genetic diseases, in particular the Lowe protein or OCRL which is mutated in the Lowe syndrome. There are 10 different members of this family and 9 of them can use PIs as substrate. One of these substrates, PI(3,4,5)P3 binds to specific PH domains and recruits as effectors specific proteins to signaling complexes. Protein kinase B is one target protein and activation of the kinase will have a major impact on cell proliferation, survival and cell metabolism. Two other PIs, PI(4,5)P2 and PI(3,4)P2, are produced or used as substrates of PI 5-phosphatases (OCRL, INPP5B, SHIP1/2, SYNJ1/2, INPP5K, INPP5J, INPP5E). The inositol lipids may influence many aspects of cytoskeletal organization, lamellipodia formation and F-actin polymerization. PI 5-phosphatases have been reported to control cell migration, adhesion, polarity and cell invasion particularly in cancer cells. In glioblastoma, reducing SHIP2 expression can positively or negatively affect the speed of cell migration depending on the glioblastoma cell type. The two PI 5-phosphatases SHIP2 or SKIP could be localized at the plasma membrane and can reduce either PI(3,4,5)P3 or PI(4,5)P2 abundance. In the glioblastoma 1321 N1 cells, SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration.

Authors+Show Affiliations

Interdisciplinary Research Institute (IRIBHM), Université Libre de Bruxelles, Campus Erasme, Bldg C, 808 Route de Lennik, 1070 Brussels, Belgium.Interdisciplinary Research Institute (IRIBHM), Université Libre de Bruxelles, Campus Erasme, Bldg C, 808 Route de Lennik, 1070 Brussels, Belgium.Interdisciplinary Research Institute (IRIBHM), Université Libre de Bruxelles, Campus Erasme, Bldg C, 808 Route de Lennik, 1070 Brussels, Belgium. Electronic address: cerneux@ulb.ac.be.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

28916189

Citation

Ramos, Ana Raquel, et al. "Phosphoinositide 5-phosphatase Activities Control Cell Motility in Glioblastoma: Two Phosphoinositides PI(4,5)P2 and PI(3,4)P2 Are Involved." Advances in Biological Regulation, vol. 67, 2018, pp. 40-48.
Ramos AR, Elong Edimo W, Erneux C. Phosphoinositide 5-phosphatase activities control cell motility in glioblastoma: Two phosphoinositides PI(4,5)P2 and PI(3,4)P2 are involved. Adv Biol Regul. 2018;67:40-48.
Ramos, A. R., Elong Edimo, W., & Erneux, C. (2018). Phosphoinositide 5-phosphatase activities control cell motility in glioblastoma: Two phosphoinositides PI(4,5)P2 and PI(3,4)P2 are involved. Advances in Biological Regulation, 67, pp. 40-48. doi:10.1016/j.jbior.2017.09.001.
Ramos AR, Elong Edimo W, Erneux C. Phosphoinositide 5-phosphatase Activities Control Cell Motility in Glioblastoma: Two Phosphoinositides PI(4,5)P2 and PI(3,4)P2 Are Involved. Adv Biol Regul. 2018;67:40-48. PubMed PMID: 28916189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phosphoinositide 5-phosphatase activities control cell motility in glioblastoma: Two phosphoinositides PI(4,5)P2 and PI(3,4)P2 are involved. AU - Ramos,Ana Raquel, AU - Elong Edimo,William's, AU - Erneux,Christophe, Y1 - 2017/09/05/ PY - 2017/08/25/received PY - 2017/09/01/revised PY - 2017/09/01/accepted PY - 2017/9/17/pubmed PY - 2019/9/13/medline PY - 2017/9/17/entrez KW - Cell migration KW - PI(4,5)P2 KW - Phosphoinositides KW - SHIP1/2 KW - Signal transduction SP - 40 EP - 48 JF - Advances in biological regulation JO - Adv Biol Regul VL - 67 N2 - Inositol polyphosphate 5-phosphatases or phosphoinositide 5-phosphatases (PI 5-phosphatases) are enzymes that can act on soluble inositol phosphates and/or phosphoinositides (PIs). Several PI 5-phosphatases have been linked to human genetic diseases, in particular the Lowe protein or OCRL which is mutated in the Lowe syndrome. There are 10 different members of this family and 9 of them can use PIs as substrate. One of these substrates, PI(3,4,5)P3 binds to specific PH domains and recruits as effectors specific proteins to signaling complexes. Protein kinase B is one target protein and activation of the kinase will have a major impact on cell proliferation, survival and cell metabolism. Two other PIs, PI(4,5)P2 and PI(3,4)P2, are produced or used as substrates of PI 5-phosphatases (OCRL, INPP5B, SHIP1/2, SYNJ1/2, INPP5K, INPP5J, INPP5E). The inositol lipids may influence many aspects of cytoskeletal organization, lamellipodia formation and F-actin polymerization. PI 5-phosphatases have been reported to control cell migration, adhesion, polarity and cell invasion particularly in cancer cells. In glioblastoma, reducing SHIP2 expression can positively or negatively affect the speed of cell migration depending on the glioblastoma cell type. The two PI 5-phosphatases SHIP2 or SKIP could be localized at the plasma membrane and can reduce either PI(3,4,5)P3 or PI(4,5)P2 abundance. In the glioblastoma 1321 N1 cells, SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration. SN - 2212-4934 UR - https://www.unboundmedicine.com/medline/citation/28916189/Phosphoinositide_5_phosphatase_activities_control_cell_motility_in_glioblastoma:_Two_phosphoinositides_PI_45_P2_and_PI_34_P2_are_involved_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2212-4926(17)30145-8 DB - PRIME DP - Unbound Medicine ER -