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Dietary intake of heme iron and body iron status are associated with the risk of gestational diabetes mellitus: a systematic review and meta-analysis.

Abstract

BACKGROUND AND OBJECTIVES

Some potential role of iron overload in the development of diabetes mellitus have been suggested. Our study aimed to systematically assess the association between the risk of gestational diabetes mellitus (GDM) and iron intakes/body iron status.

METHODS AND STUDY DESIGN

PubMed and Web of Science were searched for relevant articles. Relative risks (RR) of GDM in relation to dietary iron intakes and body iron stores were pooled with the random-effects model. Weighted mean differences of iron blood markers between GDM and non-GDM individuals were also analyzed.

RESULTS

Twenty-five studies were included in the qualitative analysis, and 23 studies with 29,378 participants and 3,034 GDM patients were included in the quantitative analysis. Dietary intake of heme iron was significantly associated with GDM risk (RR=1.65, 95% CI: 1.28 to 2.12), and the pooled RR for each 1mg/day increment of heme iron intake was 1.38 (95% CI: 1.19 to 1.61). No association between GDM and the intakes of nonheme iron, total iron, or supplemental iron was detected. Body iron stores, as represented by serum ferritin level, were correlated with GDM risk (RR=1.64, 95% CI: 1.27 to 2.11). Moreover, the concentrations of both serum ferritin and serum iron were increased in GDM patients, compared with non-GDM individuals.

CONCLUSIONS

Increased dietary intake of heme iron and body iron status are positively associated with the risk of GDM development in pregnant women. Future studies are warranted to better understand the role of iron in GDM development.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Nutrition Discovery Innovation Center, Institute of Nutrition and Food Safety, School of Public Health, School of Medicine, Zhejiang University, Zhejiang, China. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Zhejiang, China.

    ,

    Department of Nutrition, Nutrition Discovery Innovation Center, Institute of Nutrition and Food Safety, School of Public Health, School of Medicine, Zhejiang University, Zhejiang, China.

    ,

    DX Clinics, Zhejiang, China.

    ,

    Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, USA.

    ,

    Institute for Nutrition and Health, Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China.

    ,

    Department of Nutrition, Nutrition Discovery Innovation Center, Institute of Nutrition and Food Safety, School of Public Health, School of Medicine, Zhejiang University, Zhejiang, China.

    ,

    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Zhejiang, China. The first affiliated Hospital, Institute for Translational Medicine, Zhejiang University, Zhejiang, China.

    Department of Nutrition, Nutrition Discovery Innovation Center, Institute of Nutrition and Food Safety, School of Public Health, School of Medicine, Zhejiang University, Zhejiang, China. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Zhejiang, China. Institute for Nutrition and Health, Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China. Email: fwang@zju.edu.cn; fudiwang.lab@gmail.com.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28917236

    Citation

    Zhao, Lu, et al. "Dietary Intake of Heme Iron and Body Iron Status Are Associated With the Risk of Gestational Diabetes Mellitus: a Systematic Review and Meta-analysis." Asia Pacific Journal of Clinical Nutrition, vol. 26, no. 6, 2017, pp. 1092-1106.
    Zhao L, Lian J, Tian J, et al. Dietary intake of heme iron and body iron status are associated with the risk of gestational diabetes mellitus: a systematic review and meta-analysis. Asia Pac J Clin Nutr. 2017;26(6):1092-1106.
    Zhao, L., Lian, J., Tian, J., Shen, Y., Ping, Z., Fang, X., ... Wang, F. (2017). Dietary intake of heme iron and body iron status are associated with the risk of gestational diabetes mellitus: a systematic review and meta-analysis. Asia Pacific Journal of Clinical Nutrition, 26(6), pp. 1092-1106. doi:10.6133/apjcn.022017.09.
    Zhao L, et al. Dietary Intake of Heme Iron and Body Iron Status Are Associated With the Risk of Gestational Diabetes Mellitus: a Systematic Review and Meta-analysis. Asia Pac J Clin Nutr. 2017;26(6):1092-1106. PubMed PMID: 28917236.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intake of heme iron and body iron status are associated with the risk of gestational diabetes mellitus: a systematic review and meta-analysis. AU - Zhao,Lu, AU - Lian,Jia, AU - Tian,Jishun, AU - Shen,Ye, AU - Ping,Zhiguang, AU - Fang,Xuexian, AU - Min,Junxia, AU - Wang,Fudi, PY - 2017/9/18/entrez PY - 2017/9/18/pubmed PY - 2017/9/18/medline SP - 1092 EP - 1106 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 26 IS - 6 N2 - BACKGROUND AND OBJECTIVES: Some potential role of iron overload in the development of diabetes mellitus have been suggested. Our study aimed to systematically assess the association between the risk of gestational diabetes mellitus (GDM) and iron intakes/body iron status. METHODS AND STUDY DESIGN: PubMed and Web of Science were searched for relevant articles. Relative risks (RR) of GDM in relation to dietary iron intakes and body iron stores were pooled with the random-effects model. Weighted mean differences of iron blood markers between GDM and non-GDM individuals were also analyzed. RESULTS: Twenty-five studies were included in the qualitative analysis, and 23 studies with 29,378 participants and 3,034 GDM patients were included in the quantitative analysis. Dietary intake of heme iron was significantly associated with GDM risk (RR=1.65, 95% CI: 1.28 to 2.12), and the pooled RR for each 1mg/day increment of heme iron intake was 1.38 (95% CI: 1.19 to 1.61). No association between GDM and the intakes of nonheme iron, total iron, or supplemental iron was detected. Body iron stores, as represented by serum ferritin level, were correlated with GDM risk (RR=1.64, 95% CI: 1.27 to 2.11). Moreover, the concentrations of both serum ferritin and serum iron were increased in GDM patients, compared with non-GDM individuals. CONCLUSIONS: Increased dietary intake of heme iron and body iron status are positively associated with the risk of GDM development in pregnant women. Future studies are warranted to better understand the role of iron in GDM development. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/28917236/Dietary_intake_of_heme_iron_and_body_iron_status_are_associated_with_the_risk_of_gestational_diabetes_mellitus:_a_systematic_review_and_meta_analysis_ L2 - http://apjcn.nhri.org.tw/server/APJCN/26/6/1092.pdf DB - PRIME DP - Unbound Medicine ER -