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Neuroprotective effect of curcumin-I in copper-induced dopaminergic neurotoxicity in rats: A possible link with Parkinson's disease.
Neurosci Lett. 2017 Nov 01; 660:103-108.NL

Abstract

Numerous findings indicate an involvement of heavy metals in the neuropathology of several neurodegenerative disorders, especially Parkinson's disease (PD). Previous studies have demonstrated that Copper (Cu) exhibits a potent neurotoxic effect on dopaminergic neurons and triggers profound neurobehavioral alterations. Curcumin is a major component of Curcuma longa rhizomes and a powerful medicinal plant that exerts many pharmacological effects. However, the neuroprotective action of curcumin on Cu-induced dopaminergic neurotoxicity is yet to be investigated. The aim of the present study was to evaluate the impact of acute Cu-intoxication (10mg/kg B.W. i.p) for 3days on the dopaminergic system and locomotor performance as well as the possible therapeutic efficacy of curcumin I (30mg/kg B.W.). Intoxicated rats showed a significant loss of Tyrosine Hydroxylase (TH) expression within substantia nigra pars compacta (SNc), ventral tegmental area (VTA) and the striatal outputs. This was correlated with a clear decrease in locomotor performance. Critically, curcumin-I co-treatment reversed these changes and showed a noticeable protective effect; both TH expression and locomotor performance was reinstated in intoxicated rats. These results demonstrate altered dopaminergic innervations following Cu intoxication and a new therapeutic potential of curcumin against Cu-induced dopaminergic neurotransmission failure. Curcumin may therefore prevent heavy metal related Parkinsonism.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Abbaoui A
Cadi Ayyad University, faculty of sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Marrakesh, Morocco.
Chatoui H
Cadi Ayyad University, faculty of sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Marrakesh, Morocco.
El Hiba O
Cadi Ayyad University, faculty of sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Marrakesh, Morocco; Chouaib Doukkali University, Faculty of Sciences, Department of Biology, Morocco.
Gamrani H
Cadi Ayyad University, faculty of sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Marrakesh, Morocco. Electronic address: gamrani54@gmail.com.

MeSH

AnimalsBrainCopperCorpus StriatumCurcuminDopaminergic NeuronsLocomotionMaleNeuroprotective AgentsParkinson DiseasePars CompactaRats, WistarTyrosine 3-MonooxygenaseVentral Tegmental Area

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28919537

Citation

Abbaoui, Abdellatif, et al. "Neuroprotective Effect of curcumin-I in Copper-induced Dopaminergic Neurotoxicity in Rats: a Possible Link With Parkinson's Disease." Neuroscience Letters, vol. 660, 2017, pp. 103-108.
Abbaoui A, Chatoui H, El Hiba O, et al. Neuroprotective effect of curcumin-I in copper-induced dopaminergic neurotoxicity in rats: A possible link with Parkinson's disease. Neurosci Lett. 2017;660:103-108.
Abbaoui, A., Chatoui, H., El Hiba, O., & Gamrani, H. (2017). Neuroprotective effect of curcumin-I in copper-induced dopaminergic neurotoxicity in rats: A possible link with Parkinson's disease. Neuroscience Letters, 660, 103-108. https://doi.org/10.1016/j.neulet.2017.09.032
Abbaoui A, et al. Neuroprotective Effect of curcumin-I in Copper-induced Dopaminergic Neurotoxicity in Rats: a Possible Link With Parkinson's Disease. Neurosci Lett. 2017 Nov 1;660:103-108. PubMed PMID: 28919537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effect of curcumin-I in copper-induced dopaminergic neurotoxicity in rats: A possible link with Parkinson's disease. AU - Abbaoui,Abdellatif, AU - Chatoui,Hicham, AU - El Hiba,Omar, AU - Gamrani,Halima, Y1 - 2017/09/15/ PY - 2017/04/14/received PY - 2017/07/25/revised PY - 2017/09/14/accepted PY - 2017/9/19/pubmed PY - 2018/6/12/medline PY - 2017/9/19/entrez KW - Copper neurotoxicity KW - Curcumin KW - Dopamine KW - Locomotion KW - Midbrain KW - Wistar rat SP - 103 EP - 108 JF - Neuroscience letters JO - Neurosci Lett VL - 660 N2 - Numerous findings indicate an involvement of heavy metals in the neuropathology of several neurodegenerative disorders, especially Parkinson's disease (PD). Previous studies have demonstrated that Copper (Cu) exhibits a potent neurotoxic effect on dopaminergic neurons and triggers profound neurobehavioral alterations. Curcumin is a major component of Curcuma longa rhizomes and a powerful medicinal plant that exerts many pharmacological effects. However, the neuroprotective action of curcumin on Cu-induced dopaminergic neurotoxicity is yet to be investigated. The aim of the present study was to evaluate the impact of acute Cu-intoxication (10mg/kg B.W. i.p) for 3days on the dopaminergic system and locomotor performance as well as the possible therapeutic efficacy of curcumin I (30mg/kg B.W.). Intoxicated rats showed a significant loss of Tyrosine Hydroxylase (TH) expression within substantia nigra pars compacta (SNc), ventral tegmental area (VTA) and the striatal outputs. This was correlated with a clear decrease in locomotor performance. Critically, curcumin-I co-treatment reversed these changes and showed a noticeable protective effect; both TH expression and locomotor performance was reinstated in intoxicated rats. These results demonstrate altered dopaminergic innervations following Cu intoxication and a new therapeutic potential of curcumin against Cu-induced dopaminergic neurotransmission failure. Curcumin may therefore prevent heavy metal related Parkinsonism. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/28919537/Neuroprotective_effect_of_curcumin_I_in_copper_induced_dopaminergic_neurotoxicity_in_rats:_A_possible_link_with_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -