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Refinement of the Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians: detection of naturally occurring osteoarthritis in laboratory cats.
J Feline Med Surg 2018; 20(8):728-740JF

Abstract

Objectives Feline osteoarthritis causes pain and disability. Detection and measurement is challenging, relying heavily on owner report. This study describes refinement of the Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians. Methods A video analysis of osteoarthritic (n = 6) and non-osteoarthritic (n = 4) cats facilitated expansion of scale items. Three successive therapeutic trials (using gabapentin, tramadol and oral transmucosal meloxicam spray) in laboratory cats with and without natural osteoarthritis (n = 12-20) permitted construct validation (assessments of disease status sensitivity and therapeutic responsiveness) and further scale refinements based on performance. Results Scale osteoarthritic sensitivity improved from phase I to phase III; phase III scale total score (P = 0.0001) and 4/5 subcategories - body posture (P = 0.0006), gait (P = 0.0031), jumping (0.0824) and global distance examination (P = 0.0001) - detected osteoarthritic cats. Total score inter-rater (intra-class correlation coefficients [ICC] = 0.64-0.75), intra-rater (ICC = 0.90-0.91) and overall internal consistency (Cronbach's alpha = 0.85) reliability were good to excellent. von Frey anesthesiometer-induced paw withdrawal threshold increased with gabapentin in phase I, in osteoarthritic cats (P <0.001) but not in non-osteoarthritic cats (P = 0.075). Night-time activity increased during gabapentin treatment. Objective measures also detected tramadol and/or meloxicam treatment effects in osteoarthritic cats in phases II and III. There was some treatment responsiveness: in phase I, 3/10 subcategory scores improved (P <0.09) in treated osteoarthritic cats; in phase II, 3/8 subcategories improved; and in phase III, 1/5 subcategories improved (P <0.096). Conclusions and relevance The revised scale detected naturally occurring osteoarthritis, but not treatment effects, in laboratory cats, suggesting future potential for screening of at-risk cats. Further study is needed to confirm reliability, validity (disease sensitivity and treatment responsiveness) and clinical feasibility, as well as cut-off scores for osteoarthritic vs non-osteoarthritic status, in client-owned cats.

Authors+Show Affiliations

1 Animal Pharmacology Research Group of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences, Faculty of Veterinary Medicine - University of Montréal, Saint-Hyacinthe, QC, Canada. 2 Osteoarthritis Research Unit, Centre de Recherche du CHUM, Central Hospital of the University of Montréal, Montreal, QC, Canada.1 Animal Pharmacology Research Group of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences, Faculty of Veterinary Medicine - University of Montréal, Saint-Hyacinthe, QC, Canada.1 Animal Pharmacology Research Group of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences, Faculty of Veterinary Medicine - University of Montréal, Saint-Hyacinthe, QC, Canada. 2 Osteoarthritis Research Unit, Centre de Recherche du CHUM, Central Hospital of the University of Montréal, Montreal, QC, Canada.1 Animal Pharmacology Research Group of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences, Faculty of Veterinary Medicine - University of Montréal, Saint-Hyacinthe, QC, Canada. 2 Osteoarthritis Research Unit, Centre de Recherche du CHUM, Central Hospital of the University of Montréal, Montreal, QC, Canada.1 Animal Pharmacology Research Group of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences, Faculty of Veterinary Medicine - University of Montréal, Saint-Hyacinthe, QC, Canada. 2 Osteoarthritis Research Unit, Centre de Recherche du CHUM, Central Hospital of the University of Montréal, Montreal, QC, Canada.1 Animal Pharmacology Research Group of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences, Faculty of Veterinary Medicine - University of Montréal, Saint-Hyacinthe, QC, Canada.3 Department of Clinical Sciences, Faculty of Veterinary Medicine - University of Montréal, Saint-Hyacinthe, QC, Canada.3 Department of Clinical Sciences, Faculty of Veterinary Medicine - University of Montréal, Saint-Hyacinthe, QC, Canada.2 Osteoarthritis Research Unit, Centre de Recherche du CHUM, Central Hospital of the University of Montréal, Montreal, QC, Canada.2 Osteoarthritis Research Unit, Centre de Recherche du CHUM, Central Hospital of the University of Montréal, Montreal, QC, Canada.1 Animal Pharmacology Research Group of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences, Faculty of Veterinary Medicine - University of Montréal, Saint-Hyacinthe, QC, Canada.1 Animal Pharmacology Research Group of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences, Faculty of Veterinary Medicine - University of Montréal, Saint-Hyacinthe, QC, Canada. 2 Osteoarthritis Research Unit, Centre de Recherche du CHUM, Central Hospital of the University of Montréal, Montreal, QC, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28920533

Citation

Klinck, Mary P., et al. "Refinement of the Montreal Instrument for Cat Arthritis Testing, for Use By Veterinarians: Detection of Naturally Occurring Osteoarthritis in Laboratory Cats." Journal of Feline Medicine and Surgery, vol. 20, no. 8, 2018, pp. 728-740.
Klinck MP, Monteiro BP, Lussier B, et al. Refinement of the Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians: detection of naturally occurring osteoarthritis in laboratory cats. J Feline Med Surg. 2018;20(8):728-740.
Klinck, M. P., Monteiro, B. P., Lussier, B., Guillot, M., Moreau, M., Otis, C., ... Troncy, E. (2018). Refinement of the Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians: detection of naturally occurring osteoarthritis in laboratory cats. Journal of Feline Medicine and Surgery, 20(8), pp. 728-740. doi:10.1177/1098612X17730172.
Klinck MP, et al. Refinement of the Montreal Instrument for Cat Arthritis Testing, for Use By Veterinarians: Detection of Naturally Occurring Osteoarthritis in Laboratory Cats. J Feline Med Surg. 2018;20(8):728-740. PubMed PMID: 28920533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Refinement of the Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians: detection of naturally occurring osteoarthritis in laboratory cats. AU - Klinck,Mary P, AU - Monteiro,Beatriz P, AU - Lussier,Bertrand, AU - Guillot,Martin, AU - Moreau,Maxim, AU - Otis,Colombe, AU - Steagall,Paulo Vm, AU - Frank,Diane, AU - Martel-Pelletier,Johanne, AU - Pelletier,Jean-Pierre, AU - Del Castillo,Jérôme Re, AU - Troncy,Eric, Y1 - 2017/09/18/ PY - 2017/9/19/pubmed PY - 2019/9/10/medline PY - 2017/9/19/entrez SP - 728 EP - 740 JF - Journal of feline medicine and surgery JO - J. Feline Med. Surg. VL - 20 IS - 8 N2 - Objectives Feline osteoarthritis causes pain and disability. Detection and measurement is challenging, relying heavily on owner report. This study describes refinement of the Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians. Methods A video analysis of osteoarthritic (n = 6) and non-osteoarthritic (n = 4) cats facilitated expansion of scale items. Three successive therapeutic trials (using gabapentin, tramadol and oral transmucosal meloxicam spray) in laboratory cats with and without natural osteoarthritis (n = 12-20) permitted construct validation (assessments of disease status sensitivity and therapeutic responsiveness) and further scale refinements based on performance. Results Scale osteoarthritic sensitivity improved from phase I to phase III; phase III scale total score (P = 0.0001) and 4/5 subcategories - body posture (P = 0.0006), gait (P = 0.0031), jumping (0.0824) and global distance examination (P = 0.0001) - detected osteoarthritic cats. Total score inter-rater (intra-class correlation coefficients [ICC] = 0.64-0.75), intra-rater (ICC = 0.90-0.91) and overall internal consistency (Cronbach's alpha = 0.85) reliability were good to excellent. von Frey anesthesiometer-induced paw withdrawal threshold increased with gabapentin in phase I, in osteoarthritic cats (P <0.001) but not in non-osteoarthritic cats (P = 0.075). Night-time activity increased during gabapentin treatment. Objective measures also detected tramadol and/or meloxicam treatment effects in osteoarthritic cats in phases II and III. There was some treatment responsiveness: in phase I, 3/10 subcategory scores improved (P <0.09) in treated osteoarthritic cats; in phase II, 3/8 subcategories improved; and in phase III, 1/5 subcategories improved (P <0.096). Conclusions and relevance The revised scale detected naturally occurring osteoarthritis, but not treatment effects, in laboratory cats, suggesting future potential for screening of at-risk cats. Further study is needed to confirm reliability, validity (disease sensitivity and treatment responsiveness) and clinical feasibility, as well as cut-off scores for osteoarthritic vs non-osteoarthritic status, in client-owned cats. SN - 1532-2750 UR - https://www.unboundmedicine.com/medline/citation/28920533/Refinement_of_the_Montreal_Instrument_for_Cat_Arthritis_Testing_for_Use_by_Veterinarians:_detection_of_naturally_occurring_osteoarthritis_in_laboratory_cats_ L2 - http://journals.sagepub.com/doi/full/10.1177/1098612X17730172?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -