TY - JOUR T1 - The pathophysiology of arterial vasodilatation and hyperdynamic circulation in cirrhosis. AU - Møller,Søren, AU - Bendtsen,Flemming, Y1 - 2018/01/15/ PY - 2017/07/25/received PY - 2017/09/11/accepted PY - 2017/9/19/pubmed PY - 2019/1/8/medline PY - 2017/9/19/entrez KW - cardiac dysfunction KW - liver failure KW - multi-organ syndrome KW - portal hypertension SP - 570 EP - 580 JF - Liver international : official journal of the International Association for the Study of the Liver JO - Liver Int VL - 38 IS - 4 N2 - Patients with cirrhosis and portal hypertension often develop complications from a variety of organ systems leading to a multiple organ failure. The combination of liver failure and portal hypertension results in a hyperdynamic circulatory state partly owing to simultaneous splanchnic and peripheral arterial vasodilatation. Increases in circulatory vasodilators are believed to be due to portosystemic shunting and bacterial translocation leading to redistribution of the blood volume with central hypovolemia. Portal hypertension per se and increased splanchnic blood flow are mainly responsible for the development and perpetuation of the hyperdynamic circulation and the associated changes in cardiovascular function with development of cirrhotic cardiomyopathy, autonomic dysfunction and renal dysfunction as part of a cardiorenal syndrome. Several of the cardiovascular changes are reversible after liver transplantation and point to the pathophysiological significance of portal hypertension. In this paper, we aimed to review current knowledge on the pathophysiology of arterial vasodilatation and the hyperdynamic circulation in cirrhosis. SN - 1478-3231 UR - https://www.unboundmedicine.com/medline/citation/28921803/The_pathophysiology_of_arterial_vasodilatation_and_hyperdynamic_circulation_in_cirrhosis_ DB - PRIME DP - Unbound Medicine ER -