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Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) Syndrome with Significant Bilateral Pleural Effusions.
Intern Med 2017; 56(20):2779-2783IM

Abstract

We herein report a rare case of a 66-year-old woman who had synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome with marked sternal osteitis and bilateral pleural effusions. SAPHO syndrome was diagnosed based on the characteristic features of a hyperostotic sternum and thoracic spine. The inflammatory changes of sternal osteitis and involvement of the adjacent soft tissue were assumed to be the cause of the pleural effusions. The effusions decreased during the natural course of the disease and resolved after methotrexate therapy. The pain dramatically decreased with oral tramadol. Physicians should consider the possibility of SAPHO syndrome in patients with anterior chest pain and pleural effusions.

Authors+Show Affiliations

Division of Rheumatology, First Department of Comprehensive Medicine, Jichi Medical University Saitama Medical Center, Japan. Department of Orthopaedic Surgery, The Fraternity Memorial Hospital, Japan.Division of Rheumatology, First Department of Comprehensive Medicine, Jichi Medical University Saitama Medical Center, Japan.Division of Rheumatology, First Department of Comprehensive Medicine, Jichi Medical University Saitama Medical Center, Japan. Division of Hematology, National Hospital Organization Matsumoto Medical Center, Japan.Division of Rheumatology, First Department of Comprehensive Medicine, Jichi Medical University Saitama Medical Center, Japan.Division of Rheumatology, First Department of Comprehensive Medicine, Jichi Medical University Saitama Medical Center, Japan.Division of Rheumatology, First Department of Comprehensive Medicine, Jichi Medical University Saitama Medical Center, Japan.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28924111

Citation

Hasegawa, Shoichi, et al. "Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) Syndrome With Significant Bilateral Pleural Effusions." Internal Medicine (Tokyo, Japan), vol. 56, no. 20, 2017, pp. 2779-2783.
Hasegawa S, Yabe H, Kaneko N, et al. Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) Syndrome with Significant Bilateral Pleural Effusions. Intern Med. 2017;56(20):2779-2783.
Hasegawa, S., Yabe, H., Kaneko, N., Watanabe, E., Gono, T., & Terai, C. (2017). Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) Syndrome with Significant Bilateral Pleural Effusions. Internal Medicine (Tokyo, Japan), 56(20), pp. 2779-2783. doi:10.2169/internalmedicine.8250-16.
Hasegawa S, et al. Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) Syndrome With Significant Bilateral Pleural Effusions. Intern Med. 2017 Oct 15;56(20):2779-2783. PubMed PMID: 28924111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) Syndrome with Significant Bilateral Pleural Effusions. AU - Hasegawa,Shoichi, AU - Yabe,Hiroki, AU - Kaneko,Naoya, AU - Watanabe,Eri, AU - Gono,Takahisa, AU - Terai,Chihiro, Y1 - 2017/09/15/ PY - 2017/9/20/pubmed PY - 2018/4/12/medline PY - 2017/9/20/entrez KW - SAPHO syndrome KW - anterior chest wall KW - osteitis KW - pleural effusion KW - sternum SP - 2779 EP - 2783 JF - Internal medicine (Tokyo, Japan) JO - Intern. Med. VL - 56 IS - 20 N2 - We herein report a rare case of a 66-year-old woman who had synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome with marked sternal osteitis and bilateral pleural effusions. SAPHO syndrome was diagnosed based on the characteristic features of a hyperostotic sternum and thoracic spine. The inflammatory changes of sternal osteitis and involvement of the adjacent soft tissue were assumed to be the cause of the pleural effusions. The effusions decreased during the natural course of the disease and resolved after methotrexate therapy. The pain dramatically decreased with oral tramadol. Physicians should consider the possibility of SAPHO syndrome in patients with anterior chest pain and pleural effusions. SN - 1349-7235 UR - https://www.unboundmedicine.com/medline/citation/28924111/Synovitis_acne_pustulosis_hyperostosis_osteitis__SAPHO__Syndrome_with_Significant_Bilateral_Pleural_Effusions_ L2 - https://dx.doi.org/10.2169/internalmedicine.8250-16 DB - PRIME DP - Unbound Medicine ER -