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Plasma urocortin-1 as a preoperative marker of endometriosis in symptomatic women.
Gynecol Endocrinol. 2018 Mar; 34(3):202-205.GE

Abstract

Accurate noninvasive diagnostic tests for endometriosis are still missing. This study evaluated the predictive value of the neuropeptide urocortin 1 (Ucn1) to detect pelvic endometriosis in symptomatic women. We enrolled prospectively 97 consecutive women submitted to gynecologic laparoscopy for chronic or acute pelvic pain, infertility or adnexal mass. Preoperative blood samples were assayed for Ucn1 using enzyme immunoassay. Patients with endometriosis had higher plasma Ucn1 levels compared to patients with no lesions (median 59 vs. 34 pg/ml, p < .01, Dunn's test). Elevated plasma Ucn1 levels were found among all endometriosis phenotypes (superficial peritoneal lesions, ovarian endometrioma, and deep infiltrating endometriosis, p < .05 vs. no lesions). Receiver operating characteristics curve analysis identified plasma Ucn1 > 46 pg/mL as the best cutoff point to detect endometriosis vs. no lesions, with 76% sensitivity and 88% specificity (area under the curve [AUC] 0.827, 95% confidence interval [CI] 0.695 - 0.959), but no cutoff could accurately distinguish endometriosis from other pathological conditions (AUC 0.593 [95% CI 0.474 - 0.711]). In women with chronic pelvic pain, infertility, or both symptoms, the probability of endometriosis (positive predictive value) increased consistently with the increase of plasma Ucn1 levels. The present findings suggest that high plasma Ucn1 levels increase the likelihood of endometriosis in symptomatic women.

Authors+Show Affiliations

a Department of Obstetrics and Gynecology , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.a Department of Obstetrics and Gynecology , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.b Department of Pathology , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.c Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology , University of Florence, Careggi University Hospital , Florence , Italy.a Department of Obstetrics and Gynecology , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28925754

Citation

Maia, Laura M., et al. "Plasma Urocortin-1 as a Preoperative Marker of Endometriosis in Symptomatic Women." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 34, no. 3, 2018, pp. 202-205.
Maia LM, Rocha AL, Del Puerto HL, et al. Plasma urocortin-1 as a preoperative marker of endometriosis in symptomatic women. Gynecol Endocrinol. 2018;34(3):202-205.
Maia, L. M., Rocha, A. L., Del Puerto, H. L., Petraglia, F., & Reis, F. M. (2018). Plasma urocortin-1 as a preoperative marker of endometriosis in symptomatic women. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 34(3), 202-205. https://doi.org/10.1080/09513590.2017.1380188
Maia LM, et al. Plasma Urocortin-1 as a Preoperative Marker of Endometriosis in Symptomatic Women. Gynecol Endocrinol. 2018;34(3):202-205. PubMed PMID: 28925754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma urocortin-1 as a preoperative marker of endometriosis in symptomatic women. AU - Maia,Laura M, AU - Rocha,Ana L, AU - Del Puerto,Helen L, AU - Petraglia,Felice, AU - Reis,Fernando M, Y1 - 2017/09/19/ PY - 2017/9/20/pubmed PY - 2018/8/28/medline PY - 2017/9/20/entrez KW - biomarker KW - endometriosis KW - infertility KW - pain KW - urocortin-1 SP - 202 EP - 205 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 34 IS - 3 N2 - Accurate noninvasive diagnostic tests for endometriosis are still missing. This study evaluated the predictive value of the neuropeptide urocortin 1 (Ucn1) to detect pelvic endometriosis in symptomatic women. We enrolled prospectively 97 consecutive women submitted to gynecologic laparoscopy for chronic or acute pelvic pain, infertility or adnexal mass. Preoperative blood samples were assayed for Ucn1 using enzyme immunoassay. Patients with endometriosis had higher plasma Ucn1 levels compared to patients with no lesions (median 59 vs. 34 pg/ml, p < .01, Dunn's test). Elevated plasma Ucn1 levels were found among all endometriosis phenotypes (superficial peritoneal lesions, ovarian endometrioma, and deep infiltrating endometriosis, p < .05 vs. no lesions). Receiver operating characteristics curve analysis identified plasma Ucn1 > 46 pg/mL as the best cutoff point to detect endometriosis vs. no lesions, with 76% sensitivity and 88% specificity (area under the curve [AUC] 0.827, 95% confidence interval [CI] 0.695 - 0.959), but no cutoff could accurately distinguish endometriosis from other pathological conditions (AUC 0.593 [95% CI 0.474 - 0.711]). In women with chronic pelvic pain, infertility, or both symptoms, the probability of endometriosis (positive predictive value) increased consistently with the increase of plasma Ucn1 levels. The present findings suggest that high plasma Ucn1 levels increase the likelihood of endometriosis in symptomatic women. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/28925754/Plasma_urocortin_1_as_a_preoperative_marker_of_endometriosis_in_symptomatic_women_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590.2017.1380188 DB - PRIME DP - Unbound Medicine ER -