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Clinical Significance of Soluble Intercellular Adhesion Molecule-1 and Interleukin-6 in Patients with Extrahepatic Cholangiocarcinoma.
J Invest Surg. 2018 Dec; 31(6):475-482.JI

Abstract

Purpose/

Aim:

Although several prognostic factors for extrahepatic cholangiocarcinoma (EHC) have been reported, preoperative prognostic factors have yet to be established. We investigated the serum concentration of angiogenic, inflammatory, and nutritional parameters.

MATERIALS AND METHODS

Twenty-five patients with EHC were enrolled before starting treatment. Preoperative prognostic factors were identified using multivariate analyses.

RESULTS

The serum soluble intercellular adhesion molecule-1 (sICAM-1) levels were significantly higher in the patients with EHC (436.0 ± 43.2 ng/ml) than in the healthy volunteers (228.6 ± 22.0 ng/ml) (p <.001). In addition, the serum IL-6 levels were significantly higher in the patients (18.0 ± 5.6 pg/ml) than in the healthy volunteers (5.7 ± 0.8 pg/ml) (p <.05). The serum IL-6 and sICAM-1 showed a strong correlation (r = 0.559) in the patients with EHC (p <.01). The serum IL-6 (area under the curve = 0.764, p =.030, cut-off level = 11.6) and sICAM-1 (area under the curve = 0.818, p =.007, cutoff level = 322.6) were revealed to be useful as prognostic factors by the receiver operating characteristic curves. The high IL-6 group and the high sICAM-1 group showed poorer DSS than those of the respective low groups. In the multivariate analysis, IL-6 (hazard ratio: 1.050, 95% confidence interval: 1.002-1.100, p =.043) and sICAM-1 (hazard ratio: 1.009, 95% confidence interval: 1.002-1.015, p =.009) were independent prognostic factors for DSS.

CONCLUSIONS

IL-6 and sICAM-1 were independent preoperative prognostic factors in EHC patients, causing continuous inflammation and malnutrition in collaboration with other pro-angiogenic factors.

Authors+Show Affiliations

a Department of Organ Regulatory Surgery , Fukushima Medical University , 1 Hikarigaoka, Fukushima, Fukushima , Japan.a Department of Organ Regulatory Surgery , Fukushima Medical University , 1 Hikarigaoka, Fukushima, Fukushima , Japan.a Department of Organ Regulatory Surgery , Fukushima Medical University , 1 Hikarigaoka, Fukushima, Fukushima , Japan.a Department of Organ Regulatory Surgery , Fukushima Medical University , 1 Hikarigaoka, Fukushima, Fukushima , Japan.a Department of Organ Regulatory Surgery , Fukushima Medical University , 1 Hikarigaoka, Fukushima, Fukushima , Japan.a Department of Organ Regulatory Surgery , Fukushima Medical University , 1 Hikarigaoka, Fukushima, Fukushima , Japan.b Department of Organ Regenerative Surgery , Fukushima Medical University , 1 Hikarigaoka, Fukushima, Fukushima , Japan.b Department of Organ Regenerative Surgery , Fukushima Medical University , 1 Hikarigaoka, Fukushima, Fukushima , Japan.b Department of Organ Regenerative Surgery , Fukushima Medical University , 1 Hikarigaoka, Fukushima, Fukushima , Japan.a Department of Organ Regulatory Surgery , Fukushima Medical University , 1 Hikarigaoka, Fukushima, Fukushima , Japan.a Department of Organ Regulatory Surgery , Fukushima Medical University , 1 Hikarigaoka, Fukushima, Fukushima , Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28925763

Citation

Shimura, Tatsuo, et al. "Clinical Significance of Soluble Intercellular Adhesion Molecule-1 and Interleukin-6 in Patients With Extrahepatic Cholangiocarcinoma." Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research, vol. 31, no. 6, 2018, pp. 475-482.
Shimura T, Shibata M, Gonda K, et al. Clinical Significance of Soluble Intercellular Adhesion Molecule-1 and Interleukin-6 in Patients with Extrahepatic Cholangiocarcinoma. J Invest Surg. 2018;31(6):475-482.
Shimura, T., Shibata, M., Gonda, K., Kofunato, Y., Okada, R., Ishigame, T., Kimura, T., Kenjo, A., Marubashi, S., Kono, K., & Takenoshita, S. (2018). Clinical Significance of Soluble Intercellular Adhesion Molecule-1 and Interleukin-6 in Patients with Extrahepatic Cholangiocarcinoma. Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research, 31(6), 475-482. https://doi.org/10.1080/08941939.2017.1358310
Shimura T, et al. Clinical Significance of Soluble Intercellular Adhesion Molecule-1 and Interleukin-6 in Patients With Extrahepatic Cholangiocarcinoma. J Invest Surg. 2018;31(6):475-482. PubMed PMID: 28925763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Significance of Soluble Intercellular Adhesion Molecule-1 and Interleukin-6 in Patients with Extrahepatic Cholangiocarcinoma. AU - Shimura,Tatsuo, AU - Shibata,Masahiko, AU - Gonda,Kenji, AU - Kofunato,Yasuhide, AU - Okada,Ryo, AU - Ishigame,Teruhide, AU - Kimura,Takashi, AU - Kenjo,Akira, AU - Marubashi,Shigeru, AU - Kono,Koji, AU - Takenoshita,Seiichi, Y1 - 2017/09/19/ PY - 2017/9/20/pubmed PY - 2019/8/27/medline PY - 2017/9/20/entrez KW - extrahepatic cholangiocarcinoma KW - interleukin-6 KW - preoperative prognostic factor KW - soluble intercellular adhesion molecule-1 SP - 475 EP - 482 JF - Journal of investigative surgery : the official journal of the Academy of Surgical Research JO - J Invest Surg VL - 31 IS - 6 N2 - : Purpose/Aim: Although several prognostic factors for extrahepatic cholangiocarcinoma (EHC) have been reported, preoperative prognostic factors have yet to be established. We investigated the serum concentration of angiogenic, inflammatory, and nutritional parameters. MATERIALS AND METHODS: Twenty-five patients with EHC were enrolled before starting treatment. Preoperative prognostic factors were identified using multivariate analyses. RESULTS: The serum soluble intercellular adhesion molecule-1 (sICAM-1) levels were significantly higher in the patients with EHC (436.0 ± 43.2 ng/ml) than in the healthy volunteers (228.6 ± 22.0 ng/ml) (p <.001). In addition, the serum IL-6 levels were significantly higher in the patients (18.0 ± 5.6 pg/ml) than in the healthy volunteers (5.7 ± 0.8 pg/ml) (p <.05). The serum IL-6 and sICAM-1 showed a strong correlation (r = 0.559) in the patients with EHC (p <.01). The serum IL-6 (area under the curve = 0.764, p =.030, cut-off level = 11.6) and sICAM-1 (area under the curve = 0.818, p =.007, cutoff level = 322.6) were revealed to be useful as prognostic factors by the receiver operating characteristic curves. The high IL-6 group and the high sICAM-1 group showed poorer DSS than those of the respective low groups. In the multivariate analysis, IL-6 (hazard ratio: 1.050, 95% confidence interval: 1.002-1.100, p =.043) and sICAM-1 (hazard ratio: 1.009, 95% confidence interval: 1.002-1.015, p =.009) were independent prognostic factors for DSS. CONCLUSIONS: IL-6 and sICAM-1 were independent preoperative prognostic factors in EHC patients, causing continuous inflammation and malnutrition in collaboration with other pro-angiogenic factors. SN - 1521-0553 UR - https://www.unboundmedicine.com/medline/citation/28925763/Clinical_Significance_of_Soluble_Intercellular_Adhesion_Molecule_1_and_Interleukin_6_in_Patients_with_Extrahepatic_Cholangiocarcinoma_ L2 - https://www.tandfonline.com/doi/full/10.1080/08941939.2017.1358310 DB - PRIME DP - Unbound Medicine ER -