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Developments in the formulation and delivery of spray dried vaccines.
Hum Vaccin Immunother. 2017 10 03; 13(10):2364-2378.HV

Abstract

Spray drying is a promising method for the stabilization of vaccines, which are usually formulated as liquids. Usually, vaccine stability is improved by spray drying in the presence of a range of excipients. Unlike freeze drying, there is no freezing step involved, thus the damage related to this step is avoided. The edge of spray drying resides in its ability for particles to be engineered to desired requirements, which can be used in various vaccine delivery methods and routes. Although several spray dried vaccines have shown encouraging preclinical results, the number of vaccines that have been tested in clinical trials is limited, indicating a relatively new area of vaccine stabilization and delivery. This article reviews the current status of spray dried vaccine formulations and delivery methods. In particular it discusses the impact of process stresses on vaccine integrity, the application of excipients in spray drying of vaccines, process and formulation optimization strategies based on Design of Experiment approaches as well as opportunities for future application of spray dried vaccine powders for vaccine delivery.

Authors+Show Affiliations

a Intravacc (Institute for Translational Vaccinology) , Bilthoven , The Netherlands. b Department of Pharmaceutical Technology and Biopharmacy , University of Groningen , Groningen , The Netherlands.a Intravacc (Institute for Translational Vaccinology) , Bilthoven , The Netherlands.a Intravacc (Institute for Translational Vaccinology) , Bilthoven , The Netherlands.b Department of Pharmaceutical Technology and Biopharmacy , University of Groningen , Groningen , The Netherlands.d Virtuvax BV , Odijk , The Netherlands.a Intravacc (Institute for Translational Vaccinology) , Bilthoven , The Netherlands. c Division of Drug Delivery Technology, Leiden Academic Center for Drug Research , Leiden University , Leiden , The Netherlands.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28925794

Citation

Kanojia, Gaurav, et al. "Developments in the Formulation and Delivery of Spray Dried Vaccines." Human Vaccines & Immunotherapeutics, vol. 13, no. 10, 2017, pp. 2364-2378.
Kanojia G, Have RT, Soema PC, et al. Developments in the formulation and delivery of spray dried vaccines. Hum Vaccin Immunother. 2017;13(10):2364-2378.
Kanojia, G., Have, R. T., Soema, P. C., Frijlink, H., Amorij, J. P., & Kersten, G. (2017). Developments in the formulation and delivery of spray dried vaccines. Human Vaccines & Immunotherapeutics, 13(10), 2364-2378. https://doi.org/10.1080/21645515.2017.1356952
Kanojia G, et al. Developments in the Formulation and Delivery of Spray Dried Vaccines. Hum Vaccin Immunother. 2017 10 3;13(10):2364-2378. PubMed PMID: 28925794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Developments in the formulation and delivery of spray dried vaccines. AU - Kanojia,Gaurav, AU - Have,Rimko Ten, AU - Soema,Peter C, AU - Frijlink,Henderik, AU - Amorij,Jean-Pierre, AU - Kersten,Gideon, PY - 2017/9/20/pubmed PY - 2018/6/12/medline PY - 2017/9/20/entrez KW - Delivery KW - Dry Powder Vaccine KW - Formulation and Design of Experiments KW - Spray drying KW - Vaccine SP - 2364 EP - 2378 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 13 IS - 10 N2 - Spray drying is a promising method for the stabilization of vaccines, which are usually formulated as liquids. Usually, vaccine stability is improved by spray drying in the presence of a range of excipients. Unlike freeze drying, there is no freezing step involved, thus the damage related to this step is avoided. The edge of spray drying resides in its ability for particles to be engineered to desired requirements, which can be used in various vaccine delivery methods and routes. Although several spray dried vaccines have shown encouraging preclinical results, the number of vaccines that have been tested in clinical trials is limited, indicating a relatively new area of vaccine stabilization and delivery. This article reviews the current status of spray dried vaccine formulations and delivery methods. In particular it discusses the impact of process stresses on vaccine integrity, the application of excipients in spray drying of vaccines, process and formulation optimization strategies based on Design of Experiment approaches as well as opportunities for future application of spray dried vaccine powders for vaccine delivery. SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/28925794/Developments_in_the_formulation_and_delivery_of_spray_dried_vaccines_ L2 - http://www.tandfonline.com/doi/full/10.1080/21645515.2017.1356952 DB - PRIME DP - Unbound Medicine ER -