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Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor κ-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats.
Neuroreport. 2017 Dec 06; 28(17):1170-1175.N

Abstract

Anesthesia neurotoxicity in developing brain has gained increasing attention. However, knowledge regarding its mitigating strategies remains scant. Sevoflurane, a commonly used anesthetic, is responsible for learning and memory deficits in neonates. Molecular hydrogen is reported to be a potential neuroprotective agent because of its antioxidative and anti-inflammatory activities. This study aimed to investigate the effect of hydrogen gas on sevoflurane neurotoxicity. The newborn rats were treated with sevoflurane and/or hydrogen gas for 2 h. Spatial recognition memory and fear memory were determined by Y-maze and fear conditioning tests at 10 weeks of age. Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) and proinflammatory cytokine levels were detected using western blot analysis. The data showed that the spatial recognition memory and fear memory of the rats treated with sevoflurane decreased compared with the control, and the cognitive function of the rats treated with sevoflurane and hydrogen gas significantly increased in comparison with treatment with sevoflurane alone. Moreover, hydrogen gas suppressed NF-κB phosphorylation and nuclear translocation and reduced the production of interleukin-1β, interleukin-6, and tumor necrosis factor-α following sevoflurane administration. Thus, the results proposed that hydrogen gas might protect against sevoflurane neurotoxicity by inhibiting NF-κB activation and proinflammatory cytokine release, providing a novel therapeutic strategy for anesthesia neurotoxicity.

Authors+Show Affiliations

Department of Anesthesiology, Tianjin First Center Hospital, Tianjin, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28926473

Citation

Shi, Yiwei, et al. "Hydrogen Gas Attenuates Sevoflurane Neurotoxicity Through Inhibiting Nuclear Factor Κ-light-chain-enhancer of Activated B Cells Signaling and Proinflammatory Cytokine Release in Neonatal Rats." Neuroreport, vol. 28, no. 17, 2017, pp. 1170-1175.
Shi Y, Wang G, Li J, et al. Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor κ-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats. Neuroreport. 2017;28(17):1170-1175.
Shi, Y., Wang, G., Li, J., & Yu, W. (2017). Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor κ-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats. Neuroreport, 28(17), 1170-1175. https://doi.org/10.1097/WNR.0000000000000899
Shi Y, et al. Hydrogen Gas Attenuates Sevoflurane Neurotoxicity Through Inhibiting Nuclear Factor Κ-light-chain-enhancer of Activated B Cells Signaling and Proinflammatory Cytokine Release in Neonatal Rats. Neuroreport. 2017 Dec 6;28(17):1170-1175. PubMed PMID: 28926473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor κ-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats. AU - Shi,Yiwei, AU - Wang,Gang, AU - Li,Jinyuan, AU - Yu,Wenli, PY - 2017/9/20/pubmed PY - 2018/6/21/medline PY - 2017/9/20/entrez SP - 1170 EP - 1175 JF - Neuroreport JO - Neuroreport VL - 28 IS - 17 N2 - Anesthesia neurotoxicity in developing brain has gained increasing attention. However, knowledge regarding its mitigating strategies remains scant. Sevoflurane, a commonly used anesthetic, is responsible for learning and memory deficits in neonates. Molecular hydrogen is reported to be a potential neuroprotective agent because of its antioxidative and anti-inflammatory activities. This study aimed to investigate the effect of hydrogen gas on sevoflurane neurotoxicity. The newborn rats were treated with sevoflurane and/or hydrogen gas for 2 h. Spatial recognition memory and fear memory were determined by Y-maze and fear conditioning tests at 10 weeks of age. Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) and proinflammatory cytokine levels were detected using western blot analysis. The data showed that the spatial recognition memory and fear memory of the rats treated with sevoflurane decreased compared with the control, and the cognitive function of the rats treated with sevoflurane and hydrogen gas significantly increased in comparison with treatment with sevoflurane alone. Moreover, hydrogen gas suppressed NF-κB phosphorylation and nuclear translocation and reduced the production of interleukin-1β, interleukin-6, and tumor necrosis factor-α following sevoflurane administration. Thus, the results proposed that hydrogen gas might protect against sevoflurane neurotoxicity by inhibiting NF-κB activation and proinflammatory cytokine release, providing a novel therapeutic strategy for anesthesia neurotoxicity. SN - 1473-558X UR - https://www.unboundmedicine.com/medline/citation/28926473/Hydrogen_gas_attenuates_sevoflurane_neurotoxicity_through_inhibiting_nuclear_factor_κ_light_chain_enhancer_of_activated_B_cells_signaling_and_proinflammatory_cytokine_release_in_neonatal_rats_ L2 - http://dx.doi.org/10.1097/WNR.0000000000000899 DB - PRIME DP - Unbound Medicine ER -