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Antioxidant intake from diet and supplements and risk of digestive cancers in middle-aged adults: results from the prospective NutriNet-Santé cohort.

Abstract

Experimental studies suggest beneficial effects of antioxidants in digestive cancer prevention. However, epidemiological results are contrasting and few studies quantitatively assessed supplemental intake. This study aimed at investigating the associations between antioxidant intakes (dietary, supplemental and total) and digestive cancer risk. This prospective study included 38 812 middle-aged subjects (≥45 years) from the NutriNet-Santé cohort (2009-2016). Dietary data were collected using repeated 24 h records. A specific questionnaire assessed dietary supplement use over a 12-month period. A composition database of about 8000 dietary supplements was developed. Associations between continuous and sex-specific quartiles of vitamins C and E, β-carotene and Se intakes and digestive cancer risk were characterised using multivariable Cox proportional hazard models. A total of 167 incident digestive cancers (120 colorectal, twenty-six pancreatic, nine oesophagus, seven stomach and five liver) were diagnosed during follow-up investigation. Dietary (hazard ratios (HR)Q4 v. Q1=0·56; 95 % CI 0·34, 0·91, P trend=0·01) and total (HRQ4 v. Q1=0·51; 95 % CI 0·30, 0·84, P trend=0·008) vitamin C intakes, dietary (HRQ4 v. Q1=0·56; 95 % CI 0·34, 0·92, P trend=0·005) and total (HRQ4 v. Q1=0·58; 95 % CI 0·36, 0·94, P trend=0·003) vitamin E intakes, and dietary (HRfor an increment of 10 µg/d=0·92; 95 % CI 0·85, 1·00, P=0·04) and total (HRfor an increment of 10 µg/d=0·92; 95 % CI 0·86, 0·99, P=0·03) Se intakes were associated with a decreased digestive cancer risk. Statistically significant interactions were observed between dietary and total Se intakes and alcohol consumption as well as between total vitamin E intake and smoking status. This prospective cohort study with quantitative assessment of supplemental intakes suggests a potential protective effect of several antioxidants (vitamins C and E and Se) on digestive cancer risk, and a modulation of some of these relationships by alcohol consumption and smoking status.

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  • Authors+Show Affiliations

    ,

    1Nutritional Epidemiology Research Team (EREN),Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS),Institute for Health and Medical Research (Inserm, U1153),Institut National de la Recherche Agronomique (INRA, U1125),Conservatoire National des Arts et Métiers (CNAM),University Paris 13,93000 Bobigny,France.

    ,

    1Nutritional Epidemiology Research Team (EREN),Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS),Institute for Health and Medical Research (Inserm, U1153),Institut National de la Recherche Agronomique (INRA, U1125),Conservatoire National des Arts et Métiers (CNAM),University Paris 13,93000 Bobigny,France.

    ,

    1Nutritional Epidemiology Research Team (EREN),Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS),Institute for Health and Medical Research (Inserm, U1153),Institut National de la Recherche Agronomique (INRA, U1125),Conservatoire National des Arts et Métiers (CNAM),University Paris 13,93000 Bobigny,France.

    ,

    1Nutritional Epidemiology Research Team (EREN),Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS),Institute for Health and Medical Research (Inserm, U1153),Institut National de la Recherche Agronomique (INRA, U1125),Conservatoire National des Arts et Métiers (CNAM),University Paris 13,93000 Bobigny,France.

    ,

    1Nutritional Epidemiology Research Team (EREN),Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS),Institute for Health and Medical Research (Inserm, U1153),Institut National de la Recherche Agronomique (INRA, U1125),Conservatoire National des Arts et Métiers (CNAM),University Paris 13,93000 Bobigny,France.

    ,

    3UFR Pharmacie,UMR 1019,Centre de Recherches en Nutrition Humaine (CRNH) Auvergne,Centre Jean-Perrin,Clermont UniversitéAuvergne,Institut National de la Recherche Agronomique (INRA),CHU Gabriel-Montpied,Unité de Nutrition, 63009 Clermont-Ferrand, France.

    ,

    1Nutritional Epidemiology Research Team (EREN),Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS),Institute for Health and Medical Research (Inserm, U1153),Institut National de la Recherche Agronomique (INRA, U1125),Conservatoire National des Arts et Métiers (CNAM),University Paris 13,93000 Bobigny,France.

    ,

    1Nutritional Epidemiology Research Team (EREN),Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS),Institute for Health and Medical Research (Inserm, U1153),Institut National de la Recherche Agronomique (INRA, U1125),Conservatoire National des Arts et Métiers (CNAM),University Paris 13,93000 Bobigny,France.

    ,

    1Nutritional Epidemiology Research Team (EREN),Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS),Institute for Health and Medical Research (Inserm, U1153),Institut National de la Recherche Agronomique (INRA, U1125),Conservatoire National des Arts et Métiers (CNAM),University Paris 13,93000 Bobigny,France.

    ,

    1Nutritional Epidemiology Research Team (EREN),Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS),Institute for Health and Medical Research (Inserm, U1153),Institut National de la Recherche Agronomique (INRA, U1125),Conservatoire National des Arts et Métiers (CNAM),University Paris 13,93000 Bobigny,France.

    ,

    1Nutritional Epidemiology Research Team (EREN),Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS),Institute for Health and Medical Research (Inserm, U1153),Institut National de la Recherche Agronomique (INRA, U1125),Conservatoire National des Arts et Métiers (CNAM),University Paris 13,93000 Bobigny,France.

    1Nutritional Epidemiology Research Team (EREN),Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS),Institute for Health and Medical Research (Inserm, U1153),Institut National de la Recherche Agronomique (INRA, U1125),Conservatoire National des Arts et Métiers (CNAM),University Paris 13,93000 Bobigny,France.

    Source

    The British journal of nutrition 118:7 2017 Oct pg 541-549

    MeSH

    Antioxidants
    Ascorbic Acid
    Diet
    Dietary Supplements
    Digestive System Neoplasms
    Female
    Humans
    Male
    Middle Aged
    Multivariate Analysis
    Nutrition Assessment
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Selenium
    Surveys and Questionnaires
    Vitamin E
    beta Carotene

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28927476

    Citation

    Egnell, Manon, et al. "Antioxidant Intake From Diet and Supplements and Risk of Digestive Cancers in Middle-aged Adults: Results From the Prospective NutriNet-Santé Cohort." The British Journal of Nutrition, vol. 118, no. 7, 2017, pp. 541-549.
    Egnell M, Fassier P, Lécuyer L, et al. Antioxidant intake from diet and supplements and risk of digestive cancers in middle-aged adults: results from the prospective NutriNet-Santé cohort. Br J Nutr. 2017;118(7):541-549.
    Egnell, M., Fassier, P., Lécuyer, L., Gonzalez, R., Zelek, L., Vasson, M. P., ... Touvier, M. (2017). Antioxidant intake from diet and supplements and risk of digestive cancers in middle-aged adults: results from the prospective NutriNet-Santé cohort. The British Journal of Nutrition, 118(7), pp. 541-549. doi:10.1017/S0007114517002392.
    Egnell M, et al. Antioxidant Intake From Diet and Supplements and Risk of Digestive Cancers in Middle-aged Adults: Results From the Prospective NutriNet-Santé Cohort. Br J Nutr. 2017;118(7):541-549. PubMed PMID: 28927476.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antioxidant intake from diet and supplements and risk of digestive cancers in middle-aged adults: results from the prospective NutriNet-Santé cohort. AU - Egnell,Manon, AU - Fassier,Philippine, AU - Lécuyer,Lucie, AU - Gonzalez,Rebeca, AU - Zelek,Laurent, AU - Vasson,Marie-Paule, AU - Hercberg,Serge, AU - Latino-Martel,Paule, AU - Galan,Pilar, AU - Druesne-Pecollo,Nathalie, AU - Deschasaux,Mélanie, AU - Touvier,Mathilde, Y1 - 2017/09/20/ PY - 2017/9/21/pubmed PY - 2017/10/19/medline PY - 2017/9/21/entrez KW - HR hazard ratio KW - IPAQ International Physical Activity Questionnaire KW - Antioxidants KW - Diet KW - Dietary supplements KW - Digestive cancers KW - Prospective cohorts SP - 541 EP - 549 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 118 IS - 7 N2 - Experimental studies suggest beneficial effects of antioxidants in digestive cancer prevention. However, epidemiological results are contrasting and few studies quantitatively assessed supplemental intake. This study aimed at investigating the associations between antioxidant intakes (dietary, supplemental and total) and digestive cancer risk. This prospective study included 38 812 middle-aged subjects (≥45 years) from the NutriNet-Santé cohort (2009-2016). Dietary data were collected using repeated 24 h records. A specific questionnaire assessed dietary supplement use over a 12-month period. A composition database of about 8000 dietary supplements was developed. Associations between continuous and sex-specific quartiles of vitamins C and E, β-carotene and Se intakes and digestive cancer risk were characterised using multivariable Cox proportional hazard models. A total of 167 incident digestive cancers (120 colorectal, twenty-six pancreatic, nine oesophagus, seven stomach and five liver) were diagnosed during follow-up investigation. Dietary (hazard ratios (HR)Q4 v. Q1=0·56; 95 % CI 0·34, 0·91, P trend=0·01) and total (HRQ4 v. Q1=0·51; 95 % CI 0·30, 0·84, P trend=0·008) vitamin C intakes, dietary (HRQ4 v. Q1=0·56; 95 % CI 0·34, 0·92, P trend=0·005) and total (HRQ4 v. Q1=0·58; 95 % CI 0·36, 0·94, P trend=0·003) vitamin E intakes, and dietary (HRfor an increment of 10 µg/d=0·92; 95 % CI 0·85, 1·00, P=0·04) and total (HRfor an increment of 10 µg/d=0·92; 95 % CI 0·86, 0·99, P=0·03) Se intakes were associated with a decreased digestive cancer risk. Statistically significant interactions were observed between dietary and total Se intakes and alcohol consumption as well as between total vitamin E intake and smoking status. This prospective cohort study with quantitative assessment of supplemental intakes suggests a potential protective effect of several antioxidants (vitamins C and E and Se) on digestive cancer risk, and a modulation of some of these relationships by alcohol consumption and smoking status. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/28927476/Antioxidant_intake_from_diet_and_supplements_and_risk_of_digestive_cancers_in_middle_aged_adults:_results_from_the_prospective_NutriNet_Santé_cohort_ L2 - https://www.cambridge.org/core/product/identifier/S0007114517002392/type/journal_article DB - PRIME DP - Unbound Medicine ER -