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Oxidative stress in inflammatory cells of patient with rheumatoid arthritis: clinical efficacy of dietary antioxidants.
Inflammopharmacology. 2017 Dec; 25(6):595-607.I

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease responsible for significant human morbidity in modern life. However, oxidative stress is one of the key markers for determining pathophysiology of patients with RA. The interaction between cellular immune system and body's endogenous and/or exogenous antigens produce reactive oxygen species (ROS) and reactive nitrogen species (RNS) in autoimmune disease like RA. ROS and RNS include highly toxic superoxide (O2-) and peroxynitrite (ONOO-) radicals, which activate the signaling cascades of inflammatory cells to synthesize pro-inflammatory cytokines and chemokines. Previous studies reported that Th1 cytokines could promote the development of autoimmune disorders like RA, whereas the Th2 cytokines may attenuate the same diseases. An increased awareness of the relationship between food and health led to a tremendous increase of antioxidant research in the last decade. Evaluation of the efficacy of dietary antioxidants is also becoming highly acceptable in RA research. A number of dietary phytomolecules are already established as having antioxidant activity in isolated synovial cellular infiltrate or peripheral blood neutrophils and lymphocytes. This review aims to highlight the oxidative stress in inflammatory cells of patients with RA and to summarize the clinical relevance of dietary antioxidants as a first step in assessing beneficial effect, safety and dose safety ratio in patients with RA.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Bala A
Department of Pharmacology, Faculty of Health Science, University of the Free State, Bloemfontein, 9301, Free State, South Africa. asisbala_ju@yahoo.co.in. Division of Pharmacology, Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F Nilgunj Road, Panihati, West Bengal, 700114, India. asisbala_ju@yahoo.co.in.
Mondal C
TCG Life Sciences (Chembiotek) Pvt. Ltd., Sector V, Salt Lake Electronics Complex, Kolkata, West Bengal, 700091, India.
Haldar PK
Department of Pharmaceutical Technology, Jadavpur University, 188B Raja S.C. Mullick Road, Kolkata, West Bengal, 700032, India.
Khandelwal B
Department of Medicine, Sikkim Manipal Institute of Medical Science, 5th Mile Tadong, Gangtok, Sikkim, 737102, India.

MeSH

AnimalsAntioxidantsArthritis, RheumatoidCytokinesDietHumansInflammationOxidative StressReactive Nitrogen SpeciesReactive Oxygen Species

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28929423

Citation

Bala, Asis, et al. "Oxidative Stress in Inflammatory Cells of Patient With Rheumatoid Arthritis: Clinical Efficacy of Dietary Antioxidants." Inflammopharmacology, vol. 25, no. 6, 2017, pp. 595-607.
Bala A, Mondal C, Haldar PK, et al. Oxidative stress in inflammatory cells of patient with rheumatoid arthritis: clinical efficacy of dietary antioxidants. Inflammopharmacology. 2017;25(6):595-607.
Bala, A., Mondal, C., Haldar, P. K., & Khandelwal, B. (2017). Oxidative stress in inflammatory cells of patient with rheumatoid arthritis: clinical efficacy of dietary antioxidants. Inflammopharmacology, 25(6), 595-607. https://doi.org/10.1007/s10787-017-0397-1
Bala A, et al. Oxidative Stress in Inflammatory Cells of Patient With Rheumatoid Arthritis: Clinical Efficacy of Dietary Antioxidants. Inflammopharmacology. 2017;25(6):595-607. PubMed PMID: 28929423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress in inflammatory cells of patient with rheumatoid arthritis: clinical efficacy of dietary antioxidants. AU - Bala,Asis, AU - Mondal,Chaitali, AU - Haldar,Pallab Kanti, AU - Khandelwal,Bidita, Y1 - 2017/09/19/ PY - 2017/08/03/received PY - 2017/09/06/accepted PY - 2017/9/21/pubmed PY - 2018/6/22/medline PY - 2017/9/21/entrez KW - Clinical efficacy KW - Dietary antioxidants KW - Etiology KW - Inflammatory Cells KW - Oxidative stress KW - Rheumatoid arthritis SP - 595 EP - 607 JF - Inflammopharmacology JO - Inflammopharmacology VL - 25 IS - 6 N2 - Rheumatoid arthritis (RA) is an autoimmune disease responsible for significant human morbidity in modern life. However, oxidative stress is one of the key markers for determining pathophysiology of patients with RA. The interaction between cellular immune system and body's endogenous and/or exogenous antigens produce reactive oxygen species (ROS) and reactive nitrogen species (RNS) in autoimmune disease like RA. ROS and RNS include highly toxic superoxide (O2-) and peroxynitrite (ONOO-) radicals, which activate the signaling cascades of inflammatory cells to synthesize pro-inflammatory cytokines and chemokines. Previous studies reported that Th1 cytokines could promote the development of autoimmune disorders like RA, whereas the Th2 cytokines may attenuate the same diseases. An increased awareness of the relationship between food and health led to a tremendous increase of antioxidant research in the last decade. Evaluation of the efficacy of dietary antioxidants is also becoming highly acceptable in RA research. A number of dietary phytomolecules are already established as having antioxidant activity in isolated synovial cellular infiltrate or peripheral blood neutrophils and lymphocytes. This review aims to highlight the oxidative stress in inflammatory cells of patients with RA and to summarize the clinical relevance of dietary antioxidants as a first step in assessing beneficial effect, safety and dose safety ratio in patients with RA. SN - 1568-5608 UR - https://www.unboundmedicine.com/medline/citation/28929423/Oxidative_stress_in_inflammatory_cells_of_patient_with_rheumatoid_arthritis:_clinical_efficacy_of_dietary_antioxidants_ DB - PRIME DP - Unbound Medicine ER -