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Factors extending the chronological lifespan of yeast: Ecl1 family genes.
FEMS Yeast Res. 2017 11 01; 17(7)FY

Abstract

Ecl1 family genes are conserved among yeast, in which their overexpression extends chronological lifespan. Ecl1 family genes were first identified in the fission yeast Schizosaccharomyces pombe; at the time, they were considered noncoding RNA owing to their short coding sequence of fewer than 300 base pairs. Schizosaccharomyces pombe carries three Ecl1 family genes, ecl1+, ecl2+ and ecl3+, whereas Saccharomyces cerevisiae has one, ECL1. Their overexpression extends chronological lifespan, increases oxidative stress resistance and induces sexual development in fission yeast. A recent study indicated that Ecl1 family genes play a significant role in responding to environmental zinc or sulfur depletion. In this review, we focus on Ecl1 family genes in fission yeast and describe the relationship between nutritional depletion and cellular output, as the latter depends on Ecl1 family genes. Furthermore, we present the roles and functions of Ecl1 family genes characterized to date.

Authors+Show Affiliations

Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan.Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28934413

Citation

Ohtsuka, Hokuto, and Hirofumi Aiba. "Factors Extending the Chronological Lifespan of Yeast: Ecl1 Family Genes." FEMS Yeast Research, vol. 17, no. 7, 2017.
Ohtsuka H, Aiba H. Factors extending the chronological lifespan of yeast: Ecl1 family genes. FEMS Yeast Res. 2017;17(7).
Ohtsuka, H., & Aiba, H. (2017). Factors extending the chronological lifespan of yeast: Ecl1 family genes. FEMS Yeast Research, 17(7). https://doi.org/10.1093/femsyr/fox066
Ohtsuka H, Aiba H. Factors Extending the Chronological Lifespan of Yeast: Ecl1 Family Genes. FEMS Yeast Res. 2017 11 1;17(7) PubMed PMID: 28934413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors extending the chronological lifespan of yeast: Ecl1 family genes. AU - Ohtsuka,Hokuto, AU - Aiba,Hirofumi, PY - 2017/06/15/received PY - 2017/08/18/accepted PY - 2017/9/22/entrez PY - 2017/9/22/pubmed PY - 2018/5/25/medline KW - Ecl1 KW - Schizossacharomyces pombe KW - calorie restriction KW - chronological lifespan KW - ribosomal protein KW - sexual development JF - FEMS yeast research JO - FEMS Yeast Res VL - 17 IS - 7 N2 - Ecl1 family genes are conserved among yeast, in which their overexpression extends chronological lifespan. Ecl1 family genes were first identified in the fission yeast Schizosaccharomyces pombe; at the time, they were considered noncoding RNA owing to their short coding sequence of fewer than 300 base pairs. Schizosaccharomyces pombe carries three Ecl1 family genes, ecl1+, ecl2+ and ecl3+, whereas Saccharomyces cerevisiae has one, ECL1. Their overexpression extends chronological lifespan, increases oxidative stress resistance and induces sexual development in fission yeast. A recent study indicated that Ecl1 family genes play a significant role in responding to environmental zinc or sulfur depletion. In this review, we focus on Ecl1 family genes in fission yeast and describe the relationship between nutritional depletion and cellular output, as the latter depends on Ecl1 family genes. Furthermore, we present the roles and functions of Ecl1 family genes characterized to date. SN - 1567-1364 UR - https://www.unboundmedicine.com/medline/citation/28934413/Factors_extending_the_chronological_lifespan_of_yeast:_Ecl1_family_genes_ L2 - https://academic.oup.com/femsyr/article-lookup/doi/10.1093/femsyr/fox066 DB - PRIME DP - Unbound Medicine ER -