Tags

Type your tag names separated by a space and hit enter

Choroidal thickness and axial length changes in myopic children treated with orthokeratology.
Cont Lens Anterior Eye. 2017 Dec; 40(6):417-423.CL

Abstract

PURPOSE

To analyze the change in subfoveal choroidal thickness (SFChT) and its relationship with changes in axial length (AL) in myopic children treated with Orthokeratology (Ortho-k).

METHODS

Fifty myopic children participated in this study: 29 subjects were treated with Ortho-k lenses and 21 with single vision distance spectacles. The SFChT and ocular biometrics, including AL, were measured at baseline, one month, and six months after lens wear in both groups.

RESULTS

AL significantly increased in both groups over time. In the Ortho-k group, SFChT also increased; however, there was no significant change in SFChT in the control group over time. At the six-month visit, the magnitude of eye growth was significantly reduced in the Ortho-k group compared to the control group (0.06±0.10mm vs. 0.17±0.10mm, P<0.001). SFChT was significantly thicker in the Ortho-k group compared to the control group at the one-month and six-month visits (15.78±11.37μm vs. -2.98±8.96μm, P<0.001 (one-month visit); 21.03±12.74μm vs. -2.50±14.43μm, P<0.001 (six-month visit)), although there was no significant difference between the two follow-up visits (P=0.102 for the Ortho-k group; P=0.898 for the control group). Changes in the large choroidal vascular layer (LCVL) accounted for the majority of subfoveal choroidal thickening (approximately 77% and 80% at one-month and six-month visits, respectively).

CONCLUSION

Ortho-k treatment induced significant choroidal thickening and a slowing of eye growth. LCVL thickening accounted for the majority of SFChT thickening. However, its potential mechanism in myopia control requires further investigation.

Authors+Show Affiliations

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address: yangxiao3366@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28935528

Citation

Li, Zhouyue, et al. "Choroidal Thickness and Axial Length Changes in Myopic Children Treated With Orthokeratology." Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association, vol. 40, no. 6, 2017, pp. 417-423.
Li Z, Cui D, Hu Y, et al. Choroidal thickness and axial length changes in myopic children treated with orthokeratology. Cont Lens Anterior Eye. 2017;40(6):417-423.
Li, Z., Cui, D., Hu, Y., Ao, S., Zeng, J., & Yang, X. (2017). Choroidal thickness and axial length changes in myopic children treated with orthokeratology. Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association, 40(6), 417-423. https://doi.org/10.1016/j.clae.2017.09.010
Li Z, et al. Choroidal Thickness and Axial Length Changes in Myopic Children Treated With Orthokeratology. Cont Lens Anterior Eye. 2017;40(6):417-423. PubMed PMID: 28935528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Choroidal thickness and axial length changes in myopic children treated with orthokeratology. AU - Li,Zhouyue, AU - Cui,Dongmei, AU - Hu,Yin, AU - Ao,Sichun, AU - Zeng,Junwen, AU - Yang,Xiao, Y1 - 2017/09/19/ PY - 2017/03/22/received PY - 2017/09/01/revised PY - 2017/09/11/accepted PY - 2017/9/25/pubmed PY - 2018/3/23/medline PY - 2017/9/23/entrez KW - Choroidal thickness KW - Optical coherence tomography KW - Orthokeratology SP - 417 EP - 423 JF - Contact lens & anterior eye : the journal of the British Contact Lens Association JO - Cont Lens Anterior Eye VL - 40 IS - 6 N2 - PURPOSE: To analyze the change in subfoveal choroidal thickness (SFChT) and its relationship with changes in axial length (AL) in myopic children treated with Orthokeratology (Ortho-k). METHODS: Fifty myopic children participated in this study: 29 subjects were treated with Ortho-k lenses and 21 with single vision distance spectacles. The SFChT and ocular biometrics, including AL, were measured at baseline, one month, and six months after lens wear in both groups. RESULTS: AL significantly increased in both groups over time. In the Ortho-k group, SFChT also increased; however, there was no significant change in SFChT in the control group over time. At the six-month visit, the magnitude of eye growth was significantly reduced in the Ortho-k group compared to the control group (0.06±0.10mm vs. 0.17±0.10mm, P<0.001). SFChT was significantly thicker in the Ortho-k group compared to the control group at the one-month and six-month visits (15.78±11.37μm vs. -2.98±8.96μm, P<0.001 (one-month visit); 21.03±12.74μm vs. -2.50±14.43μm, P<0.001 (six-month visit)), although there was no significant difference between the two follow-up visits (P=0.102 for the Ortho-k group; P=0.898 for the control group). Changes in the large choroidal vascular layer (LCVL) accounted for the majority of subfoveal choroidal thickening (approximately 77% and 80% at one-month and six-month visits, respectively). CONCLUSION: Ortho-k treatment induced significant choroidal thickening and a slowing of eye growth. LCVL thickening accounted for the majority of SFChT thickening. However, its potential mechanism in myopia control requires further investigation. SN - 1476-5411 UR - https://www.unboundmedicine.com/medline/citation/28935528/Choroidal_thickness_and_axial_length_changes_in_myopic_children_treated_with_orthokeratology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1367-0484(17)30103-0 DB - PRIME DP - Unbound Medicine ER -