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Vagal-immune interactions involved in cholinergic anti-inflammatory pathway.
Physiol Res. 2017 09 22; 66(Suppl 2):S139-S145.PR

Abstract

Inflammation and other immune responses are involved in the variety of diseases and disorders. The acute response to endotoxemia includes activation of innate immune mechanisms as well as changes in autonomic nervous activity. The autonomic nervous system and the inflammatory response are intimately linked and sympathetic and vagal nerves are thought to have anti-inflammation functions. The basic functional circuit between vagus nerve and inflammatory response was identified and the neuroimmunomodulation loop was called cholinergic anti-inflammatory pathway. Unique function of vagus nerve in the anti-inflammatory reflex arc was found in many experimental and pre-clinical studies. They brought evidence on the cholinergic signaling interacting with systemic and local inflammation, particularly suppressing immune cells function. Pharmacological/electrical modulation of vagal activity suppressed TNF-alpha and other proinflammatory cytokines production and had beneficial therapeutic effects. Many questions related to mapping, linking and targeting of vagal-immune interactions have been elucidated and brought understanding of its basic physiology and provided the initial support for development of Tracey´s inflammatory reflex. This review summarizes and critically assesses the current knowledge defining cholinergic anti-inflammatory pathway with main focus on studies employing an experimental approach and emphasizes the potential of modulation of vagally-mediated anti-inflammatory pathway in the treatment strategies.

Authors+Show Affiliations

Department of Physiology and Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia. calkovska@jfmed.uniba.sk.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28937230

Citation

Zila, I, et al. "Vagal-immune Interactions Involved in Cholinergic Anti-inflammatory Pathway." Physiological Research, vol. 66, no. Suppl 2, 2017, pp. S139-S145.
Zila I, Mokra D, Kopincova J, et al. Vagal-immune interactions involved in cholinergic anti-inflammatory pathway. Physiol Res. 2017;66(Suppl 2):S139-S145.
Zila, I., Mokra, D., Kopincova, J., Kolomaznik, M., Javorka, M., & Calkovska, A. (2017). Vagal-immune interactions involved in cholinergic anti-inflammatory pathway. Physiological Research, 66(Suppl 2), S139-S145.
Zila I, et al. Vagal-immune Interactions Involved in Cholinergic Anti-inflammatory Pathway. Physiol Res. 2017 09 22;66(Suppl 2):S139-S145. PubMed PMID: 28937230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vagal-immune interactions involved in cholinergic anti-inflammatory pathway. AU - Zila,I, AU - Mokra,D, AU - Kopincova,J, AU - Kolomaznik,M, AU - Javorka,M, AU - Calkovska,A, PY - 2017/9/23/entrez PY - 2017/9/25/pubmed PY - 2018/6/5/medline SP - S139 EP - S145 JF - Physiological research JO - Physiol Res VL - 66 IS - Suppl 2 N2 - Inflammation and other immune responses are involved in the variety of diseases and disorders. The acute response to endotoxemia includes activation of innate immune mechanisms as well as changes in autonomic nervous activity. The autonomic nervous system and the inflammatory response are intimately linked and sympathetic and vagal nerves are thought to have anti-inflammation functions. The basic functional circuit between vagus nerve and inflammatory response was identified and the neuroimmunomodulation loop was called cholinergic anti-inflammatory pathway. Unique function of vagus nerve in the anti-inflammatory reflex arc was found in many experimental and pre-clinical studies. They brought evidence on the cholinergic signaling interacting with systemic and local inflammation, particularly suppressing immune cells function. Pharmacological/electrical modulation of vagal activity suppressed TNF-alpha and other proinflammatory cytokines production and had beneficial therapeutic effects. Many questions related to mapping, linking and targeting of vagal-immune interactions have been elucidated and brought understanding of its basic physiology and provided the initial support for development of Tracey´s inflammatory reflex. This review summarizes and critically assesses the current knowledge defining cholinergic anti-inflammatory pathway with main focus on studies employing an experimental approach and emphasizes the potential of modulation of vagally-mediated anti-inflammatory pathway in the treatment strategies. SN - 1802-9973 UR - https://www.unboundmedicine.com/medline/citation/28937230/Vagal_immune_interactions_involved_in_cholinergic_anti_inflammatory_pathway_ L2 - http://www.biomed.cas.cz/physiolres/pdf/66/66_S139.pdf DB - PRIME DP - Unbound Medicine ER -