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Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years.
Environ Health Perspect. 2017 09 15; 125(9):097014.EH

Abstract

BACKGROUND

Sex-specific associations have been reported between phthalates, bisphenol A (BPA), and child behavior. No data on large study populations are available for other phenols with possible endocrine-disrupting properties.

OBJECTIVES

We aimed to study associations between prenatal exposure to phthalates and several phenols on behavior among male infants.

METHODS

We quantified 11 phthalate metabolites and nine phenols (four parabens, benzophenone-3, BPA, two dichlorophenols, triclosan) in spot urine samples collected during pregnancy among EDEN cohort mothers who delivered a boy. Mothers completed the Strength and Difficulties Questionnaire (SDQ) when their children were 3.1 (n=529) and 5.6 (n=464) y old.

RESULTS

BPA was positively associated with the relationship problems subscale at 3 y [incidence rate ratio (IRR): 1.11; 95% confidence interval (CI): 1.03, 1.20] and the hyperactivity-inattention subscale scores at 5 y (IRR: 1.08; 95% CI: 1.01, 1.14). Mono-n-butyl phthalate (MnBP) was positively associated with internalizing behavior, relationship problem, and emotional symptom scores at 3 y. Monobenzyl phthalate (MBzP) was positively associated with internalizing behavior and relationship problems scores at 3 y. After dichotomizing SDQ scores, triclosan tended to be positively associated with emotional symptom subscales at both 3 and 5 y.

CONCLUSIONS

The observed associations between BPA, MnBP, and behavior in boys are consistent with previous findings. Further health impact assessment studies based on dose-response functions corrected for exposure misclassification are required to quantify the public health burden possibly entailed by such associations. https://doi.org/10.1289/EHP1314.

Authors+Show Affiliations

Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, University Grenoble Alpes , Grenoble, France.Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, University Grenoble Alpes , Grenoble, France.Centers for Disease Control and Prevention , Atlanta, Georgia, USA.U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Research Centre (CRESS) , Early Origin of the Child's Health and Development (ORCHAD) Team, Inserm, Villejuif, France. Université Paris Descartes , Villejuif, France. Faculty of Pharmacy, Université Paris-Sud, Université Paris-Saclay , Châtenay-Malabry, France.U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Research Centre (CRESS) , Early Origin of the Child's Health and Development (ORCHAD) Team, Inserm, Villejuif, France. Université Paris Descartes , Villejuif, France.U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Research Centre (CRESS) , Early Origin of the Child's Health and Development (ORCHAD) Team, Inserm, Villejuif, France. Université Paris Descartes , Villejuif, France.Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, University Grenoble Alpes , Grenoble, France.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28937960

Citation

Philippat, Claire, et al. "Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years." Environmental Health Perspectives, vol. 125, no. 9, 2017, p. 097014.
Philippat C, Nakiwala D, Calafat AM, et al. Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years. Environ Health Perspect. 2017;125(9):097014.
Philippat, C., Nakiwala, D., Calafat, A. M., Botton, J., De Agostini, M., Heude, B., & Slama, R. (2017). Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years. Environmental Health Perspectives, 125(9), 097014. https://doi.org/10.1289/EHP1314
Philippat C, et al. Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years. Environ Health Perspect. 2017 09 15;125(9):097014. PubMed PMID: 28937960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years. AU - Philippat,Claire, AU - Nakiwala,Dorothy, AU - Calafat,Antonia M, AU - Botton,Jérémie, AU - De Agostini,Maria, AU - Heude,Barbara, AU - Slama,Rémy, AU - ,, Y1 - 2017/09/15/ PY - 2016/11/02/received PY - 2017/05/23/revised PY - 2017/06/19/accepted PY - 2017/9/23/entrez PY - 2017/9/25/pubmed PY - 2017/10/28/medline SP - 097014 EP - 097014 JF - Environmental health perspectives JO - Environ Health Perspect VL - 125 IS - 9 N2 - BACKGROUND: Sex-specific associations have been reported between phthalates, bisphenol A (BPA), and child behavior. No data on large study populations are available for other phenols with possible endocrine-disrupting properties. OBJECTIVES: We aimed to study associations between prenatal exposure to phthalates and several phenols on behavior among male infants. METHODS: We quantified 11 phthalate metabolites and nine phenols (four parabens, benzophenone-3, BPA, two dichlorophenols, triclosan) in spot urine samples collected during pregnancy among EDEN cohort mothers who delivered a boy. Mothers completed the Strength and Difficulties Questionnaire (SDQ) when their children were 3.1 (n=529) and 5.6 (n=464) y old. RESULTS: BPA was positively associated with the relationship problems subscale at 3 y [incidence rate ratio (IRR): 1.11; 95% confidence interval (CI): 1.03, 1.20] and the hyperactivity-inattention subscale scores at 5 y (IRR: 1.08; 95% CI: 1.01, 1.14). Mono-n-butyl phthalate (MnBP) was positively associated with internalizing behavior, relationship problem, and emotional symptom scores at 3 y. Monobenzyl phthalate (MBzP) was positively associated with internalizing behavior and relationship problems scores at 3 y. After dichotomizing SDQ scores, triclosan tended to be positively associated with emotional symptom subscales at both 3 and 5 y. CONCLUSIONS: The observed associations between BPA, MnBP, and behavior in boys are consistent with previous findings. Further health impact assessment studies based on dose-response functions corrected for exposure misclassification are required to quantify the public health burden possibly entailed by such associations. https://doi.org/10.1289/EHP1314. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/28937960/Prenatal_Exposure_to_Nonpersistent_Endocrine_Disruptors_and_Behavior_in_Boys_at_3_and_5_Years_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/EHP1314?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -