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Clinicopathologic significance of in vivo antinuclear autoantibodies in oral mucosal biopsies.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Nov; 124(5):475-482.OS

Abstract

OBJECTIVE

Although antinuclear autoantibody (ANA) staining of oral biopsy specimens is indicative of chronic ulcerative stomatitis, it is not known whether this staining is characteristic of other autoimmune diseases. Our study was undertaken to characterize the various in vivo ANA patterns detected in the oral mucosa by direct immunofluorescence to describe the associated hematoxylin and eosin findings, and determine whether patients with these findings had a coexisting systemic connective tissue disease.

STUDY DESIGN

This was a retrospective analysis of oral biopsy specimens submitted from 2013 to 2016.

RESULTS

In vivo ANA staining was present in 72 of the 2019 cases examined. Immunoglobulin G was the most common immunoreactant (71 of 72 cases), and speckled nuclear staining was the most frequent in vivo ANA pattern (52 of 72). In most cases, hematoxylin and eosin staining of biopsy specimens showed mucositis (24 of 34). Detailed clinical information was available for 10 patients, and all of them had an autoimmune disease.

CONCLUSIONS

We found similar prevalence of ANA staining with direct immunofluorescence in oral epithelial biopsy specimens as reported for those of skin. In vivo ANA in the oral epithelium may indicate the presence of an immune-mediated disease. Patients who show ANA deposits in oral mucosal biopsy specimens should be investigated for systemic connective tissue disease as well as for chronic ulcerative stomatitis.

Authors+Show Affiliations

Department of Oral Diagnostics Sciences, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY, USA.Department of Oral Diagnostics Sciences, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY, USA; Immco Diagnostics Inc., Buffalo, NY, USA.Department of Oral Diagnostics Sciences, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY, USA; Immco Diagnostics Inc., Buffalo, NY, USA; Department of Oral Biology, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY, USA.Department of Oral Diagnostics Sciences, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY, USA; Immco Diagnostics Inc., Buffalo, NY, USA. Electronic address: Lsuresh@immco.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28939244

Citation

Alshagroud, Rana, et al. "Clinicopathologic Significance of in Vivo Antinuclear Autoantibodies in Oral Mucosal Biopsies." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 124, no. 5, 2017, pp. 475-482.
Alshagroud R, Neiders M, Kramer JM, et al. Clinicopathologic significance of in vivo antinuclear autoantibodies in oral mucosal biopsies. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124(5):475-482.
Alshagroud, R., Neiders, M., Kramer, J. M., & Suresh, L. (2017). Clinicopathologic significance of in vivo antinuclear autoantibodies in oral mucosal biopsies. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 124(5), 475-482. https://doi.org/10.1016/j.oooo.2017.08.008
Alshagroud R, et al. Clinicopathologic Significance of in Vivo Antinuclear Autoantibodies in Oral Mucosal Biopsies. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124(5):475-482. PubMed PMID: 28939244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathologic significance of in vivo antinuclear autoantibodies in oral mucosal biopsies. AU - Alshagroud,Rana, AU - Neiders,Mirdza, AU - Kramer,Jill M, AU - Suresh,Lakshmanan, Y1 - 2017/08/24/ PY - 2017/06/09/received PY - 2017/08/08/revised PY - 2017/08/10/accepted PY - 2017/9/25/pubmed PY - 2018/4/14/medline PY - 2017/9/24/entrez SP - 475 EP - 482 JF - Oral surgery, oral medicine, oral pathology and oral radiology JO - Oral Surg Oral Med Oral Pathol Oral Radiol VL - 124 IS - 5 N2 - OBJECTIVE: Although antinuclear autoantibody (ANA) staining of oral biopsy specimens is indicative of chronic ulcerative stomatitis, it is not known whether this staining is characteristic of other autoimmune diseases. Our study was undertaken to characterize the various in vivo ANA patterns detected in the oral mucosa by direct immunofluorescence to describe the associated hematoxylin and eosin findings, and determine whether patients with these findings had a coexisting systemic connective tissue disease. STUDY DESIGN: This was a retrospective analysis of oral biopsy specimens submitted from 2013 to 2016. RESULTS: In vivo ANA staining was present in 72 of the 2019 cases examined. Immunoglobulin G was the most common immunoreactant (71 of 72 cases), and speckled nuclear staining was the most frequent in vivo ANA pattern (52 of 72). In most cases, hematoxylin and eosin staining of biopsy specimens showed mucositis (24 of 34). Detailed clinical information was available for 10 patients, and all of them had an autoimmune disease. CONCLUSIONS: We found similar prevalence of ANA staining with direct immunofluorescence in oral epithelial biopsy specimens as reported for those of skin. In vivo ANA in the oral epithelium may indicate the presence of an immune-mediated disease. Patients who show ANA deposits in oral mucosal biopsy specimens should be investigated for systemic connective tissue disease as well as for chronic ulcerative stomatitis. SN - 2212-4411 UR - https://www.unboundmedicine.com/medline/citation/28939244/Clinicopathologic_significance_of_in_vivo_antinuclear_autoantibodies_in_oral_mucosal_biopsies L2 - https://linkinghub.elsevier.com/retrieve/pii/S2212-4403(17)31025-8 DB - PRIME DP - Unbound Medicine ER -