Tags

Type your tag names separated by a space and hit enter

Mesenchymal stromal cells ameliorate acute allergic rhinitis in rats.
Cell Biochem Funct 2017; 35(7):420-425CB

Abstract

Mesenchymal stromal cells (MSCs) have been extensively investigated as a potential antiinflammatory treatment in many inflammatory-related diseases; however, it remains unclear whether MSCs could be used to treat acute allergic rhinitis. A rat model of allergic rhinitis was treated with MSCs. The effect of MSCs on the inflammation of allergic rhinitis was evaluated by sneezing, nose rubbing, the pathology of the nasal mucosa, and the expression of interleukin 4, tumour necrosis factor alpha, and immunoglobulin E in the serum of rats. Also, the population of MSCs isolated from umbilical cords of humans was evaluated to determine if they could inhibit the symptoms and inflammation of acute allergic rhinitis in a rat model. We observed that this population of cells inhibited sneezing, nose rubbing, and changes in the pathology of the nasal mucosa. Intriguingly, we observed that MSCs reduced the expression of interleukin 4, tumour necrosis factor alpha, and immunoglobulin E in the serum. Furthermore, MSCs reduced the expression of histamine and the recruitment of macrophages in the nasal mucosa of allergic rhinitis rats. We reasoned that the effect of MSCs on allergic rhinitis might be through its regulation of the secretion of related cytokines from macrophages during the process of acute allergic rhinitis. This work suggested that MSCs from the umbilical cords of humans could be used as a positive clinical therapy for the human disease.

Authors+Show Affiliations

Graduate School of Beijing University of Chinese Medicine, Clinical Medical School of Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. National Clinical Research Center of Respiratory Diseases, Center for Respiratory Diseases China-Japan Friendship Hospital, The 2nd Pulmonary Department of TCM, The Key Institute of State Administration of Traditional Chinese Medicine (Pneumonopathy Chronic Cough and Dyspnea), Beijing Key Laboratory (no BZ0321), China-Japan Friendship Hospital, Beijing, China.State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.National Clinical Research Center of Respiratory Diseases, Center for Respiratory Diseases China-Japan Friendship Hospital, The 2nd Pulmonary Department of TCM, The Key Institute of State Administration of Traditional Chinese Medicine (Pneumonopathy Chronic Cough and Dyspnea), Beijing Key Laboratory (no BZ0321), China-Japan Friendship Hospital, Beijing, China.State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.Institute of Immunology, Medical School, Third Military Medical University, Chongqing, China.State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28940415

Citation

Li, Chunlei, et al. "Mesenchymal Stromal Cells Ameliorate Acute Allergic Rhinitis in Rats." Cell Biochemistry and Function, vol. 35, no. 7, 2017, pp. 420-425.
Li C, Fu Y, Wang Y, et al. Mesenchymal stromal cells ameliorate acute allergic rhinitis in rats. Cell Biochem Funct. 2017;35(7):420-425.
Li, C., Fu, Y., Wang, Y., Kong, Y., Li, M., Ma, D., ... Wang, Y. (2017). Mesenchymal stromal cells ameliorate acute allergic rhinitis in rats. Cell Biochemistry and Function, 35(7), pp. 420-425. doi:10.1002/cbf.3291.
Li C, et al. Mesenchymal Stromal Cells Ameliorate Acute Allergic Rhinitis in Rats. Cell Biochem Funct. 2017;35(7):420-425. PubMed PMID: 28940415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mesenchymal stromal cells ameliorate acute allergic rhinitis in rats. AU - Li,Chunlei, AU - Fu,Yanxia, AU - Wang,Yinyin, AU - Kong,Yanhua, AU - Li,Mengdi, AU - Ma,Danhui, AU - Zhai,Wanli, AU - Wang,Hao, AU - Lin,Yuting, AU - Liu,Sihan, AU - Ren,Fangli, AU - Li,Jun, AU - Wang,Yi, Y1 - 2017/09/20/ PY - 2017/07/11/received PY - 2017/07/13/accepted PY - 2017/9/25/pubmed PY - 2017/11/29/medline PY - 2017/9/24/entrez KW - allergic rhinitis KW - antiinflammation KW - cytokine KW - mesenchymal stromal cells KW - umbilical cord SP - 420 EP - 425 JF - Cell biochemistry and function JO - Cell Biochem. Funct. VL - 35 IS - 7 N2 - Mesenchymal stromal cells (MSCs) have been extensively investigated as a potential antiinflammatory treatment in many inflammatory-related diseases; however, it remains unclear whether MSCs could be used to treat acute allergic rhinitis. A rat model of allergic rhinitis was treated with MSCs. The effect of MSCs on the inflammation of allergic rhinitis was evaluated by sneezing, nose rubbing, the pathology of the nasal mucosa, and the expression of interleukin 4, tumour necrosis factor alpha, and immunoglobulin E in the serum of rats. Also, the population of MSCs isolated from umbilical cords of humans was evaluated to determine if they could inhibit the symptoms and inflammation of acute allergic rhinitis in a rat model. We observed that this population of cells inhibited sneezing, nose rubbing, and changes in the pathology of the nasal mucosa. Intriguingly, we observed that MSCs reduced the expression of interleukin 4, tumour necrosis factor alpha, and immunoglobulin E in the serum. Furthermore, MSCs reduced the expression of histamine and the recruitment of macrophages in the nasal mucosa of allergic rhinitis rats. We reasoned that the effect of MSCs on allergic rhinitis might be through its regulation of the secretion of related cytokines from macrophages during the process of acute allergic rhinitis. This work suggested that MSCs from the umbilical cords of humans could be used as a positive clinical therapy for the human disease. SN - 1099-0844 UR - https://www.unboundmedicine.com/medline/citation/28940415/Mesenchymal_stromal_cells_ameliorate_acute_allergic_rhinitis_in_rats L2 - https://doi.org/10.1002/cbf.3291 DB - PRIME DP - Unbound Medicine ER -