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Prevalence of dermatologic manifestations and metabolic biomarkers in women with polycystic ovary syndrome in north China.
J Cosmet Dermatol. 2018 Jun; 17(3):511-517.JC

Abstract

BACKGROUND

Cutaneous features of hyperandrogenism in polycystic ovary syndrome (PCOS) include acne, hirsutism, seborrhea, androgenic alopecia (AGA), and acanthosis nigricans (AN). However, the relationships have not been well known broadly in terms of clinical hyperandrogenism and biochemical markers.

OBJECTIVES

The aim of this study was to investigate biochemical and metabolic parameters in relation to cutaneous characters women in with and without PCOS.

METHODS

This was a cross-sectional retrospective study including 186 women with PCOS and 113 age-matched without PCOS women. Acne grade, hirsutism, seborrhea, AGA, and AN were recorded. Hormonal and metabolic parameters were measured.

RESULTS

The most common finding was acne, and AN was the least dermatological manifestations between PCOS and non-PCOS groups. The severity location and type of acne did not differ in PCOS women compared to non-PCOS women. Significant differences were found with respect to free androgen index (FAI) (P = .036), sex hormone-binding globulin (SHBG) (P = .023), and body mass index (BMI) (P = .001) between PCOS with acne and PCOS without acne groups. Overall, age (P = .005) was significantly decreased, while BMI (P = .004) was significantly higher in PCOS with hirsutism. The mean serum total testosterone (TT), dehydroepiandrosterone sulfate, and FAI were significantly elevated, but SHBG was decreased between PCOS with and without hirsutism groups. There were significantly different BMI (P = .018) and triglyceride (P = .024) except other hormonal parameter of without AGA group.

CONCLUSION

This study indicated a strong correlation between hirsutism and metabolic abnormalities. Hirsutism is the most common cutaneous finding in PCOS women. Acne and AGA are associated with other manifestations of clinical hyperandrogenism, but not obvious markers of biochemical hyperandrogenemia and metabolic dysfunction.

Authors+Show Affiliations

Department of Dermatology, Fu Xing Hospital of Capital Medical University, Beijing, China.Department of Obstetrics and Gynecology, Fu Xing Hospital of Capital Medical University, Beijing, China.Department of Physical Examination, Primary and Middle School Health Care Institute of Xuan wu District, Beijing, China.Department of Ultrasonography, Fu Xing Hospital of Capital Medical University, Beijing, China.Department of Dermatology, Xuan Wu Hospital Capital Medical University, Beijing, China.Department of Dermatology, Xuan Wu Hospital Capital Medical University, Beijing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28940857

Citation

Feng, Jin-Ge, et al. "Prevalence of Dermatologic Manifestations and Metabolic Biomarkers in Women With Polycystic Ovary Syndrome in North China." Journal of Cosmetic Dermatology, vol. 17, no. 3, 2018, pp. 511-517.
Feng JG, Guo Y, Ma LA, et al. Prevalence of dermatologic manifestations and metabolic biomarkers in women with polycystic ovary syndrome in north China. J Cosmet Dermatol. 2018;17(3):511-517.
Feng, J. G., Guo, Y., Ma, L. A., Xing, J., Sun, R. F., & Zhu, W. (2018). Prevalence of dermatologic manifestations and metabolic biomarkers in women with polycystic ovary syndrome in north China. Journal of Cosmetic Dermatology, 17(3), 511-517. https://doi.org/10.1111/jocd.12387
Feng JG, et al. Prevalence of Dermatologic Manifestations and Metabolic Biomarkers in Women With Polycystic Ovary Syndrome in North China. J Cosmet Dermatol. 2018;17(3):511-517. PubMed PMID: 28940857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of dermatologic manifestations and metabolic biomarkers in women with polycystic ovary syndrome in north China. AU - Feng,Jin-Ge, AU - Guo,Yan, AU - Ma,Li-Ang, AU - Xing,Jin, AU - Sun,Rui-Feng, AU - Zhu,Wei, Y1 - 2017/09/21/ PY - 2017/07/09/accepted PY - 2017/9/25/pubmed PY - 2018/11/14/medline PY - 2017/9/24/entrez KW - acne KW - androgenic alopecia KW - hirsutism KW - hyperandrogenism KW - metabolic biomarker KW - polycystic ovary syndrome SP - 511 EP - 517 JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol VL - 17 IS - 3 N2 - BACKGROUND: Cutaneous features of hyperandrogenism in polycystic ovary syndrome (PCOS) include acne, hirsutism, seborrhea, androgenic alopecia (AGA), and acanthosis nigricans (AN). However, the relationships have not been well known broadly in terms of clinical hyperandrogenism and biochemical markers. OBJECTIVES: The aim of this study was to investigate biochemical and metabolic parameters in relation to cutaneous characters women in with and without PCOS. METHODS: This was a cross-sectional retrospective study including 186 women with PCOS and 113 age-matched without PCOS women. Acne grade, hirsutism, seborrhea, AGA, and AN were recorded. Hormonal and metabolic parameters were measured. RESULTS: The most common finding was acne, and AN was the least dermatological manifestations between PCOS and non-PCOS groups. The severity location and type of acne did not differ in PCOS women compared to non-PCOS women. Significant differences were found with respect to free androgen index (FAI) (P = .036), sex hormone-binding globulin (SHBG) (P = .023), and body mass index (BMI) (P = .001) between PCOS with acne and PCOS without acne groups. Overall, age (P = .005) was significantly decreased, while BMI (P = .004) was significantly higher in PCOS with hirsutism. The mean serum total testosterone (TT), dehydroepiandrosterone sulfate, and FAI were significantly elevated, but SHBG was decreased between PCOS with and without hirsutism groups. There were significantly different BMI (P = .018) and triglyceride (P = .024) except other hormonal parameter of without AGA group. CONCLUSION: This study indicated a strong correlation between hirsutism and metabolic abnormalities. Hirsutism is the most common cutaneous finding in PCOS women. Acne and AGA are associated with other manifestations of clinical hyperandrogenism, but not obvious markers of biochemical hyperandrogenemia and metabolic dysfunction. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/28940857/Prevalence_of_dermatologic_manifestations_and_metabolic_biomarkers_in_women_with_polycystic_ovary_syndrome_in_north_China_ L2 - https://doi.org/10.1111/jocd.12387 DB - PRIME DP - Unbound Medicine ER -