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The course of infection caused by Encephalitozoon cuniculi genotype III in immunocompetent and immunodeficient mice.
Exp Parasitol. 2017 Nov; 182:16-21.EP

Abstract

Encephalitozoon cuniculi is probably the most common microsporidia which infects a wide range of vertebrates, including human. So far, four genotypes of this parasite have been identified based on the rRNA internal transcribed spacer variations. The course of infection caused by E. cuniculi III had very massive onset in immunocompetent host characterized by the presence of this parasite in all organs and tissues within one week after peroral infection. Encephalitozoonosis caused by E. cuniculi III had very progressive spreading into all organs within first week post inoculation in immunocompromised SCID mice and led to the death of the host. The experimental treatment with albendazole of immunocompetent BALB/c mice infected with E. cuniculi III have shown very weak effect. Our findings clearly showed that the different course of infection and response to treatment depends not only on the immunological status of the host, but also on the genotype of microsporidia. It could be very important especially for individuals under chemotherapy and transplant recipients of organs originating from infected donors.

Authors+Show Affiliations

Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic; Faculty of Agriculture, University of South Bohemia in České Budějovice, České Budějovice, Czech Republic.Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic. Electronic address: casio@paru.cas.cz.Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic; Faculty of Agriculture, University of South Bohemia in České Budějovice, České Budějovice, Czech Republic.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28942047

Citation

Kotková, Michaela, et al. "The Course of Infection Caused By Encephalitozoon Cuniculi Genotype III in Immunocompetent and Immunodeficient Mice." Experimental Parasitology, vol. 182, 2017, pp. 16-21.
Kotková M, Sak B, Hlásková L, et al. The course of infection caused by Encephalitozoon cuniculi genotype III in immunocompetent and immunodeficient mice. Exp Parasitol. 2017;182:16-21.
Kotková, M., Sak, B., Hlásková, L., & Kváč, M. (2017). The course of infection caused by Encephalitozoon cuniculi genotype III in immunocompetent and immunodeficient mice. Experimental Parasitology, 182, 16-21. https://doi.org/10.1016/j.exppara.2017.09.022
Kotková M, et al. The Course of Infection Caused By Encephalitozoon Cuniculi Genotype III in Immunocompetent and Immunodeficient Mice. Exp Parasitol. 2017;182:16-21. PubMed PMID: 28942047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The course of infection caused by Encephalitozoon cuniculi genotype III in immunocompetent and immunodeficient mice. AU - Kotková,Michaela, AU - Sak,Bohumil, AU - Hlásková,Lenka, AU - Kváč,Martin, Y1 - 2017/09/21/ PY - 2017/06/06/received PY - 2017/09/01/revised PY - 2017/09/17/accepted PY - 2017/9/25/pubmed PY - 2017/11/1/medline PY - 2017/9/25/entrez KW - Albendazole KW - BALB/C KW - Encephalitozoon cuniculi genotypes II and III KW - Microsporidiosis KW - SCID SP - 16 EP - 21 JF - Experimental parasitology JO - Exp. Parasitol. VL - 182 N2 - Encephalitozoon cuniculi is probably the most common microsporidia which infects a wide range of vertebrates, including human. So far, four genotypes of this parasite have been identified based on the rRNA internal transcribed spacer variations. The course of infection caused by E. cuniculi III had very massive onset in immunocompetent host characterized by the presence of this parasite in all organs and tissues within one week after peroral infection. Encephalitozoonosis caused by E. cuniculi III had very progressive spreading into all organs within first week post inoculation in immunocompromised SCID mice and led to the death of the host. The experimental treatment with albendazole of immunocompetent BALB/c mice infected with E. cuniculi III have shown very weak effect. Our findings clearly showed that the different course of infection and response to treatment depends not only on the immunological status of the host, but also on the genotype of microsporidia. It could be very important especially for individuals under chemotherapy and transplant recipients of organs originating from infected donors. SN - 1090-2449 UR - https://www.unboundmedicine.com/medline/citation/28942047/The_course_of_infection_caused_by_Encephalitozoon_cuniculi_genotype_III_in_immunocompetent_and_immunodeficient_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4894(17)30308-9 DB - PRIME DP - Unbound Medicine ER -