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Regional fat loss from the thigh in obese women after adrenergic modulation.

Abstract

Beta-adrenergic stimulation and alpha 2-adrenergic inhibition increase lipolysis from fat cells. Twenty-eight obese women were placed on a calorie-restricted diet and one of five treatments was applied to one thigh three to five times per week for four weeks: (1) isoproterenol injections; (2) cream containing colforsin (forskolin), aminophylline, and yohimbine; (3) yohimbine cream; (4) colforsin cream; or (5) aminophylline cream. The opposite thigh was treated with a placebo (injection or cream). The treated thighs lost significantly more girth after treatment, both by injection and by cream. No adverse reactions were attributable to either the cream or the injections. It is concluded that local fat reduction from the thigh can be safely accomplished.

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Authors+Show Affiliations

,

Department of Medicine, UCLA School of Medicine.

Source

Clinical therapeutics 9:6 1987 pg 663-9

MeSH

Adipose Tissue
Administration, Cutaneous
Adrenergic alpha-Antagonists
Adrenergic beta-Agonists
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Injections
Lipolysis
Obesity
Phosphodiesterase Inhibitors
Thigh

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

2894247