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Regional fat loss from the thigh in obese women after adrenergic modulation.

Abstract

Beta-adrenergic stimulation and alpha 2-adrenergic inhibition increase lipolysis from fat cells. Twenty-eight obese women were placed on a calorie-restricted diet and one of five treatments was applied to one thigh three to five times per week for four weeks: (1) isoproterenol injections; (2) cream containing colforsin (forskolin), aminophylline, and yohimbine; (3) yohimbine cream; (4) colforsin cream; or (5) aminophylline cream. The opposite thigh was treated with a placebo (injection or cream). The treated thighs lost significantly more girth after treatment, both by injection and by cream. No adverse reactions were attributable to either the cream or the injections. It is concluded that local fat reduction from the thigh can be safely accomplished.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, UCLA School of Medicine.

    Source

    Clinical therapeutics 9:6 1987 pg 663-9

    MeSH

    Adipose Tissue
    Administration, Cutaneous
    Adrenergic alpha-Antagonists
    Adrenergic beta-Agonists
    Clinical Trials as Topic
    Double-Blind Method
    Female
    Humans
    Injections
    Lipolysis
    Obesity
    Phosphodiesterase Inhibitors
    Thigh

    Pub Type(s)

    Clinical Trial
    Controlled Clinical Trial
    Journal Article

    Language

    eng

    PubMed ID

    2894247

    Citation

    Greenway, F L., and G A. Bray. "Regional Fat Loss From the Thigh in Obese Women After Adrenergic Modulation." Clinical Therapeutics, vol. 9, no. 6, 1987, pp. 663-9.
    Greenway FL, Bray GA. Regional fat loss from the thigh in obese women after adrenergic modulation. Clin Ther. 1987;9(6):663-9.
    Greenway, F. L., & Bray, G. A. (1987). Regional fat loss from the thigh in obese women after adrenergic modulation. Clinical Therapeutics, 9(6), pp. 663-9.
    Greenway FL, Bray GA. Regional Fat Loss From the Thigh in Obese Women After Adrenergic Modulation. Clin Ther. 1987;9(6):663-9. PubMed PMID: 2894247.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Regional fat loss from the thigh in obese women after adrenergic modulation. AU - Greenway,F L, AU - Bray,G A, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 663 EP - 9 JF - Clinical therapeutics JO - Clin Ther VL - 9 IS - 6 N2 - Beta-adrenergic stimulation and alpha 2-adrenergic inhibition increase lipolysis from fat cells. Twenty-eight obese women were placed on a calorie-restricted diet and one of five treatments was applied to one thigh three to five times per week for four weeks: (1) isoproterenol injections; (2) cream containing colforsin (forskolin), aminophylline, and yohimbine; (3) yohimbine cream; (4) colforsin cream; or (5) aminophylline cream. The opposite thigh was treated with a placebo (injection or cream). The treated thighs lost significantly more girth after treatment, both by injection and by cream. No adverse reactions were attributable to either the cream or the injections. It is concluded that local fat reduction from the thigh can be safely accomplished. SN - 0149-2918 UR - https://www.unboundmedicine.com/medline/citation/2894247/abstract/Regional_fat_loss_from_the_thigh_in_obese_women_after_adrenergic_modulation_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -