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Aetiological association of a virus-like particle with enterically transmitted non-A, non-B hepatitis.

Abstract

Virus-like particles, approximately 27 nm in diameter, were identified in faeces from an Indian patient with enterically transmitted non-A, non-B (ENANB) hepatitis. They were serologically distinct from hepatitis A virus (HAV). Nucleic acid extracted from the particles did not hybridize with cDNA probes representing the genomes of HAV, enteroviruses, and cardioviruses. Chimpanzees were experimentally inoculated with faecal suspensions containing this 27 nm particle or with faeces from another case of ENANB hepatitis. Mild histological and biochemical hepatitis developed in these animals and there was serological evidence of infection with the virus-like particle as shown by immunoelectronmicroscopy (IEM). Serological analysis by IEM suggested that this agent or an antigenically similar virus was the aetiological agent of two epidemics and a sporadic case of ENANB hepatitis in India and of an epidemic of the illness in the USSR. Antibody to the particle was found in sera from patients with ENANB hepatitis from various geographic areas over a 30-year period.

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  • Authors+Show Affiliations

    ,

    National Institute of Virology, Pune, India.

    , , , , ,

    Source

    Lancet (London, England) 1:8585 1988 Mar 12 pg 550-4

    MeSH

    Animals
    Cells, Cultured
    Cytopathogenic Effect, Viral
    Disease Outbreaks
    Feces
    Hepatitis Antibodies
    Hepatitis C
    Hepatitis Viruses
    Hepatitis, Viral, Human
    Humans
    Hybridization, Genetic
    Immunologic Techniques
    India
    Liver
    Mice
    Microscopy, Electron
    Pan troglodytes
    USSR

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    2894491

    Citation

    Arankalle, V A., et al. "Aetiological Association of a Virus-like Particle With Enterically Transmitted non-A, non-B Hepatitis." Lancet (London, England), vol. 1, no. 8585, 1988, pp. 550-4.
    Arankalle VA, Ticehurst J, Sreenivasan MA, et al. Aetiological association of a virus-like particle with enterically transmitted non-A, non-B hepatitis. Lancet. 1988;1(8585):550-4.
    Arankalle, V. A., Ticehurst, J., Sreenivasan, M. A., Kapikian, A. Z., Popper, H., Pavri, K. M., & Purcell, R. H. (1988). Aetiological association of a virus-like particle with enterically transmitted non-A, non-B hepatitis. Lancet (London, England), 1(8585), pp. 550-4.
    Arankalle VA, et al. Aetiological Association of a Virus-like Particle With Enterically Transmitted non-A, non-B Hepatitis. Lancet. 1988 Mar 12;1(8585):550-4. PubMed PMID: 2894491.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Aetiological association of a virus-like particle with enterically transmitted non-A, non-B hepatitis. AU - Arankalle,V A, AU - Ticehurst,J, AU - Sreenivasan,M A, AU - Kapikian,A Z, AU - Popper,H, AU - Pavri,K M, AU - Purcell,R H, PY - 1988/3/12/pubmed PY - 1988/3/12/medline PY - 1988/3/12/entrez SP - 550 EP - 4 JF - Lancet (London, England) JO - Lancet VL - 1 IS - 8585 N2 - Virus-like particles, approximately 27 nm in diameter, were identified in faeces from an Indian patient with enterically transmitted non-A, non-B (ENANB) hepatitis. They were serologically distinct from hepatitis A virus (HAV). Nucleic acid extracted from the particles did not hybridize with cDNA probes representing the genomes of HAV, enteroviruses, and cardioviruses. Chimpanzees were experimentally inoculated with faecal suspensions containing this 27 nm particle or with faeces from another case of ENANB hepatitis. Mild histological and biochemical hepatitis developed in these animals and there was serological evidence of infection with the virus-like particle as shown by immunoelectronmicroscopy (IEM). Serological analysis by IEM suggested that this agent or an antigenically similar virus was the aetiological agent of two epidemics and a sporadic case of ENANB hepatitis in India and of an epidemic of the illness in the USSR. Antibody to the particle was found in sera from patients with ENANB hepatitis from various geographic areas over a 30-year period. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/2894491/Aetiological_association_of_a_virus_like_particle_with_enterically_transmitted_non_A_non_B_hepatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(88)91351-7 DB - PRIME DP - Unbound Medicine ER -