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Aetiological association of a virus-like particle with enterically transmitted non-A, non-B hepatitis.
Lancet 1988; 1(8585):550-4Lct

Abstract

Virus-like particles, approximately 27 nm in diameter, were identified in faeces from an Indian patient with enterically transmitted non-A, non-B (ENANB) hepatitis. They were serologically distinct from hepatitis A virus (HAV). Nucleic acid extracted from the particles did not hybridize with cDNA probes representing the genomes of HAV, enteroviruses, and cardioviruses. Chimpanzees were experimentally inoculated with faecal suspensions containing this 27 nm particle or with faeces from another case of ENANB hepatitis. Mild histological and biochemical hepatitis developed in these animals and there was serological evidence of infection with the virus-like particle as shown by immunoelectronmicroscopy (IEM). Serological analysis by IEM suggested that this agent or an antigenically similar virus was the aetiological agent of two epidemics and a sporadic case of ENANB hepatitis in India and of an epidemic of the illness in the USSR. Antibody to the particle was found in sera from patients with ENANB hepatitis from various geographic areas over a 30-year period.

Authors+Show Affiliations

National Institute of Virology, Pune, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2894491

Citation

Arankalle, V A., et al. "Aetiological Association of a Virus-like Particle With Enterically Transmitted non-A, non-B Hepatitis." Lancet (London, England), vol. 1, no. 8585, 1988, pp. 550-4.
Arankalle VA, Ticehurst J, Sreenivasan MA, et al. Aetiological association of a virus-like particle with enterically transmitted non-A, non-B hepatitis. Lancet. 1988;1(8585):550-4.
Arankalle, V. A., Ticehurst, J., Sreenivasan, M. A., Kapikian, A. Z., Popper, H., Pavri, K. M., & Purcell, R. H. (1988). Aetiological association of a virus-like particle with enterically transmitted non-A, non-B hepatitis. Lancet (London, England), 1(8585), pp. 550-4.
Arankalle VA, et al. Aetiological Association of a Virus-like Particle With Enterically Transmitted non-A, non-B Hepatitis. Lancet. 1988 Mar 12;1(8585):550-4. PubMed PMID: 2894491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aetiological association of a virus-like particle with enterically transmitted non-A, non-B hepatitis. AU - Arankalle,V A, AU - Ticehurst,J, AU - Sreenivasan,M A, AU - Kapikian,A Z, AU - Popper,H, AU - Pavri,K M, AU - Purcell,R H, PY - 1988/3/12/pubmed PY - 1988/3/12/medline PY - 1988/3/12/entrez SP - 550 EP - 4 JF - Lancet (London, England) JO - Lancet VL - 1 IS - 8585 N2 - Virus-like particles, approximately 27 nm in diameter, were identified in faeces from an Indian patient with enterically transmitted non-A, non-B (ENANB) hepatitis. They were serologically distinct from hepatitis A virus (HAV). Nucleic acid extracted from the particles did not hybridize with cDNA probes representing the genomes of HAV, enteroviruses, and cardioviruses. Chimpanzees were experimentally inoculated with faecal suspensions containing this 27 nm particle or with faeces from another case of ENANB hepatitis. Mild histological and biochemical hepatitis developed in these animals and there was serological evidence of infection with the virus-like particle as shown by immunoelectronmicroscopy (IEM). Serological analysis by IEM suggested that this agent or an antigenically similar virus was the aetiological agent of two epidemics and a sporadic case of ENANB hepatitis in India and of an epidemic of the illness in the USSR. Antibody to the particle was found in sera from patients with ENANB hepatitis from various geographic areas over a 30-year period. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/2894491/Aetiological_association_of_a_virus_like_particle_with_enterically_transmitted_non_A_non_B_hepatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(88)91351-7 DB - PRIME DP - Unbound Medicine ER -