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Waterborne non-A, non-B hepatitis.

Abstract

Waterborne non-A, non-B hepatitis (NANB) is responsible for outbreaks of hepatitis with a predilection for young adults. The disease is usually mild, except in pregnant women, who have a high case-fatality rate from fulminant hepatic failure. Diagnosis is largely based on the epidemiological findings of faecal contamination of drinking water and serological exclusion of hepatitis A and B virus infection. Histological features of liver biopsy specimens are characteristic and virus-like particles in the stool are aggregated by antibody present in acute and convalescent phase sera of the test subject. NANB is widespread in India and several countries of South-East Asia; it is increasingly recognised in Africa and may occur in Latin America. Control measures include provision of clean water supplies, safe disposal of human excreta, and sound personal and food hygiene practices. Passive immunisation with immunoglobulin derived from healthy donors resident in the countries affected by the disease may protect vulnerable groups.

Authors+Show Affiliations

,

Fogarty International Center, National Institutes of Health, Bethesda, Maryland.

Source

Lancet (London, England) 1:8585 1988 Mar 12 pg 571-3

MeSH

Adolescent
Adult
Africa
Asia, Central
Disease Outbreaks
Feces
Female
Hepatitis C
Hepatitis Viruses
Hepatitis, Viral, Human
Humans
Hygiene
Immunization, Passive
India
Indonesia
Male
Myanmar
Nepal
Pregnancy
Thailand
Water Pollution
Water Supply

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2894501

Citation

Ramalingaswami, V, and R H. Purcell. "Waterborne non-A, non-B Hepatitis." Lancet (London, England), vol. 1, no. 8585, 1988, pp. 571-3.
Ramalingaswami V, Purcell RH. Waterborne non-A, non-B hepatitis. Lancet. 1988;1(8585):571-3.
Ramalingaswami, V., & Purcell, R. H. (1988). Waterborne non-A, non-B hepatitis. Lancet (London, England), 1(8585), pp. 571-3.
Ramalingaswami V, Purcell RH. Waterborne non-A, non-B Hepatitis. Lancet. 1988 Mar 12;1(8585):571-3. PubMed PMID: 2894501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Waterborne non-A, non-B hepatitis. AU - Ramalingaswami,V, AU - Purcell,R H, PY - 1988/3/12/pubmed PY - 1988/3/12/medline PY - 1988/3/12/entrez SP - 571 EP - 3 JF - Lancet (London, England) JO - Lancet VL - 1 IS - 8585 N2 - Waterborne non-A, non-B hepatitis (NANB) is responsible for outbreaks of hepatitis with a predilection for young adults. The disease is usually mild, except in pregnant women, who have a high case-fatality rate from fulminant hepatic failure. Diagnosis is largely based on the epidemiological findings of faecal contamination of drinking water and serological exclusion of hepatitis A and B virus infection. Histological features of liver biopsy specimens are characteristic and virus-like particles in the stool are aggregated by antibody present in acute and convalescent phase sera of the test subject. NANB is widespread in India and several countries of South-East Asia; it is increasingly recognised in Africa and may occur in Latin America. Control measures include provision of clean water supplies, safe disposal of human excreta, and sound personal and food hygiene practices. Passive immunisation with immunoglobulin derived from healthy donors resident in the countries affected by the disease may protect vulnerable groups. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/2894501/Waterborne_non_A_non_B_hepatitis_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -