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Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum).
Molecules. 2017 Sep 25; 22(10)M

Abstract

Having served as a symbolic fruit since ancient times, pomegranate (Punica granatum) has also gained considerable recognition as a functional food in the modern era. A large body of literature has linked pomegranate polyphenols, particularly anthocyanins (ATs) and hydrolyzable tannins (HTs), to the health-promoting activities of pomegranate juice and fruit extracts. However, it remains unclear as to how, and to what extent, the numerous phytochemicals in pomegranate may interact and exert cooperative activities in humans. In this review, we examine the structural and analytical information of the diverse phytochemicals that have been identified in different pomegranate tissues, to establish a knowledge base for characterization of metabolite profiles, discovery of novel phytochemicals, and investigation of phytochemical interactions in pomegranate. We also assess recent findings on the function and molecular mechanism of ATs as well as urolithins, the intestinal microbial derivatives of pomegranate HTs, on human nutrition and health. A better understanding of the structural diversity of pomegranate phytochemicals as well as their bioconversions and bioactivities in humans will facilitate the interrogation of their synergistic/antagonistic interactions and accelerate their applications in dietary-based cancer chemoprevention and treatment in the future.

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Authors+Show Affiliations

Wu S
Shanghai Key Laboratory of Plant Functional Genomics and Resources, Shanghai Chenshan Botanical Garden, Shanghai 201602, China. wusheng@mail.sioc.ac.cn. Shanghai Chenshan Plant Science Research Center, Chinese Academy of Sciences, Shanghai 201602, China. wusheng@mail.sioc.ac.cn.
Tian L
Shanghai Key Laboratory of Plant Functional Genomics and Resources, Shanghai Chenshan Botanical Garden, Shanghai 201602, China. ltian@ucdavis.edu. Shanghai Chenshan Plant Science Research Center, Chinese Academy of Sciences, Shanghai 201602, China. ltian@ucdavis.edu. Department of Plant Sciences, University of California, Davis, CA 95616, USA. ltian@ucdavis.edu.

MeSH

Ellagic AcidFruitHydrolyzable TanninsLythraceaePhytochemicalsPolyphenols

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28946708

Citation

Wu, Sheng, and Li Tian. "Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica Granatum)." Molecules (Basel, Switzerland), vol. 22, no. 10, 2017.
Wu S, Tian L. Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum). Molecules. 2017;22(10).
Wu, S., & Tian, L. (2017). Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum). Molecules (Basel, Switzerland), 22(10). https://doi.org/10.3390/molecules22101606
Wu S, Tian L. Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica Granatum). Molecules. 2017 Sep 25;22(10) PubMed PMID: 28946708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum). AU - Wu,Sheng, AU - Tian,Li, Y1 - 2017/09/25/ PY - 2017/08/25/received PY - 2017/09/21/revised PY - 2017/09/21/accepted PY - 2017/9/27/entrez PY - 2017/9/28/pubmed PY - 2018/5/22/medline KW - Punica granatum KW - anthocyanin KW - ellagic acid KW - ellagitannin KW - functional food KW - hydrolyzable tannin KW - polyphenol KW - pomegranate KW - urolithin JF - Molecules (Basel, Switzerland) JO - Molecules VL - 22 IS - 10 N2 - Having served as a symbolic fruit since ancient times, pomegranate (Punica granatum) has also gained considerable recognition as a functional food in the modern era. A large body of literature has linked pomegranate polyphenols, particularly anthocyanins (ATs) and hydrolyzable tannins (HTs), to the health-promoting activities of pomegranate juice and fruit extracts. However, it remains unclear as to how, and to what extent, the numerous phytochemicals in pomegranate may interact and exert cooperative activities in humans. In this review, we examine the structural and analytical information of the diverse phytochemicals that have been identified in different pomegranate tissues, to establish a knowledge base for characterization of metabolite profiles, discovery of novel phytochemicals, and investigation of phytochemical interactions in pomegranate. We also assess recent findings on the function and molecular mechanism of ATs as well as urolithins, the intestinal microbial derivatives of pomegranate HTs, on human nutrition and health. A better understanding of the structural diversity of pomegranate phytochemicals as well as their bioconversions and bioactivities in humans will facilitate the interrogation of their synergistic/antagonistic interactions and accelerate their applications in dietary-based cancer chemoprevention and treatment in the future. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/28946708/Diverse_Phytochemicals_and_Bioactivities_in_the_Ancient_Fruit_and_Modern_Functional_Food_Pomegranate__Punica_granatum__ DB - PRIME DP - Unbound Medicine ER -