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Mild cognitive impairment in older adults with pre-dialysis patients with chronic kidney disease: Prevalence and association with physical function.
Nephrology (Carlton). 2019 Jan; 24(1):50-55.N

Abstract

AIM

Chronic kidney disease (CKD) is a risk factor for declining cognitive and physical function. However, the prevalence of mild cognitive impairment (MCI) and its relationship with physical function is not clear. Therefore, our aim was to evaluate the prevalence of MCI and the relationship between MCI and physical function among older adults with pre-dialysis CKD.

METHODS

We conducted a cross-sectional study of 120 patients, aged ≥65 years (mean age, 77.3 years), with pre-dialysis CKD but without probable dementia (Mini Mental State Examination <24). MCI was evaluated using the Japanese version of the Montreal Cognitive Assessment (MoCA-J). For analysis, patients were classified into two cognitive function groups: normal (MoCA-J ≥ 26) and MCI (MoCA-J < 26). Physical, clinical, and biochemical parameters were compared between the groups. Logistic and linear regression analyses were used to evaluate the specific association between cognitive and physical function.

RESULTS

Seventy-five (62.5%) patients belonged to the MCI group. Significant differences between the two groups were identified for gait speed, balance, age, and haemoglobin concentration. After adjustment for covariates, only gait speed was significantly associated with MCI (odds ratio, 0.06; 95% confidence interval, 0.009-0,411).

CONCLUSION

The prevalence of MCI among older adults with pre-dialysis CKD was as high as 62.5%. The association between MCI and reduced gait speed supports the possible interaction between physical and cognitive functions and the need for early screening.

Authors+Show Affiliations

Department of Rehabilitation Medicine, St. Marianna University School of Medicine Hospital, Kawasaki, Japan. Department of Rehabilitation Medicine, Kawasaki Municipal Tama Hospital, Kawasaki, Japan.Department of Rehabilitation Medicine, St. Marianna University School of Medicine Hospital, Kawasaki, Japan.Department of Rehabilitation Medicine, St. Marianna University School of Medicine Hospital, Kawasaki, Japan.Department of Rehabilitation Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Japan.Graduate School of Health Sciences, Kobe University, Kobe, Japan.Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28949427

Citation

Otobe, Yuhei, et al. "Mild Cognitive Impairment in Older Adults With Pre-dialysis Patients With Chronic Kidney Disease: Prevalence and Association With Physical Function." Nephrology (Carlton, Vic.), vol. 24, no. 1, 2019, pp. 50-55.
Otobe Y, Hiraki K, Hotta C, et al. Mild cognitive impairment in older adults with pre-dialysis patients with chronic kidney disease: Prevalence and association with physical function. Nephrology (Carlton). 2019;24(1):50-55.
Otobe, Y., Hiraki, K., Hotta, C., Nishizawa, H., Izawa, K. P., Taki, Y., Imai, N., Sakurada, T., & Shibagaki, Y. (2019). Mild cognitive impairment in older adults with pre-dialysis patients with chronic kidney disease: Prevalence and association with physical function. Nephrology (Carlton, Vic.), 24(1), 50-55. https://doi.org/10.1111/nep.13173
Otobe Y, et al. Mild Cognitive Impairment in Older Adults With Pre-dialysis Patients With Chronic Kidney Disease: Prevalence and Association With Physical Function. Nephrology (Carlton). 2019;24(1):50-55. PubMed PMID: 28949427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mild cognitive impairment in older adults with pre-dialysis patients with chronic kidney disease: Prevalence and association with physical function. AU - Otobe,Yuhei, AU - Hiraki,Koji, AU - Hotta,Chiharu, AU - Nishizawa,Hajime, AU - Izawa,Kazuhiro P, AU - Taki,Yasuhiro, AU - Imai,Naohiko, AU - Sakurada,Tsutomu, AU - Shibagaki,Yugo, PY - 2017/09/21/accepted PY - 2017/9/28/pubmed PY - 2019/4/10/medline PY - 2017/9/27/entrez KW - gait speed KW - mild cognitive impairment KW - physical function KW - pre-dialysis chronic kidney disease KW - risk factors SP - 50 EP - 55 JF - Nephrology (Carlton, Vic.) JO - Nephrology (Carlton) VL - 24 IS - 1 N2 - AIM: Chronic kidney disease (CKD) is a risk factor for declining cognitive and physical function. However, the prevalence of mild cognitive impairment (MCI) and its relationship with physical function is not clear. Therefore, our aim was to evaluate the prevalence of MCI and the relationship between MCI and physical function among older adults with pre-dialysis CKD. METHODS: We conducted a cross-sectional study of 120 patients, aged ≥65 years (mean age, 77.3 years), with pre-dialysis CKD but without probable dementia (Mini Mental State Examination <24). MCI was evaluated using the Japanese version of the Montreal Cognitive Assessment (MoCA-J). For analysis, patients were classified into two cognitive function groups: normal (MoCA-J ≥ 26) and MCI (MoCA-J < 26). Physical, clinical, and biochemical parameters were compared between the groups. Logistic and linear regression analyses were used to evaluate the specific association between cognitive and physical function. RESULTS: Seventy-five (62.5%) patients belonged to the MCI group. Significant differences between the two groups were identified for gait speed, balance, age, and haemoglobin concentration. After adjustment for covariates, only gait speed was significantly associated with MCI (odds ratio, 0.06; 95% confidence interval, 0.009-0,411). CONCLUSION: The prevalence of MCI among older adults with pre-dialysis CKD was as high as 62.5%. The association between MCI and reduced gait speed supports the possible interaction between physical and cognitive functions and the need for early screening. SN - 1440-1797 UR - https://www.unboundmedicine.com/medline/citation/28949427/Mild_cognitive_impairment_in_older_adults_with_pre_dialysis_patients_with_chronic_kidney_disease:_Prevalence_and_association_with_physical_function_ L2 - https://doi.org/10.1111/nep.13173 DB - PRIME DP - Unbound Medicine ER -