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The Effect of Age and Initial Central Retinal Thickness on Earlier Need of Repeat Ozurdex Treatment for Macular Edema Due to Retinal Vein Occlusion: A Retrospective Case Series.
J Ocul Pharmacol Ther. 2017 12; 33(10):763-772.JO

Abstract

PURPOSE

To evaluate the effects of dexamethasone intravitreal implant (Ozurdex) and identify risk factors for repeated treatment in patients with macula edema due to branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO).

METHODS

Patients followed up for at least 6 months were enrolled from 2013 to 2016. Dexamethasone intravitreal implant was given as the baseline treatment. For evaluation of dexamethasone intravitreal implant effects and complications, the demographics, medical history, best-corrected visual acuity (BCVA), intraocular pressure, and central retinal thickness (CRT) were recorded. Multivariate Cox proportional hazard model and logistic regression were used to identify factors for repeated treatment.

RESULTS

Twenty-three BRVO and 11 CRVO patients were enrolled. There were 15 males and 19 females. Fifteen (44.12%) patients needed only one dexamethasone intravitreal implant. The peak CRT and BCVA significantly improved. Comparing single-injection with multiple-injection group, age and initial CRT more than 400 μm were significantly higher in the multiple-injection group. From multivariate logistic regression and Cox proportional hazards analysis, patients with age older than 55 years and initial CRT more than 400 μm had higher risk for multiple injections.

CONCLUSIONS

Patients receiving as-needed schedule of dexamethasone intravitreal implant had significant peak CRT and BCVA improvement. Age older than 55 years and initial CRT more than 400 μm were significant risk factors associated with repeated dexamethasone intravitreal implant treatment.

Authors+Show Affiliations

1 Department of Ophthalmology, China Medical University Hospital, China Medical University , Taichung, Taiwan . 2 School of Medicine, College of Medicine, China Medical University , Taichung, Taiwan .3 An-Shin Dialysis Center , NephroCare Ltd., Fresenius Medical Care, Taichung, Taiwan .1 Department of Ophthalmology, China Medical University Hospital, China Medical University , Taichung, Taiwan .1 Department of Ophthalmology, China Medical University Hospital, China Medical University , Taichung, Taiwan . 4 Graduate Institute of Clinical Medical Science, China Medical University , Taichung, Taiwan .1 Department of Ophthalmology, China Medical University Hospital, China Medical University , Taichung, Taiwan . 2 School of Medicine, College of Medicine, China Medical University , Taichung, Taiwan . 5 School of Chinese Medicine, College of Chinese Medicine, China Medical University , Taichung, Taiwan .1 Department of Ophthalmology, China Medical University Hospital, China Medical University , Taichung, Taiwan . 2 School of Medicine, College of Medicine, China Medical University , Taichung, Taiwan . 5 School of Chinese Medicine, College of Chinese Medicine, China Medical University , Taichung, Taiwan .1 Department of Ophthalmology, China Medical University Hospital, China Medical University , Taichung, Taiwan .1 Department of Ophthalmology, China Medical University Hospital, China Medical University , Taichung, Taiwan .1 Department of Ophthalmology, China Medical University Hospital, China Medical University , Taichung, Taiwan . 2 School of Medicine, College of Medicine, China Medical University , Taichung, Taiwan .

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28949790

Citation

Lin, Chun-Ju, et al. "The Effect of Age and Initial Central Retinal Thickness On Earlier Need of Repeat Ozurdex Treatment for Macular Edema Due to Retinal Vein Occlusion: a Retrospective Case Series." Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics, vol. 33, no. 10, 2017, pp. 763-772.
Lin CJ, Chen HS, Su CW, et al. The Effect of Age and Initial Central Retinal Thickness on Earlier Need of Repeat Ozurdex Treatment for Macular Edema Due to Retinal Vein Occlusion: A Retrospective Case Series. J Ocul Pharmacol Ther. 2017;33(10):763-772.
Lin, C. J., Chen, H. S., Su, C. W., Tien, P. T., Lin, J. M., Chen, W. L., Kuo, C. Y., Lai, C. T., & Tsai, Y. Y. (2017). The Effect of Age and Initial Central Retinal Thickness on Earlier Need of Repeat Ozurdex Treatment for Macular Edema Due to Retinal Vein Occlusion: A Retrospective Case Series. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics, 33(10), 763-772. https://doi.org/10.1089/jop.2017.0070
Lin CJ, et al. The Effect of Age and Initial Central Retinal Thickness On Earlier Need of Repeat Ozurdex Treatment for Macular Edema Due to Retinal Vein Occlusion: a Retrospective Case Series. J Ocul Pharmacol Ther. 2017;33(10):763-772. PubMed PMID: 28949790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effect of Age and Initial Central Retinal Thickness on Earlier Need of Repeat Ozurdex Treatment for Macular Edema Due to Retinal Vein Occlusion: A Retrospective Case Series. AU - Lin,Chun-Ju, AU - Chen,Huan-Sheng, AU - Su,Cheng-Wen, AU - Tien,Peng-Tai, AU - Lin,Jane-Ming, AU - Chen,Wen-Lu, AU - Kuo,Chung-Yuan, AU - Lai,Chun-Ting, AU - Tsai,Yi-Yu, Y1 - 2017/09/26/ PY - 2017/9/28/pubmed PY - 2018/3/20/medline PY - 2017/9/27/entrez KW - age KW - branch retinal vein occlusion KW - central retinal thickness KW - central retinal vein occlusion KW - dexamethasone intravitreal implant KW - macular edema SP - 763 EP - 772 JF - Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics JO - J Ocul Pharmacol Ther VL - 33 IS - 10 N2 - PURPOSE: To evaluate the effects of dexamethasone intravitreal implant (Ozurdex) and identify risk factors for repeated treatment in patients with macula edema due to branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO). METHODS: Patients followed up for at least 6 months were enrolled from 2013 to 2016. Dexamethasone intravitreal implant was given as the baseline treatment. For evaluation of dexamethasone intravitreal implant effects and complications, the demographics, medical history, best-corrected visual acuity (BCVA), intraocular pressure, and central retinal thickness (CRT) were recorded. Multivariate Cox proportional hazard model and logistic regression were used to identify factors for repeated treatment. RESULTS: Twenty-three BRVO and 11 CRVO patients were enrolled. There were 15 males and 19 females. Fifteen (44.12%) patients needed only one dexamethasone intravitreal implant. The peak CRT and BCVA significantly improved. Comparing single-injection with multiple-injection group, age and initial CRT more than 400 μm were significantly higher in the multiple-injection group. From multivariate logistic regression and Cox proportional hazards analysis, patients with age older than 55 years and initial CRT more than 400 μm had higher risk for multiple injections. CONCLUSIONS: Patients receiving as-needed schedule of dexamethasone intravitreal implant had significant peak CRT and BCVA improvement. Age older than 55 years and initial CRT more than 400 μm were significant risk factors associated with repeated dexamethasone intravitreal implant treatment. SN - 1557-7732 UR - https://www.unboundmedicine.com/medline/citation/28949790/The_Effect_of_Age_and_Initial_Central_Retinal_Thickness_on_Earlier_Need_of_Repeat_Ozurdex_Treatment_for_Macular_Edema_Due_to_Retinal_Vein_Occlusion:_A_Retrospective_Case_Series_ L2 - https://www.liebertpub.com/doi/10.1089/jop.2017.0070?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -