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# New comprehensive mathematical model for HPMC-MCC based matrices to design oral controlled release systems.Eur J Pharm Biopharm. 2017 Dec; 121:61-72.EJ

Abstract

A comprehensive model with all effective phenomena in drug release such as diffusion, swelling and erosion was considered. In this work, a mathematical model was developed to describe drug release from controlled release HPMC matrices as a favorable system in pharmaceutical industries. As a novel study, the impact of the MCC presence as a filler in tablet preparation process was considered in the mathematical model. In addition, we found that the volume expansion of these polymeric matrices did not follow the ideal mixing rule and we derived an equation for estimating the volume of hydrated matrix. Furthermore, some equations were derived to estimate the parameters of model (Kerosion, Deq) as well as the change in matrix volume based on the amount of polymer and filler in formulation. This investigation gave deeper insight into underlying drug release mechanisms. According to the results, Kerosion increases linearly and Deq increases exponentially with the increase in the amount of MCC in formulation. Application of this comprehensive mathematical model enables us to predict the behavior of HPMC-MCC based matrices. Furthermore, this model is able to represent the formulation for the desired drug release profile which is useful to design new controlled release matrix as well as improving the system geometry and dimensions of tablets. The presented model was validated by two independent tests: (a) predicting the behavior of matrix with certain MCC/HPMC ratio upon exposure to the release medium; (b) designing formulation of Bupropion hydrochloride extended release tablet.

### Authors+Show Affiliations

Department of Life Science Engineering, Faculty of New Science and Technology, University of Tehran, Iran. Electronic address: mansourp@ut.ac.ir.School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.R&D Department, Omid Behboud Pharmaceutical Company, Tehran, Iran.School of Medicine, Tehran University of Medical Science, Iran.School of Pharmacy, Tehran University of Medical Science, Iran.

Journal Article

eng

28951063

### Citation

Saeidipour, Fatemeh, et al. "New Comprehensive Mathematical Model for HPMC-MCC Based Matrices to Design Oral Controlled Release Systems." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 121, 2017, pp. 61-72.
Saeidipour F, Mansourpour Z, Mortazavian E, et al. New comprehensive mathematical model for HPMC-MCC based matrices to design oral controlled release systems. Eur J Pharm Biopharm. 2017;121:61-72.
Saeidipour, F., Mansourpour, Z., Mortazavian, E., Rafiee-Tehrani, N., & Rafiee-Tehrani, M. (2017). New comprehensive mathematical model for HPMC-MCC based matrices to design oral controlled release systems. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 121, 61-72. https://doi.org/10.1016/j.ejpb.2017.09.007
Saeidipour F, et al. New Comprehensive Mathematical Model for HPMC-MCC Based Matrices to Design Oral Controlled Release Systems. Eur J Pharm Biopharm. 2017;121:61-72. PubMed PMID: 28951063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New comprehensive mathematical model for HPMC-MCC based matrices to design oral controlled release systems. AU - Saeidipour,Fatemeh, AU - Mansourpour,Zahra, AU - Mortazavian,Elaheh, AU - Rafiee-Tehrani,Niyousha, AU - Rafiee-Tehrani,Morteza, Y1 - 2017/09/22/ PY - 2017/05/09/received PY - 2017/08/14/revised PY - 2017/09/11/accepted PY - 2017/9/28/pubmed PY - 2018/6/7/medline PY - 2017/9/28/entrez KW - Controlled release systems KW - Drug delivery KW - Extended release tablet KW - HPMC matrix KW - Mathematical modeling SP - 61 EP - 72 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 121 N2 - A comprehensive model with all effective phenomena in drug release such as diffusion, swelling and erosion was considered. In this work, a mathematical model was developed to describe drug release from controlled release HPMC matrices as a favorable system in pharmaceutical industries. As a novel study, the impact of the MCC presence as a filler in tablet preparation process was considered in the mathematical model. In addition, we found that the volume expansion of these polymeric matrices did not follow the ideal mixing rule and we derived an equation for estimating the volume of hydrated matrix. Furthermore, some equations were derived to estimate the parameters of model (Kerosion, Deq) as well as the change in matrix volume based on the amount of polymer and filler in formulation. This investigation gave deeper insight into underlying drug release mechanisms. According to the results, Kerosion increases linearly and Deq increases exponentially with the increase in the amount of MCC in formulation. Application of this comprehensive mathematical model enables us to predict the behavior of HPMC-MCC based matrices. Furthermore, this model is able to represent the formulation for the desired drug release profile which is useful to design new controlled release matrix as well as improving the system geometry and dimensions of tablets. The presented model was validated by two independent tests: (a) predicting the behavior of matrix with certain MCC/HPMC ratio upon exposure to the release medium; (b) designing formulation of Bupropion hydrochloride extended release tablet. SN - 1873-3441 UR - https://www.unboundmedicine.com/medline/citation/28951063/New_comprehensive_mathematical_model_for_HPMC_MCC_based_matrices_to_design_oral_controlled_release_systems_ DB - PRIME DP - Unbound Medicine ER -
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