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Clinical response to radioactive iodine therapy for prophylactic central neck dissection is not superior to total thyroidectomy alone in cN0 patients with papillary thyroid cancer.
Nucl Med Commun. 2017 Dec; 38(12):1036-1040.NM

Abstract

OBJECTIVE

Prophylactic central neck dissection (pCND) is controversial in papillary thyroid carcinoma (PTC) without clinical positive lymph nodes. The aim of this study was to investigate the effect of radioactive iodine (RAI) therapy on the clinical outcome in clinically node-negative (cN0) PTC patients treated with total thyroidectomy (TT) alone or in combination with pCND.

PATIENTS AND METHODS

One-hundred and sixty-seven cN0 PTC patients who underwent TT alone (TT) or in combination with pCND (TT+pCND) in our hospital from January 2014 to August 2015 were evaluated retrospectively. Adjuvant RAI therapy was recommended depending on tumor diameter, multifocality, extrathyroidal extension, the presence of positive lymph nodes, and adverse histopathologic features. Serological and imaging data were collected with a mean follow-up of 29.9±5.2 months after RAI administration. Suppressed and stimulated thyroglobulin, thyroglobulin antibody, diagnostic whole-body scintigraphy, and other imaging examinations were used to assess clinical outcome, which was defined as excellent response, indeterminate response, biochemical incomplete response, and structural incomplete response.

RESULTS

TT was performed in 62 (37.1%) and TT+pCND in 105 (62.9%). The rate of permanent hypoparathyroidism was significantly higher in TT+pCND than that of TT alone (14.2 vs. 3.2%, P=0.0316). Because of the detection of central neck lymph node metastases by pCND, 42 (40%) patients developed higher recurrence risk stratification (from low to intermediate) and 12 (11.4%) patients were upstaged in TNM staging. RAI therapy was performed for 46 (74.2%) patients in the TT group and 87 (82.9%) in the TT+pCND group. The mean dose for patients receiving RAI in the TT+pCND group was significantly higher than that in the TT group (113.9±23.1 vs. 93.9±18.1, P<0.0001). No significant difference in response to RAI therapy was found between the TT group and the TT+pCND group (P=0.9474).

CONCLUSION

Although the addition of pCND to TT, with a concomitant higher frequency of permanent hypoparathyroidism, upstages 40% of patients, thereby changing the dose of RAI therapy, the clinical response to RAI therapy for TT+pCND is not superior to TT alone in cN0 PTC patients.

Authors+Show Affiliations

Departments of aNuclear Medicine bThyroid Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28953211

Citation

Lin, Bai, et al. "Clinical Response to Radioactive Iodine Therapy for Prophylactic Central Neck Dissection Is Not Superior to Total Thyroidectomy Alone in cN0 Patients With Papillary Thyroid Cancer." Nuclear Medicine Communications, vol. 38, no. 12, 2017, pp. 1036-1040.
Lin B, Qiang W, Wenqi Z, et al. Clinical response to radioactive iodine therapy for prophylactic central neck dissection is not superior to total thyroidectomy alone in cN0 patients with papillary thyroid cancer. Nucl Med Commun. 2017;38(12):1036-1040.
Lin, B., Qiang, W., Wenqi, Z., Tianyu, Y., Lina, Z., & Bin, J. (2017). Clinical response to radioactive iodine therapy for prophylactic central neck dissection is not superior to total thyroidectomy alone in cN0 patients with papillary thyroid cancer. Nuclear Medicine Communications, 38(12), 1036-1040. https://doi.org/10.1097/MNM.0000000000000756
Lin B, et al. Clinical Response to Radioactive Iodine Therapy for Prophylactic Central Neck Dissection Is Not Superior to Total Thyroidectomy Alone in cN0 Patients With Papillary Thyroid Cancer. Nucl Med Commun. 2017;38(12):1036-1040. PubMed PMID: 28953211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical response to radioactive iodine therapy for prophylactic central neck dissection is not superior to total thyroidectomy alone in cN0 patients with papillary thyroid cancer. AU - Lin,Bai, AU - Qiang,Wen, AU - Wenqi,Zhang, AU - Tianyu,Yu, AU - Lina,Zhao, AU - Bin,Ji, PY - 2017/9/28/pubmed PY - 2018/7/20/medline PY - 2017/9/28/entrez SP - 1036 EP - 1040 JF - Nuclear medicine communications JO - Nucl Med Commun VL - 38 IS - 12 N2 - OBJECTIVE: Prophylactic central neck dissection (pCND) is controversial in papillary thyroid carcinoma (PTC) without clinical positive lymph nodes. The aim of this study was to investigate the effect of radioactive iodine (RAI) therapy on the clinical outcome in clinically node-negative (cN0) PTC patients treated with total thyroidectomy (TT) alone or in combination with pCND. PATIENTS AND METHODS: One-hundred and sixty-seven cN0 PTC patients who underwent TT alone (TT) or in combination with pCND (TT+pCND) in our hospital from January 2014 to August 2015 were evaluated retrospectively. Adjuvant RAI therapy was recommended depending on tumor diameter, multifocality, extrathyroidal extension, the presence of positive lymph nodes, and adverse histopathologic features. Serological and imaging data were collected with a mean follow-up of 29.9±5.2 months after RAI administration. Suppressed and stimulated thyroglobulin, thyroglobulin antibody, diagnostic whole-body scintigraphy, and other imaging examinations were used to assess clinical outcome, which was defined as excellent response, indeterminate response, biochemical incomplete response, and structural incomplete response. RESULTS: TT was performed in 62 (37.1%) and TT+pCND in 105 (62.9%). The rate of permanent hypoparathyroidism was significantly higher in TT+pCND than that of TT alone (14.2 vs. 3.2%, P=0.0316). Because of the detection of central neck lymph node metastases by pCND, 42 (40%) patients developed higher recurrence risk stratification (from low to intermediate) and 12 (11.4%) patients were upstaged in TNM staging. RAI therapy was performed for 46 (74.2%) patients in the TT group and 87 (82.9%) in the TT+pCND group. The mean dose for patients receiving RAI in the TT+pCND group was significantly higher than that in the TT group (113.9±23.1 vs. 93.9±18.1, P<0.0001). No significant difference in response to RAI therapy was found between the TT group and the TT+pCND group (P=0.9474). CONCLUSION: Although the addition of pCND to TT, with a concomitant higher frequency of permanent hypoparathyroidism, upstages 40% of patients, thereby changing the dose of RAI therapy, the clinical response to RAI therapy for TT+pCND is not superior to TT alone in cN0 PTC patients. SN - 1473-5628 UR - https://www.unboundmedicine.com/medline/citation/28953211/Clinical_response_to_radioactive_iodine_therapy_for_prophylactic_central_neck_dissection_is_not_superior_to_total_thyroidectomy_alone_in_cN0_patients_with_papillary_thyroid_cancer_ L2 - http://dx.doi.org/10.1097/MNM.0000000000000756 DB - PRIME DP - Unbound Medicine ER -