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Simultaneous and Sequential MS/MS Scan Combinations and Permutations in a Linear Quadrupole Ion Trap.
Anal Chem. 2017 10 17; 89(20):11053-11060.AC

Abstract

Methods of performing precursor ion scans as well as neutral loss scans in a single linear quadrupole ion trap have recently been described. In this paper we report methodology for performing permutations of MS/MS scan modes, that is, ordered combinations of precursor, product, and neutral loss scans following a single ion injection event. Only particular permutations are allowed; the sequences demonstrated here are (1) multiple precursor ion scans, (2) precursor ion scans followed by a single neutral loss scan, (3) precursor ion scans followed by product ion scans, and (4) segmented neutral loss scans. (5) The common product ion scan can be performed earlier in these sequences, under certain conditions. Simultaneous scans can also be performed. These include multiple precursor ion scans, precursor ion scans with an accompanying neutral loss scan, and multiple neutral loss scans. We argue that the new capability to perform complex simultaneous and sequential MSn operations on single ion populations represents a significant step in increasing the selectivity of mass spectrometry.

Authors+Show Affiliations

Department of Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.Department of Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.Department of Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

28953354

Citation

Snyder, Dalton T., et al. "Simultaneous and Sequential MS/MS Scan Combinations and Permutations in a Linear Quadrupole Ion Trap." Analytical Chemistry, vol. 89, no. 20, 2017, pp. 11053-11060.
Snyder DT, Szalwinski LJ, Cooks RG. Simultaneous and Sequential MS/MS Scan Combinations and Permutations in a Linear Quadrupole Ion Trap. Anal Chem. 2017;89(20):11053-11060.
Snyder, D. T., Szalwinski, L. J., & Cooks, R. G. (2017). Simultaneous and Sequential MS/MS Scan Combinations and Permutations in a Linear Quadrupole Ion Trap. Analytical Chemistry, 89(20), 11053-11060. https://doi.org/10.1021/acs.analchem.7b03064
Snyder DT, Szalwinski LJ, Cooks RG. Simultaneous and Sequential MS/MS Scan Combinations and Permutations in a Linear Quadrupole Ion Trap. Anal Chem. 2017 10 17;89(20):11053-11060. PubMed PMID: 28953354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous and Sequential MS/MS Scan Combinations and Permutations in a Linear Quadrupole Ion Trap. AU - Snyder,Dalton T, AU - Szalwinski,Lucas J, AU - Cooks,R Graham, Y1 - 2017/10/06/ PY - 2017/9/28/pubmed PY - 2017/9/28/medline PY - 2017/9/28/entrez SP - 11053 EP - 11060 JF - Analytical chemistry JO - Anal. Chem. VL - 89 IS - 20 N2 - Methods of performing precursor ion scans as well as neutral loss scans in a single linear quadrupole ion trap have recently been described. In this paper we report methodology for performing permutations of MS/MS scan modes, that is, ordered combinations of precursor, product, and neutral loss scans following a single ion injection event. Only particular permutations are allowed; the sequences demonstrated here are (1) multiple precursor ion scans, (2) precursor ion scans followed by a single neutral loss scan, (3) precursor ion scans followed by product ion scans, and (4) segmented neutral loss scans. (5) The common product ion scan can be performed earlier in these sequences, under certain conditions. Simultaneous scans can also be performed. These include multiple precursor ion scans, precursor ion scans with an accompanying neutral loss scan, and multiple neutral loss scans. We argue that the new capability to perform complex simultaneous and sequential MSn operations on single ion populations represents a significant step in increasing the selectivity of mass spectrometry. SN - 1520-6882 UR - https://www.unboundmedicine.com/medline/citation/28953354/Simultaneous_and_Sequential_MS/MS_Scan_Combinations_and_Permutations_in_a_Linear_Quadrupole_Ion_Trap_ L2 - https://dx.doi.org/10.1021/acs.analchem.7b03064 DB - PRIME DP - Unbound Medicine ER -
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