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Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals.
Nutrients 2017; 9(10)N

Abstract

Non-alcoholic fatty liver disease (NAFLD) incorporates an extensive spectrum of histologic liver abnormalities, varying from simple triglyceride accumulation in hepatocytes non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), and it is the most frequent chronic liver disease in the industrialized world. Beyond liver related complications such as cirrhosis and hepatocellular carcinoma, NAFLD is also an emerging risk factor for type 2 diabetes and cardiovascular disease. Currently, lifestyle intervention including strategies to reduce body weight and to increase regular physical activity represents the mainstay of NAFLD management. Total caloric intake plays a very important role in both the development and the treatment of NAFLD; however, apart from the caloric restriction alone, modifying the quality of the diet and modulating either the macro- or micronutrient composition can also markedly affect the clinical evolution of NAFLD, offering a more realistic and feasible treatment alternative. The aim of the present review is to summarize currently available evidence from randomized controlled trials on the effects of different nutrients including carbohydrates, lipids, protein and other dietary components, in isocaloric conditions, on NAFLD in people at high cardiometabolic risk. We also describe the plausible mechanisms by which different dietary components could modulate liver fat content.

Authors+Show Affiliations

Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. gdp0206@libero.it.Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. c.vetrani@libero.it.Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. lombardi.gian@gmail.com.Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. lutgarda.bozzetto@unina.it.Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. annuzzi@unina.it.Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. rivelles@unina.it.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28954437

Citation

Della Pepa, Giuseppe, et al. "Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals." Nutrients, vol. 9, no. 10, 2017.
Della Pepa G, Vetrani C, Lombardi G, et al. Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals. Nutrients. 2017;9(10).
Della Pepa, G., Vetrani, C., Lombardi, G., Bozzetto, L., Annuzzi, G., & Rivellese, A. A. (2017). Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals. Nutrients, 9(10), doi:10.3390/nu9101065.
Della Pepa G, et al. Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals. Nutrients. 2017 Sep 26;9(10) PubMed PMID: 28954437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals. AU - Della Pepa,Giuseppe, AU - Vetrani,Claudia, AU - Lombardi,Gianluca, AU - Bozzetto,Lutgarda, AU - Annuzzi,Giovanni, AU - Rivellese,Angela Albarosa, Y1 - 2017/09/26/ PY - 2017/08/03/received PY - 2017/08/28/revised PY - 2017/09/21/accepted PY - 2017/9/29/entrez PY - 2017/9/29/pubmed PY - 2018/6/5/medline KW - NAFLD KW - NASH KW - carbohydrates KW - isocaloric dietary changes KW - monounsaturated fatty acids KW - polyphenols KW - polyunsaturated fatty acids KW - vitamins JF - Nutrients JO - Nutrients VL - 9 IS - 10 N2 - Non-alcoholic fatty liver disease (NAFLD) incorporates an extensive spectrum of histologic liver abnormalities, varying from simple triglyceride accumulation in hepatocytes non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), and it is the most frequent chronic liver disease in the industrialized world. Beyond liver related complications such as cirrhosis and hepatocellular carcinoma, NAFLD is also an emerging risk factor for type 2 diabetes and cardiovascular disease. Currently, lifestyle intervention including strategies to reduce body weight and to increase regular physical activity represents the mainstay of NAFLD management. Total caloric intake plays a very important role in both the development and the treatment of NAFLD; however, apart from the caloric restriction alone, modifying the quality of the diet and modulating either the macro- or micronutrient composition can also markedly affect the clinical evolution of NAFLD, offering a more realistic and feasible treatment alternative. The aim of the present review is to summarize currently available evidence from randomized controlled trials on the effects of different nutrients including carbohydrates, lipids, protein and other dietary components, in isocaloric conditions, on NAFLD in people at high cardiometabolic risk. We also describe the plausible mechanisms by which different dietary components could modulate liver fat content. SN - 2072-6643 UR - http://www.unboundmedicine.com/medline/citation/28954437/Isocaloric_Dietary_Changes_and_Non_Alcoholic_Fatty_Liver_Disease_in_High_Cardiometabolic_Risk_Individuals_ L2 - http://www.mdpi.com/resolver?pii=nu9101065 DB - PRIME DP - Unbound Medicine ER -