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Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals.

Abstract

Non-alcoholic fatty liver disease (NAFLD) incorporates an extensive spectrum of histologic liver abnormalities, varying from simple triglyceride accumulation in hepatocytes non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), and it is the most frequent chronic liver disease in the industrialized world. Beyond liver related complications such as cirrhosis and hepatocellular carcinoma, NAFLD is also an emerging risk factor for type 2 diabetes and cardiovascular disease. Currently, lifestyle intervention including strategies to reduce body weight and to increase regular physical activity represents the mainstay of NAFLD management. Total caloric intake plays a very important role in both the development and the treatment of NAFLD; however, apart from the caloric restriction alone, modifying the quality of the diet and modulating either the macro- or micronutrient composition can also markedly affect the clinical evolution of NAFLD, offering a more realistic and feasible treatment alternative. The aim of the present review is to summarize currently available evidence from randomized controlled trials on the effects of different nutrients including carbohydrates, lipids, protein and other dietary components, in isocaloric conditions, on NAFLD in people at high cardiometabolic risk. We also describe the plausible mechanisms by which different dietary components could modulate liver fat content.

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  • Authors+Show Affiliations

    ,

    Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. gdp0206@libero.it.

    ,

    Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. c.vetrani@libero.it.

    ,

    Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. lombardi.gian@gmail.com.

    ,

    Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. lutgarda.bozzetto@unina.it.

    ,

    Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. annuzzi@unina.it.

    Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. rivelles@unina.it.

    Source

    Nutrients 9:10 2017 Sep 26 pg

    MeSH

    Cardiovascular Diseases
    Diabetes Mellitus, Type 2
    Energy Intake
    Feeding Behavior
    Habits
    Healthy Diet
    Humans
    Lipid Metabolism
    Liver
    Non-alcoholic Fatty Liver Disease
    Nutritive Value
    Obesity
    Prognosis
    Protective Factors
    Recommended Dietary Allowances
    Risk Assessment
    Risk Factors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    28954437

    Citation

    Della Pepa, Giuseppe, et al. "Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals." Nutrients, vol. 9, no. 10, 2017.
    Della Pepa G, Vetrani C, Lombardi G, et al. Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals. Nutrients. 2017;9(10).
    Della Pepa, G., Vetrani, C., Lombardi, G., Bozzetto, L., Annuzzi, G., & Rivellese, A. A. (2017). Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals. Nutrients, 9(10), doi:10.3390/nu9101065.
    Della Pepa G, et al. Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals. Nutrients. 2017 Sep 26;9(10) PubMed PMID: 28954437.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals. AU - Della Pepa,Giuseppe, AU - Vetrani,Claudia, AU - Lombardi,Gianluca, AU - Bozzetto,Lutgarda, AU - Annuzzi,Giovanni, AU - Rivellese,Angela Albarosa, Y1 - 2017/09/26/ PY - 2017/08/03/received PY - 2017/08/28/revised PY - 2017/09/21/accepted PY - 2017/9/29/entrez PY - 2017/9/29/pubmed PY - 2018/6/5/medline KW - NAFLD KW - NASH KW - carbohydrates KW - isocaloric dietary changes KW - monounsaturated fatty acids KW - polyphenols KW - polyunsaturated fatty acids KW - vitamins JF - Nutrients JO - Nutrients VL - 9 IS - 10 N2 - Non-alcoholic fatty liver disease (NAFLD) incorporates an extensive spectrum of histologic liver abnormalities, varying from simple triglyceride accumulation in hepatocytes non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), and it is the most frequent chronic liver disease in the industrialized world. Beyond liver related complications such as cirrhosis and hepatocellular carcinoma, NAFLD is also an emerging risk factor for type 2 diabetes and cardiovascular disease. Currently, lifestyle intervention including strategies to reduce body weight and to increase regular physical activity represents the mainstay of NAFLD management. Total caloric intake plays a very important role in both the development and the treatment of NAFLD; however, apart from the caloric restriction alone, modifying the quality of the diet and modulating either the macro- or micronutrient composition can also markedly affect the clinical evolution of NAFLD, offering a more realistic and feasible treatment alternative. The aim of the present review is to summarize currently available evidence from randomized controlled trials on the effects of different nutrients including carbohydrates, lipids, protein and other dietary components, in isocaloric conditions, on NAFLD in people at high cardiometabolic risk. We also describe the plausible mechanisms by which different dietary components could modulate liver fat content. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/28954437/Isocaloric_Dietary_Changes_and_Non_Alcoholic_Fatty_Liver_Disease_in_High_Cardiometabolic_Risk_Individuals_ L2 - http://www.mdpi.com/resolver?pii=nu9101065 DB - PRIME DP - Unbound Medicine ER -